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Depo-Provera (Generic Medroxyprogesterone Injection)

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An injection of medroxyprogesterone may cause your bones’ calcium reserves to decline. The quantity of calcium in your bones may decrease the longer you use this drug. Even after you stop using medroxyprogesterone injection, the level of calcium in your bones might not return to normal.

Losing calcium from your bones can result in osteoporosis, a condition in which your bones become brittle and brittle, and it can also raise your chance of breaking a bone at some point in your life, particularly after menopause (change of life).

During adolescence, the amount of calcium in the bones typically rises. A decrease in bone calcium during this key stage of bone strengthening may be extremely dangerous. It is not known whether your risk of getting osteoporosis later in life is greater if you start to use medroxyprogesterone injection while you are a teenager or young adult. Inform your doctor if you or anyone in your family has osteoporosis, have previously had anorexia nervosa (an eating disorder), or consume large amounts of alcohol or smoke frequently. Corticosteroids like dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone), as well as seizure drugs like carbamazepine (Tegretol), phenytoin (Dilantin), or phenobarbital, should be disclosed to your doctor if you use any of these (Luminal, Solfoton).

Unless no other method of birth control is suitable for you or no other drug can effectively treat your condition, you shouldn’t use medroxyprogesterone injection for an extended period of time (for example, more than 2 years). Before you continue using medroxyprogesterone injection, your doctor may perform a test on your bones to make sure they are not getting too thin.

Keep all of your appointments with your physician and the lab. Your health will be closely monitored by your doctor to ensure that osteoporosis does not set in.

Speak to your doctor about the hazards of using medroxyprogesterone injection.

Why is this medication prescribed?

Both subcutaneous (under the skin) and intramuscular (into a muscle) injections of medroxyprogesterone are used to prevent pregnancy. Endometriosis, a disorder in which the tissue that lines the uterus (womb) develops in other places of the body and causes pain, heavy or irregular menstruation [periods], and other symptoms, is similarly treated with medroxyprogesterone subcutaneous injection. The class of drugs known as progestins includes medroxyprogesterone. It prevents ovulation in order to prevent conception (the release of eggs from the ovaries). The lining of the uterus is also thinned by medroxyprogesterone. For all women, this aids in preventing conception, and for those who have endometriosis, it delays the spread of tissue from the uterus to other parts of the body. Although the injection of medroxyprogesterone is a fairly efficient birth control treatment, it does not stop the spread of HIV or other sexually transmitted infections.

How should this medicine be used?

The suspension form of medroxyprogesterone intramuscular injection is administered through injection into the upper arm or buttocks. It is often administered by a healthcare professional in an office or clinic once every three months (13 weeks). Subcutaneous injection of medroxyprogesterone is available as a suspension that is injected directly beneath the skin. It is typically administered once every 12 to 14 weeks in a clinic or doctor’s office by a medical professional.

Only when there is no chance that you could be pregnant should you receive your first subcutaneous or intramuscular injection of medroxyprogesterone. Hence, if you intend to breastfeed your child, you may only administer your first injection during the first five days of a regular period, the first five days following delivery, or the sixth week following delivery, whichever comes first. When you should get your first injection of medroxyprogesterone if you are moving from another kind of birth control, your doctor will let you know.

Other uses for this medicine

Ask your doctor or chemist for more details if you’re interested in using this medication for any other conditions.

What special precautions should I follow?

Before using medroxyprogesterone injection,

  • If you have any other allergies notify your doctor and chemist before using medroxyprogesterone (Depo-Provera, depo-subQ provera 104, Provera, in Prempro, in Premphase).
  • Inform your doctor and chemist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products that you are now taking or intend to use. Mention the drugs in the IMPORTANT WARNING section as well as aminoglutethimide (Cytadren). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your doctor if you or anybody in your family currently has or previously had diabetes or breast cancer. Moreover, let your physician know if you now have or have previously had breast issues, such as lumps, nipple bleeding, an abnormal mammogram (breast x-ray), or fibrocystic breast disease (swollen, painful breasts and/or breast lumps that are not cancerous); unaccounted for vaginal bleeding, irregular or light menstrual cycles, excessive weight gain or fluid retention before your period, blood clots in your legs, lungs, brain, or eyes, stroke or mini-stroke, migraine headaches, seizures, depression, high blood pressure, heart attack, asthma, or heart, liver, or kidney disease are all signs that something is wrong.
  • If you plan to get pregnant, are currently pregnant, or suspect you might be pregnant, let your doctor know right away. Call your doctor right away if you get pregnant while taking medroxyprogesterone injectable. The foetus could be harmed by medroxyprogesterone.
  • Inform your doctor if you are nursing a baby. If your infant is six weeks old when you get your first injection, you are permitted to use medroxyprogesterone injection while you are nursing. Medroxyprogesterone may get into your breast milk in small amounts, but there is no evidence that this is detrimental to the infant. Research on infants who were breastfed while their mothers received medroxyprogesterone injections demonstrated that the drugs had no negative effects on the children.
  • Inform the surgeon or dentist that you are using methoxyprogesterone injection if you are having surgery, including dental surgery.
  • You should be aware that while using medroxyprogesterone injection, your menstrual cycle may probably fluctuate. Your first few periods will usually be erratic, and you might bleed between cycles. Your periods could cease entirely if you keep using this medicine. After stopping the medicine, your menstrual cycle will likely return to normal.

