PrescriptionGiant is a FREE prescription savings program that can save you up to 75% on your prescriptions with or without insurance!

Delestrogen (Generic Estrogen Injection)

Actual product appearance may differ slightly.

Click the CARD below to print or take a screenshot on your mobile phone or tablet. There is no need to download another app!

If you would like to personalize your card enter your full name in the member name field below the card at this link and click the Update button.


Delestrogen, also known as estradiol valerate, is a medication primarily used in hormone therapy for transgender women and in menopausal hormone therapy for women. Like any medication, it carries risks and potential side effects. Some of the risks associated with taking Delestrogen include:

  • Thromboembolic disorders: There’s an increased risk of blood clots, which can lead to serious conditions like stroke or pulmonary embolism.
  • Cardiovascular disorders: Long-term use may increase the risk of heart disease and related issues.
  • Breast cancer: There’s a potential increased risk of developing breast cancer, especially with long-term use.
  • Endometrial cancer: In women with intact uteri, unopposed estrogen therapy like Delestrogen may increase the risk of endometrial cancer.
  • Gallbladder disease: Estrogen therapy can increase the risk of gallbladder problems.
  • Liver problems: Estrogen can affect liver function, particularly in those with pre-existing liver conditions.
  • Fluid retention: Some individuals may experience fluid retention, which can lead to swelling and discomfort.
  • Mood changes: Estrogen therapy might affect mood and mental health in some individuals.

It’s crucial for individuals considering Delestrogen or any hormone therapy to discuss the potential risks and benefits thoroughly with their healthcare provider. Monitoring for any adverse effects during treatment is also essential for managing risks effectively.

Why is this medication prescribed?

Delestrogen, or estradiol valerate, is prescribed for several medical reasons, primarily related to hormone replacement therapy (HRT) in transgender women and menopausal hormone therapy (MHT) in women experiencing menopause. Here’s why it’s prescribed:

  • Feminization in transgender women: Delestrogen is used to help feminize the body in transgender women by supplementing estrogen levels, promoting the development of feminine secondary sexual characteristics such as breast growth and redistribution of body fat.
  • Menopausal hormone therapy: In menopausal women, Delestrogen is prescribed to alleviate symptoms of menopause, such as hot flashes, vaginal dryness, and mood changes. It can also help prevent bone loss (osteoporosis) associated with declining estrogen levels after menopause.

How should this medicine be used?

As for how Delestrogen should be used:

  • Dosage: The dosage of Delestrogen varies depending on the individual’s medical condition and response to treatment. It’s typically administered via intramuscular injection, either once every one to four weeks for transgender hormone therapy or as part of a cyclical or continuous regimen for menopausal hormone therapy.
  • Administration: Delestrogen injections are typically administered by a healthcare professional. They may provide instructions on self-injection if appropriate.
  • Monitoring: Regular monitoring by a healthcare provider is essential to assess the effectiveness of treatment and monitor for any potential side effects or complications.
  • Duration of use: The duration of Delestrogen therapy varies depending on the individual’s medical needs and response to treatment. It may be used temporarily during the transition process for transgender women or long-term for menopausal hormone therapy, with periodic reevaluation by a healthcare provider.

It’s crucial for individuals prescribed Delestrogen to follow their healthcare provider’s instructions carefully, attend regular follow-up appointments, and communicate any concerns or changes in symptoms during treatment.

Other uses for this medicine

Delestrogen may be used off-label for conditions such as breast cancer, prostate cancer, or transgender hormone therapy. However, its use for these purposes would be determined by a healthcare provider based on individual circumstances.

What special precautions should I follow?

Regarding special precautions for Delestrogen, it’s essential to follow these guidelines:

  • Medical history: Before starting Delestrogen therapy, inform your healthcare provider about your complete medical history, including any past or present medical conditions, allergies, surgeries, and medications you are currently taking.
  • Regular check-ups: Regularly scheduled check-ups with your healthcare provider are important to monitor your response to treatment and to watch for any potential side effects or complications.
  • Risk assessment: Your healthcare provider will assess your individual risk factors before prescribing Delestrogen, especially considering factors such as age, smoking history, personal or family history of blood clots, cardiovascular disease, breast cancer, or other conditions that may be affected by estrogen therapy.
  • Monitoring: During Delestrogen therapy, your healthcare provider may monitor your blood pressure, cholesterol levels, and other relevant parameters to ensure your safety and wellbeing.
  • Avoid smoking: Smoking increases the risk of serious cardiovascular side effects associated with estrogen therapy. If you smoke, quitting is highly recommended.
  • Alert your healthcare provider: Notify your healthcare provider immediately if you experience any unusual symptoms, such as chest pain, shortness of breath, severe headaches, vision changes, leg swelling, or signs of an allergic reaction (e.g., rash, itching, swelling).

