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Delstrigo (Generic Doravirine, Lamivudine, and Tenofovir)

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Delstrigo is a medication used to treat HIV-1 infection. Like any medication, it carries certain risks and potential side effects. Some of the risks associated with taking Delstrigo include:

  • Drug Interactions: Delstrigo can interact with other medications, including over-the-counter drugs and supplements. It’s essential to consult a healthcare provider before starting Delstrigo to avoid potential interactions.
  • Allergic Reactions: Some individuals may experience allergic reactions to Delstrigo, which can manifest as rash, itching, swelling, dizziness, or difficulty breathing. Seek medical attention if you experience any of these symptoms.
  • Liver Problems: Delstrigo can cause liver problems, including hepatotoxicity (liver damage). Symptoms may include yellowing of the skin or eyes, dark urine, abdominal pain, or unusual fatigue. Regular monitoring of liver function is necessary during Delstrigo treatment.
  • Immune Reconstitution Syndrome: In some HIV-infected patients with severe immune deficiency, signs and symptoms of inflammation from previous infections may occur soon after starting antiretroviral therapy, including Delstrigo. This is known as immune reconstitution syndrome.
  • Resistant Strains: As with any antiretroviral therapy, the development of drug-resistant HIV strains is possible if Delstrigo is not taken as prescribed or if the virus mutates. Adherence to the prescribed regimen is crucial to prevent the development of resistance.
  • Bone Loss: Some HIV medications, including components of Delstrigo, have been associated with decreased bone density and an increased risk of fractures. Regular monitoring and supplementation with calcium and vitamin D may be necessary.
  • Lactic Acidosis: In rare cases, Delstrigo can cause a condition called lactic acidosis, characterized by the buildup of lactic acid in the bloodstream. Symptoms may include weakness, unusual muscle pain, trouble breathing, stomach discomfort, nausea, vomiting, or feeling cold. Seek immediate medical attention if you experience these symptoms.

It’s important to discuss the risks and benefits of Delstrigo with a healthcare provider before starting treatment. Additionally, regular monitoring and communication with a healthcare team are essential to manage any potential risks effectively.

Why is this medication prescribed?

Delstrigo is a medication primarily prescribed to treat HIV-1 infection in adults who have never taken HIV medicine before. It’s a combination drug containing three active ingredients: doravirine, lamivudine, and tenofovir disoproxil fumarate. These medications work together to inhibit the replication of the HIV virus within the body, thereby helping to control the infection and reduce the risk of complications.

Doravirine belongs to a class of drugs called non-nucleoside reverse transcriptase inhibitors (NNRTIs), which target a specific enzyme necessary for HIV replication. Lamivudine and tenofovir are nucleoside reverse transcriptase inhibitors (NRTIs), which work by interfering with another enzyme required for the virus to replicate its genetic material.

How should this medicine be used?

Delstrigo is usually taken orally once daily with or without food. It’s important to take it exactly as prescribed by your healthcare provider, as adherence to the prescribed regimen is crucial for the medication to be effective in controlling HIV infection. Missing doses or not following the prescribed schedule could reduce the drug’s effectiveness and increase the risk of developing drug resistance.

It’s also essential to discuss any other medications, supplements, or medical conditions you have with your healthcare provider before starting Delstrigo, as it can interact with certain drugs or conditions. Additionally, regular monitoring of HIV infection status and overall health is typically recommended while taking Delstrigo. If you have any questions or concerns about your treatment with Delstrigo, it’s best to consult with your healthcare provider for personalized advice and guidance.

Other uses for this medicine

Delstrigo is specifically approved for the treatment of HIV-1 infection in adults who have not previously received antiretroviral therapy (ART). It’s not indicated for other uses besides HIV treatment. However, there may be instances where healthcare providers prescribe medications off-label for conditions not specifically approved by regulatory agencies. This should only be done based on careful consideration of the patient’s individual circumstances and with appropriate monitoring.

What special precautions should I follow?

As for special precautions when taking Delstrigo, here are some key points to consider:

