The kidneys may suffer substantial or perhaps fatal harm from deferasirox. If you have a number of illnesses or are in really bad health due to a blood condition, your risk of developing kidney impairment is higher. If you have renal illness now or ever have, let your doctor know. You could be advised by your doctor not to take deferasirox. Call your doctor right away if you suffer any of the following signs: reduced urination, ankle, leg, or foot edoema, severe fatigue, shortness of breath, or confusion. If you get sick while using deferasirox and experience diarrhoea, vomiting, fever, or stop drinking fluids normally, there is a higher risk that you will develop kidney problems. If you encounter any of these signs, call your doctor right once.

The liver may suffer severe or maybe fatal harm as a result of deferasirox. If you are older than 55 years old or have other major medical conditions, your risk of developing liver damage is higher. If you have liver illness now or ever had it, let your doctor know. Call your doctor right away if you experience any of the following signs or symptoms: Skin or eye yellowing, flu-like symptoms, fatigue, appetite loss, pain in the upper right portion of the stomach, or unusual bleeding or bruising.

Deferasirox may also result in severe or even fatal stomach or intestinal haemorrhage. If you are elderly or in severe condition due to a blood problem, your risk of experiencing serious stomach or intestine bleeding may be higher. Inform your doctor if you are currently taking any of the following drugs, have ever had low platelet counts (a kind of blood cell necessary to stop bleeding), or have ever experienced low platelet counts. blood thinners known as anticoagulants, such as warfarin (Coumadin, Jantoven); aspirin or other NSAIDs like ibuprofen (Advil, Motrin, and other brands) and naproxen (Aleve, Naprosyn, and other brands); a number of bone-strengthening drugs, such as zoledronic acid (Reclast, Zometa), alendronate (Binosto, Fosamax), etidronate, ibandronate (Boniva), pamidronate, risedronate (Actonel, Atelvia), and zoledronate (Binosto, Fosamax), as well as steroids such dexamethasone, methylpre (Rayos). Call your doctor right away if you have any of the following symptoms: bright red or coffee-ground-colored vomit, bright red blood in the faeces, or black or tarry stools are all symptoms of a burning stomach.

Keep all of your appointments with the lab and your doctor. Your doctor will ask for laboratory testing both before and during your treatment to ensure that taking deferasirox is safe for you and to check whether you are experiencing any serious side effects.

Those who have too much iron in their bodies as a result of frequent blood transfusions are treated with deferirox in adults and children 2 years of age and older. Moreover, non-transfusion-dependent thalassemia, a genetic blood condition, is treated with it in adults and children aged 10 and older who have an excess of iron in their bodies (NTDT). Iron chelators are a group of drugs that includes deferasirox. In order for iron to be expelled (taken from the body) in faeces, it binds to iron in the body.

In addition to tablets, Deferasirox is also available in granules and tablets for oral suspension (tablets that dissolve in liquid). Once daily, it should be taken without food and at least 30 minutes before a meal. The tablets and granules can also be taken with a small turkey sandwich on whole wheat toast or a whole wheat English muffin with jelly and skim milk. Deferasirox should be taken every day at around the same time. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Follow the deferasirox directions exactly. Never take it in larger or less amounts or more frequently than directed by your doctor.

Because different deferasirox products are absorbed by the body in various ways, they cannot be interchanged. Your doctor might need to change your dose if you need to transition from one deferasirox product to another. Verify that you have received the deferasirox product prescribed for you each time you receive a dose of medication. If you are unsure if you were given the correct medication, speak with your pharmacist.

Deferasirox pills (Jadenu) should be taken with water or another drink. If you have problems swallowing the tablet, you can crush it and combine it right before eating it with a soft food, like yoghurt or applesauce. Therefore, avoid using a commercial crushing tool with rough edges to break the 90 mg tablet (Jadenu).

While using deferasirox granules (Jadenu), immediately before ingesting, sprinkle the granules on a soft food, such as yoghurt or applesauce.