What special dietary instructions should I follow?

While receiving medroxyprogesterone injections, you should consume lots of calcium- and vitamin D-rich foods to help prevent calcium loss from your bones. Your doctor will advise you on the best foods to eat in order to get the recommended daily servings of these nutrients. Moreover, your physician can prescribe or suggest calcium or vitamin D supplements.

What should I do if I forget a dose?

Call your doctor if you fail to show up for a scheduled injection of medroxyprogesterone. If you don’t get your shots on time, you might not be protected from pregnancy. Your doctor will let you know when to get the missed injection if you don’t get it when it’s supposed to. Before giving you the missing shot, your doctor will likely perform a pregnancy test to be sure you are not expecting. Until you receive the missed injection, you should use an alternate birth control technique, such as condoms.

What side effects can this medication cause?

Medroxyprogesterone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • Modifications to menstrual cycles (See SPECIAL PRECAUTIONS)
  • Gaining weight
  • Weakness
  • Tiredness
  • Nervousness
  • Irritability
  • Depression
  • Having trouble falling or staying asleep
  • Hot flash
  • Breast ache, soreness, or swelling
  • Constipation or bloating
  • Leg twitches
  • Joint or back ache
  • Acne
  • Hair loss on the scalp
  • Vaginal edoema, redness, irritability, burning, or itchiness
  • White vaginal spotting
  • Alteration of sexual desire
  • Symptoms of a cold or flu
  • Where the drug was injected, you may have pain, itchiness, lumps, redness, or scars

Some side effects can be serious. The following side effects are uncommon, but if you experience any of them, call your doctor immediately:

  • Sudden breathlessness
  • Crushing or sudden chest discomfort
  • Exhaling blood
  • Terrible headache
  • Nausea
  • Vomiting
  • Unsteadiness or weakness
  • Alterations or eyesight loss
  • Dual perception
  • Enlarged eyes
  • Speaking is challenging
  • Arm or leg weakness or numbness
  • Seizure
  • The skin or eyes turning yellow
  • Extreme fatigue
  • One leg only may experience pain, swell, warmth, redness, or discomfort
  • Bleeding during menstruation that is stronger or last longer than usual
  • Acute discomfort or soreness below the waist
  • Rash
  • Hives
  • Itching
  • Breathing or swallowing challenges
  • Edoema of the lower legs, ankles, feet, or hands
  • Frequent, painful, or challenging urinating
  • Persistent discomfort, pus, warmth, edoema, or bleeding at the site of the drug injection

You may have a slightly higher risk of developing breast cancer if you started taking medroxyprogesterone injections within the last four to five years and are under the age of 35. The administration of medroxyprogesterone may also raise your risk of developing a blood clot that travels to your lungs or brain. Discuss the dangers of using this drug with your doctor.

An effective method of long-acting birth control is medroxyprogesterone injection. Following your final injection, it’s possible that you won’t become pregnant for some time. If you intend to get pregnant soon, discuss the potential effects of using this medicine with your doctor.

Further negative effects from medroxyprogesterone injection are possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

The drug will be kept by your doctor in their office.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

At least once a year, you should have a thorough medical examination that includes taking your blood pressure, checking your pelvis and breasts, and getting a Pap test. When self-examining your breasts, adhere to your doctor’s instructions and report any lumps right away.

Inform the lab staff that you are using medroxyprogesterone prior to any laboratory tests.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Depo-Provera®
  • depo-subQ provera 104®
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