By following these precautions and staying in close communication with your healthcare provider, you can help ensure the safe and effective use of Delestrogen therapy for your specific medical needs.

What special dietary instructions should I follow?

Regarding special dietary instructions for Delestrogen, there are no specific dietary restrictions associated with its use. However, maintaining a healthy and balanced diet as recommended by your healthcare provider is important for overall health and well-being.

What should I do if I forget a dose?

If you forget a dose of Delestrogen, contact your healthcare provider or pharmacist for guidance. They may advise you on when to take the missed dose or if any adjustments to your dosing schedule are necessary. It’s essential not to double up on doses unless instructed to do so by your healthcare provider. Consistency in your dosing schedule is important for the effectiveness of hormone therapy.

What side effects can this medication cause?

Delestrogen, like any medication, can cause side effects, although not everyone will experience them. Common side effects of Delestrogen may include:

  • Nausea and vomiting: Some individuals may experience gastrointestinal discomfort, including nausea and vomiting, especially when starting treatment.
  • Breast tenderness or enlargement: Delestrogen can cause breast tenderness or enlargement (gynecomastia) in both men and women.
  • Fluid retention: Some individuals may experience fluid retention, leading to swelling in the hands, ankles, or feet.
  • Headaches: Headaches are a common side effect of estrogen therapy and may occur during treatment with Delestrogen.
  • Mood changes: Estrogen therapy can affect mood and emotional well-being in some individuals, leading to mood swings or changes in affect.
  • Changes in libido: Some individuals may experience changes in sexual desire or libido while taking Delestrogen.
  • Irregular vaginal bleeding: Women may experience irregular vaginal bleeding or spotting, especially during the first few months of treatment.
  • Skin changes: Estrogen therapy can affect the skin, leading to changes such as acne or increased pigmentation.
  • Fatigue: Some individuals may experience fatigue or tiredness as a side effect of Delestrogen therapy.
  • Weight changesv Changes in weight, including weight gain or weight loss, may occur with estrogen therapy.

It’s important to note that some individuals may experience more severe side effects or allergic reactions to Delestrogen. These can include:

  • Severe allergic reactions, such as rash, itching, swelling of the face, tongue, or throat, severe dizziness, or trouble breathing.
  • Blood clots, which can manifest as pain, warmth, redness, or swelling in the legs, chest pain, sudden shortness of breath, or coughing up blood.

If you experience any severe or concerning side effects while taking Delestrogen, it’s important to seek medical attention promptly. Your healthcare provider can provide guidance on managing side effects and adjusting your treatment as needed.

What should I know about storage and disposal of this medication?

Storage and disposal of Delestrogen:

  • Storage: Store Delestrogen vials at room temperature away from light and moisture. Avoid freezing. Keep it out of reach of children and pets.
  • Disposal: Dispose of unused or expired Delestrogen vials according to local regulations. Do not flush them down the toilet or pour them into a drain unless instructed to do so. Ask your healthcare provider or pharmacist about the proper disposal method.

In case of emergency/overdose

  • Seek medical attention: If you suspect an overdose or experience severe symptoms such as difficulty breathing, chest pain, or loss of consciousness, seek immediate medical help or call your local emergency services.
  • Poison control: If you believe someone has overdosed on Delestrogen, contact your local poison control center or emergency department for guidance.

What other information should I know?

  • Regular monitoring: Your healthcare provider may schedule regular check-ups and blood tests to monitor your response to Delestrogen therapy and watch for any potential side effects or complications.
  • Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with Delestrogen. This includes prescription and over-the-counter medications.
  • Medical alert: If you undergo surgery or medical procedures, inform healthcare providers about your use of Delestrogen, as it may affect treatment decisions.
  • Pregnancy and breastfeeding: Delestrogen is not recommended for use during pregnancy or breastfeeding unless specifically prescribed by a healthcare provider, as it may harm the fetus or nursing infant.
  • Follow instructions: Take Delestrogen exactly as prescribed by your healthcare provider. Do not change your dose or stop taking it without consulting your healthcare provider first.
  • Communication: Keep an open line of communication with your healthcare provider. Discuss any concerns or changes in symptoms you experience during Delestrogen therapy.

By following these guidelines and staying informed about Delestrogen, you can help ensure the safe and effective use of this medication for your specific medical needs.

Copyright © 2023