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Depo-Testosterone (Generic Testosterone Injection)

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During or just after the injection, testosterone undecanoate injection (Aveed) may induce severe respiratory issues and allergic reactions. A physician or nurse should administer the injection at a medical facility where these issues or reactions can be managed. Following your injection, you must stay in the medical facility for at least 30 minutes. If you experience any of the following symptoms during or after receiving your injection, let your doctor or nurse know right away: tightening of the throat, trouble breathing, trouble swallowing, shortness of breath, cough or urge to cough, chest pain, dizziness, fainting, sweating, rash, hives, or itching.

The usage of testosterone undecanoate injectable (Aveed) has been restricted, and a campaign has been launched to educate consumers about the medication’s elevated risk of allergic reactions and respiratory issues. The programme also ensures that all patients receiving the medicine are aware of its risks and advantages and receive it in a setting where they can be watched closely for negative side effects.

The testosterone enanthate injectable (Xyosted) and other testosterone-containing drugs may raise blood pressure, which raises the possibility of a potentially fatal heart attack or stroke. If you have high blood pressure, cardiac disease, a heart attack, or a stroke, let your doctor know. If you take any medications for your blood pressure, discomfort, or cold symptoms, let your doctor and chemist know. Call your doctor right away if you have any of the following symptoms: Chest discomfort, shortness of breath, jaw, back, or arm pain; slurred speech; shakiness; feeling dizzy or faint; or weakness or numbness in an arm or leg.

Keep all of your appointments with your physician and the lab. Regular blood pressure checks are advised.

When you start therapy with testosterone undecanoate injection or testosterone enanthate injection, your doctor or chemist will provide you the medication guide from the manufacturer (Xyosted). If you have any questions, carefully read the information and ask your doctor or chemist. The Medication Guide is also available on the manufacturer’s website or the Food and Drug Administration (FDA) website (

Why is this medication prescribed?

The symptoms of low testosterone in hypogonadically affected males are treated with testosterone injections such as testosterone cypionate (Depo-Testosterone), testosterone enanthate (Xyosted, a generic version), testosterone undecanoate (Aveed), and testosterone pellet (Testopel) (a condition in which the body does not produce enough natural testosterone). Only men with low testosterone levels brought on by specific illnesses, such as problems with the testicles, pituitary gland (a tiny gland in the brain), or hypothalamus (a portion of the brain), which results in hypogonadism, are treated with testosterone. Before you start using testosterone injections, your doctor will request specific blood tests to examine your testosterone levels and see if they are low. Males with delayed puberty can also benefit from the usage of testosterone enanthate (generic available) and testosterone pellets (Testopel). Injections of testosterone enanthate, which is available generically, may be utilised by certain women whose mammary cancer has progressed to other body areas. When men experience low testosterone as a result of ageing (also known as “age-related hypogonadism”), testosterone should not be used to address the symptoms of low testosterone. The class of drugs known as androgenic hormones includes testosterone. The male sexual organs and other typical male traits grow, develop, and function as a result of the hormone testosterone, which is created by the body. The way a testosterone injection works is by replacing the testosterone that the body ordinarily produces naturally with synthetic testosterone. Testosterone prevents the release of oestrogen when used to treat breast cancer.

How should this medicine be used?

A doctor or nurse in an office setting or clinic can administer testosterone cypionate, testosterone enanthate (which is generically accessible), and testosterone undecanoate injection as a solution (liquid) to be injected into a muscle or as a pellet to be injected beneath the skin. You or a carer must inject testosterone enanthate injection (Xyosted) subcutaneously (under the skin) once every week. It comes as a solution (liquid).

Injections of testosterone may help you manage your symptoms but won’t make your disease go away. Depending on the level of testosterone in your blood during therapy and how you respond to the drug, your doctor may change the dosage of your testosterone.

Before injecting your testosterone enanthate (Xyosted) solution, always check it out. It ought to be transparent or light yellow in hue and free of any discernible particles. If it is hazy, has visible particles, or has passed its expiration date on the package, do not use it.

Your navel and the region 2 inches around it are the only parts of your abdomen (stomach) where you cannot inject testosterone enanthate (Xyosted). Never administer an injection to skin that is irritated, bruised, red, or hard, or that has scars, tattoos, or stretch marks.

You will be shown how to administer testosterone enanthate injection by your doctor (Xyosted). Make sure you comprehend these instructions, and if you have any issues, consult your healthcare professional.

For a copy of the manufacturer’s information for the patient, ask your chemist or doctor.

