PrescriptionGiant is a FREE prescription savings program that can save you up to 75% on your prescriptions with or without insurance!

Delstrigo (Generic Doravirine, Lamivudine, and Tenofovir)

Actual product appearance may differ slightly.

Click the CARD below to print or take a screenshot on your mobile phone or tablet. There is no need to download another app!


If you would like to personalize your card enter your full name in the member name field below the card at this link and click the Update button.


For the treatment of hepatitis B virus infection, doravirine, lamivudine, and tenofovir should not be administered together (HBV; an ongoing liver infection). If you suspect you may have HBV, let your doctor know. Before you start your therapy with doravirine, lamivudine, and tenofovir, your doctor may do a test to determine whether you have HBV. If you are taking doravirine, lamivudine, and tenofovir and have HBV, your condition could abruptly go worse if you stop taking them.

Keep all of your appointments with your physician and the lab. Before, throughout, and frequently for several months after you stop taking doravirine, lamivudine, and tenofovir, your doctor will check you and place lab test orders.

The risks of taking doravirine, lamivudine, and tenofovir should be discussed with your doctor.

Why is this medication prescribed?

Adults who have not had prior HIV drugs are treated for human immunodeficiency virus (HIV) infection with the tritherapy of doravirine, lamivudine, and tenofovir. In certain persons who are already taking HIV drugs, the combination is also utilised to replace the present medication regimen. A group of drugs known as non-nucleoside reverse transcriptase inhibitors includes doravirine (NNRTIs). Nucleoside reverse transcriptase inhibitors are a class of medicines that includes lamivudine and tenofovir (NRTIs). Doravirine, lamivudine, and tenofovir work together to reduce the body’s level of HIV. Although the tri-therapy of doravirine, lamivudine, and tenofovir does not cure HIV, it may lessen your risk of getting AIDS and other HIV-related conditions such serious infections or cancer. The danger of transferring the HIV virus to other people may be reduced by taking these medications, engaging in safer sexual behaviour, and altering other aspects of one’s lifestyle.

How should this medicine be used?

Doravirine, lamivudine, and tenofovir are available as a tablet that should be swallowed. It is typically taken once day, with or without food. Every day, take tenofovir, lamivudine, and doravirine at roughly the same time. Ask your doctor or chemist to explain any instructions on your prescription label that you are unsure about following. Doravirine, lamivudine, and tenofovir should be taken exactly as prescribed. Never take it in larger or less amounts or more frequently than directed by your doctor.

Doravirine, lamivudine, and tenofovir work together to control HIV infection, but they do not treat it. Even if you feel good, keep taking doravirine, lamivudine, and tenofovir. Without first seeing your doctor, do not discontinue taking doravirine, lamivudine, or tenofovir. Your condition could get worse if you stop taking doravirine, lamivudine, and tenofovir or miss doses. Ask your doctor or chemist for extra doravirine, lamivudine, and tenofovir when you run out of those medications.

For a copy of the manufacturer’s information for the patient, ask your chemist or doctor.

Other uses for this medicine

Ask your doctor or chemist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking doravirine, lamivudine, and tenofovir,

  • If you have an allergy to doravirine, lamivudine, tenofovir, any other medications, or any of the substances in doravirine, lamivudine, and tenofovir tablets, notify your doctor right away. Get a list of the ingredients from your chemist.
  • Inform your physician if you are also taking enzalutamide (Xtandi), mitotane (Lysodren), oxcarbazepine (Trileptal), phenobarbital, phenytoin (Dilantin, Phenytek), rifampin (Rifadin, Rimactane, in Rifamate, in Rifater), rifapentine (Priftin), or St. If you are presently on one or more of these drugs, or if you have recently taken one of them, your doctor will generally advise against taking doravirine, lamivudine, or tenofovir.
  • Inform your doctor and chemist about any additional prescription and over-the-counter medications, vitamins, herbal items, nutritional supplements, and other drugs you are now taking or intend to take. Any of the following should be mentioned: acyclovir (Sitavig, Zovirax); aminoglycosides such tobramycin, amikacin, gentamicin, and streptomycin; cidofovir, ganciclovir (Cytovene), aspirin, and other nonsteroidal anti-inflammatory drugs (NSAIDs) such ibuprofen (Advil, Motrin, and Naprosyn); sorbitol or drugs containing it, valacyclovir (Valtrex), sofosbuvir/velpatasvir (Epculsa), ledipasvir/sofosbuvir (Harvoni), and valganciclovir (Valcyte). If you are now taking rifabutin (Mycobutin) or have recently taken it, let your doctor know. Your doctor might need to adjust your medication doses or keep a close eye out for any negative side effects. Doravirine, lamivudine, and tenofovir may interact with numerous other drugs as well, so be sure to inform your doctor of all the drugs you are taking, even ones that are not on this list.
  • Inform your physician if you suffer from any of the conditions listed in the IMPORTANT WARNING section, or if you currently have or have previously had any bone issues, such as osteoporosis (a condition in which the bones become brittle and prone to fracture), kidney illness, or bone fractures.
  • Inform your doctor if you have or have previously had an illness that persists or flares up, such as the cytomegalovirus (CMV; a viral infection that can produce symptoms in people with weakened immune systems), mycobacterium avium complex disease (MAC; a bacterial infection like pneumonia or tuberculosis, which can have serious effects on AIDS patients, or an autoimmune disease like Graves’ disease, in which the body mistakenly attacks the thyroid gland and causes it to become overactive, or polymyositis, which causes the immune system to mistakenly attack healthy cells in the body (condition that causes muscle weakness but not skin rash), Guillain-Barré syndrome, autoimmune hepatitis, and weakness, tingling, and perhaps paralysis as a result of abrupt nerve injury (condition in which the cells of the immune system attack the liver).
  • If you are pregnant or plan to become pregnant, let your doctor know. Call your doctor if you become pregnant while taking doravirine, lamivudine, or tenofovir. Inform your doctor if you are nursing a child. If you have HIV or are taking doravirine, lamivudine, or tenofovir, you shouldn’t breastfeed.
  • You should be aware that while you use medications to treat your HIV infection, your immune system could become stronger and start to fight other infections you previously have in your body or trigger the development of other illnesses. You might start to exhibit signs of certain illnesses as a result of this. Tell your doctor right away if you experience any new or worsening symptoms while taking doravirine, lamivudine, or tenofovir.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

There could be negative effects from doravirine, lamivudine, and tenofovir. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Dizziness
  • Nausea
  • Strange dreams
  • Having trouble falling or staying asleep
  • Drowsiness
  • Diarrhea

Certain adverse effects can be very harmful. Call your doctor right away if you encounter any of these symptoms, or seek emergency care:

  • Reduced urination or leg edoema
  • Bone pain, arm or leg discomfort, ache or weakness in the muscles, or bone fracture

Further adverse effects could be brought on by doravirine, lamivudine, and tenofovir. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Keep it away from excessive heat and moisture at room temperature (not in the bathroom). Removing the desiccant (drying agent) from the bottle is not advised.

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your chemist or the garbage/recycling agency in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Doravirine, lamivudine, and tenofovir should always be available. Do not put off getting a refill on your prescription until you are out of medicine.

No one else should take your medication. Any queries you may have regarding prescription refills should be directed to your chemist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Delstrigo®
Copyright © 2023