  • Adherence: It’s crucial to take Delstrigo exactly as prescribed by your healthcare provider. Missing doses or not following the prescribed regimen can reduce the drug’s effectiveness and increase the risk of developing drug resistance.
  • Drug Interactions: Delstrigo can interact with other medications, including over-the-counter drugs, prescription medications, and herbal supplements. Before starting Delstrigo, inform your healthcare provider about all medications and supplements you are taking to avoid potentially harmful interactions.
  • Renal Function: Tenofovir, one of the components of Delstrigo, can affect kidney function. Your healthcare provider may monitor your kidney function regularly while you are taking this medication, especially if you have pre-existing kidney problems.
  • Hepatic Function: Doravirine, another component of Delstrigo, may affect liver function. If you have liver disease or hepatitis, your healthcare provider may monitor your liver function regularly while you are taking Delstrigo.
  • Pregnancy and Breastfeeding: The safety of Delstrigo during pregnancy and breastfeeding has not been established. If you are pregnant or planning to become pregnant, or if you are breastfeeding, discuss the risks and benefits of Delstrigo with your healthcare provider.
  • Immune Reconstitution Syndrome: When starting ART, including Delstrigo, some patients may experience immune reconstitution syndrome, where the body’s immune system begins to recover and responds to previously hidden infections or conditions. This can sometimes result in the worsening of symptoms or the appearance of new symptoms. If you experience any unusual symptoms after starting Delstrigo, inform your healthcare provider.
  • Side Effects: Like all medications, Delstrigo can cause side effects. Common side effects may include headache, diarrhea, nausea, fatigue, and abnormal dreams. If you experience severe or persistent side effects, contact your healthcare provider.

It’s important to communicate openly with your healthcare provider about any concerns or questions you have about taking Delstrigo. They can provide personalized guidance and support to help ensure the safe and effective use of this medication.

What special dietary instructions should I follow?

Special dietary instructions for Delstrigo are generally not required. You can take it with or without food. However, if you experience gastrointestinal discomfort, taking it with food may help alleviate these symptoms. Otherwise, there are no specific dietary restrictions associated with taking Delstrigo.

What should I do if I forget a dose?

If you forget to take a dose of Delstrigo, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you have any concerns or questions about missed doses, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Delstrigo, like any medication, can cause side effects. Common side effects of Delstrigo may include:

  • Headache
  • Diarrhea
  • Nausea
  • Fatigue
  • Abnormal dreams

These side effects are usually mild to moderate in severity and may improve as your body adjusts to the medication. However, if any of these side effects persist or worsen, it’s essential to inform your healthcare provider.

In addition to the common side effects, Delstrigo may also cause more serious side effects, although these are less common. These can include:

  • Changes in liver function tests
  • Allergic reactions, including rash, swelling, or difficulty breathing
  • Changes in kidney function
  • Worsening of hepatitis B virus infection (for individuals with hepatitis B)
  • Changes in body fat distribution

It’s crucial to report any unusual or severe symptoms to your healthcare provider promptly. They can assess whether the symptoms are related to Delstrigo and recommend appropriate management. Additionally, if you experience any signs of an allergic reaction, such as rash, itching, swelling, dizziness, or trouble breathing, seek immediate medical attention.

Remember that this list of side effects is not exhaustive. Always consult your healthcare provider or pharmacist for comprehensive information about potential side effects associated with Delstrigo, and report any unexpected symptoms while taking the medication.

What should I know about storage and disposal of this medication?

When it comes to storage and disposal of Delstrigo, here’s what you should know:

  • Storage: Store Delstrigo at room temperature between 68°F to 77°F (20°C to 25°C). Keep it in its original container, tightly closed, and away from moisture and light. Do not store Delstrigo in the bathroom or in places where it could be exposed to extreme heat or moisture. Keep it out of reach of children and pets.
  • Disposal: Dispose of unused or expired Delstrigo safely to prevent accidental ingestion by children, pets, or others. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Proper disposal typically involves mixing the medication with an undesirable substance (e.g., coffee grounds or kitty litter) in a sealed plastic bag and then placing it in the household trash. Some pharmacies and community centers may also offer medication take-back programs for safe disposal.

In case of emergency/overdose

  • Emergency Medical Attention: If you suspect an overdose or experience severe symptoms such as severe dizziness, fainting, irregular heartbeat, or difficulty breathing, seek emergency medical attention immediately. Call your local emergency services or go to the nearest emergency room.
  • Poison Control: You can also contact your local poison control center at 1-800-222-1222 (in the United States) for guidance on what to do in case of overdose. Have the medication container or label with you when you call for assistance.

What other information should I know?

  • Regular Monitoring: Your healthcare provider may perform regular monitoring of your HIV infection status, liver function, kidney function, and overall health while you are taking Delstrigo. Follow-up appointments and laboratory tests may be scheduled to ensure the medication is working effectively and to monitor for any potential side effects.
  • Drug Resistance: Taking Delstrigo as prescribed is essential to prevent the development of drug-resistant strains of HIV. Do not skip doses or stop taking the medication without consulting your healthcare provider, even if you feel better.
  • Transmission of HIV: Delstrigo does not cure HIV infection or prevent the transmission of HIV to others. Practice safe sex by using condoms and avoid sharing needles or other injection equipment to reduce the risk of transmitting HIV to others.
  • Consultation: Always consult your healthcare provider or pharmacist if you have any questions or concerns about taking Delstrigo, its side effects, or its interactions with other medications or conditions. They can provide personalized advice and guidance based on your individual circumstances.
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