Other uses for this medicine

Ask your doctor or chemist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving testosterone injection,

  • If you have an allergy to testosterone, any other drugs, or any of the components in testosterone injection products, let your doctor and pharmacist know right once. Get a list of the ingredients from your chemist.
  • Inform your doctor and chemist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products that you are now taking or intend to use. Mention the drugs listed in the IMPORTANT WARNING section as well as any of the following: oral steroids like dexamethasone, methylprednisolone (Medrol), and prednisone, as well as anticoagulants (blood thinners) like warfarin (Coumadin, Jantoven), insulin (Apidra, Humalog, Humulin, and others), medications for diabetes, and anticoagulants (blood thinners) like warfarin ( (Rayos). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • If you are a man, let your doctor know whether you have prostate cancer or if you have breast cancer. Moreover, let your doctor know if you have renal, liver, or cardiac issues. Your doctor might advise against getting a testosterone injection.
  • Inform your doctor if you have or have ever had sleep apnea, benign prostatic hyperplasia (BPH), an enlarged prostate, elevated calcium levels in the blood, cancer, diabetes, depression or any mental condition, or lung disease.
  • It’s important to be aware that some testosterone products shouldn’t be used on women (Aveed, Xyosted). In any other case, women who are breastfeeding or who may become pregnant shouldn’t use this drug. The baby could suffer from testosterone’s side effects.
  • You should be aware that individuals who use testosterone at larger levels, in conjunction with other male sex hormone products, or in ways other than those prescribed by a doctor have reported experiencing serious negative effects. Heart attack, heart failure, or other heart issues; stroke and mini-stroke; liver disease; seizures; or changes in mental health like depression, mania (frenzied, abnormally excited mood), aggressive or unfriendly behaviour, hallucinations (seeing things or hearing voices that are not there), or delusions are some of these side effects (having strange thoughts or beliefs that have no basis in reality). If they abruptly stop using testosterone, people who use higher doses of the hormone than are advised by a doctor may also experience withdrawal symptoms like depression, extreme fatigue, craving, irritability, restlessness, loss of appetite, inability to fall or stay asleep, or a decreased sex drive. Use testosterone injection exactly as your doctor has prescribed.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What side effects can this medication cause?

Side effects from testosterone injection are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Acne
  • Breast pain or enlargement
  • Hoarseness
  • Voice getting deeper
  • Injection site discomfort, redness, bruising, bleeding, or hardness
  • Tiredness
  • Having trouble falling or staying asleep
  • Mood changes
  • Gaining weight
  • Headache
  • Joints hurt
  • Back ache

Some adverse effects may be severe. Call your doctor right away if you have any of the following symptoms or any of the ones detailed in the IMPORTANT CAUTION section:

  • Lower leg discomfort, edoema, warmth, or redness
  • Dizziness or vomiting
  • Edoema of the lower legs, ankles, feet, or hands
  • Breathing issues, especially during sleeping
  • Erections that are excessively frequent or prolonged
  • Blood in the pee, weak urine flow, frequent urination, strong urge to urinate immediately away, and difficulties urinating
  • The skin or eyes becoming yellow
  • The top right portion of my stomach hurts
  • Mood swings including despair, anxiety, or considering suicide (thinking about harming or killing oneself or planning or trying to do so)

Injections of testosterone, particularly those given at high levels, have the potential to reduce the quantity of sperm (male reproductive cells) generated. If you’re a guy who wants to start a family, talk to your doctor about the potential hazards of taking this drug.

Prostate cancer risk may rise as a result of testosterone use. You should discuss the dangers of using this drug with your doctor.

In youngsters who receive testosterone injection, the bones may develop more quickly than usual. This implies that the kids might cease growing earlier than anticipated and might end up being shorter as adults.

Other adverse effects from testosterone injection are possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep testosterone enanthate injection (Xyosted) securely closed in the original container, away from children. Keep it away from light, excessive heat, and moisture at room temperature (not in the bathroom). Avoid freezing or refrigeration.

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your chemist or the garbage/recycling agency in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your appointments with your physician and the lab. To determine how your body is responding to testosterone injections, your doctor may request specific tests.

Inform your doctor and the lab staff that you are receiving testosterone injections prior to any laboratory test.

Do not share your testosterone enanthate injectable with anybody else (Xyosted). A controlled substance is testosterone. Only a limited amount of refills are permitted for prescriptions; if you have any questions, speak with your chemist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Aveed®
  • Delatestryl®
  • Depo-Testosterone®
  • Testopel®
  • Xyosted®
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