Follow these instructions to take deferasirox tablets for suspension (Exjade):

1. When taking the pills for suspension, always dissolve them in a drink. The suspension tablets should not be chewed or swallowed whole.
2. Fill a cup halfway (about 3.5 oz/100 mL) with water, apple juice, or orange juice if you are taking less than 1000 mg of deferasirox daily. Fill a cup (about 7 oz/200 mL) with water, apple juice, or orange juice if you’re taking more than 1000 mg of deferasirox daily. Ask your doctor or pharmacist if you’re unsure how much deferasirox to take.
3. Put the number of tablets your doctor has instructed you to take in the cup.
4. For the tablets to thoroughly dissolve, stir the mixture for three minutes. As you whisk the mixture, it might become thick.
5. Take the drink right away.
6. Fill the empty cup with a tiny amount of liquid, then mix. Any medication that is left in the glass or on the stirrer should be dissolved by swishing the cup.
7. Consume the remaining liquid.

Depending on the outcomes of your laboratory tests, your doctor may change your deferasirox dosage no more frequently than once every three to six months.

Your body gradually loses additional iron as a result of deferirox use. Deferasirox should still be taken even if you feel fine. Without consulting your doctor, do not discontinue taking deferasirox.

Ask your doctor or chemist for more details if you believe this drug should be used for something else.

Before taking deferasirox,

• If you have any allergies, including to any of the substances in deferasirox tablets, granules, or tablets for suspension, notify your doctor right away. For a list of the ingredients, ask your doctor or chemist.
• Inform your doctor and chemist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products that you are now taking or intend to use. Mention the drugs in the IMPORTANT CAUTION section as well as any of the following: Budesonide (Entocort, Pulmicort, Uceris, in Symbicort), alosetron (Lotronex), aprepitant (Cinvanti, Emend), buspirone, and cholestyramine (Prevalite), Darifenacin (Enablex), darunavir (Prezista, in Prezcobix), dasatinib (Sprycel), cyclosporine (Gengraf, Neoral, Sandimmune), colesevelam (Welchol), colestipol (Colestid), conivaptan (Vaprisol), dihydroergotamine (D.H.E. 45, Migranal), everolimus (Afinitor, Zortress), felodipine, fentanyl (Actiq, Duragesic, Subsys, others), fluticasone, dronedarone, duloxetine (Cymbalta), eletriptan (Relpax), eplerenone (Inspra), ergotamine (Ergomar, in Cafergot, Migergot), ergotamine sulphate (Ergomar (Arnuity Ellipta, Flovent, in Breo Ellipta, Advair), hormonal birth control (pills, rings, patches, or injections), lovastatin (Altoprev), lurasidone (Latuda), maraviroc (Selzentry), midazolam, and nisoldipine are all examples of contraceptives (Sular), phenobarbital, pimozide (Orap), quetiapine (Seroquel), quinidine (in Nuedexta), phenytoin (Dilantin, Phenytek), paclitaxel (Abraxane, Taxol), ramelteon (Rozerem), rifampin (Rimactane, Rifadin, in Rifamate, in Rifater), repaglinide (Prandin, in Prandimet), ritonavir (Norvir, in Kaletra, technivie, theophylline (Theo-24), ticagrelor (Brilinta), tipranavir (Aptivus), tizanidine (Zanaflex), triazolam (Halcion), tolvaptan (Samsca), and vardenafil are examples of medications that are included in this class. Saquinavir (Invirase), sildenafil (Revatio, Viagra), simvastatin (Flolopid (Levitra, Staxyn). Your doctor might need to adjust your medication doses or keep a close eye out for any negative side effects.
• Amphojel, Alternagel, Gaviscon, Maalox, or Mylanta are examples of aluminum-containing antacids that should be taken 2 hours prior to or after deferasirox.
• Let your doctor know if you’re using any over-the-counter medications, notably melatonin or caffeine supplements.
• Inform your doctor if you have cancer or myelodysplastic syndrome, a serious bone marrow condition that has a high risk of turning into cancer. You could be advised by your doctor not to take deferasirox.
• Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. Call your doctor if you become pregnant while taking deferasirox.

Keep eating normally unless your doctor instructs you otherwise.

Take the missed dose later in the day, at least two hours after your previous meal, and at least 30 minutes before your next meal. To resume your regular dosing plan, skip the missed dose if it is almost time for the next dose or if you won’t be able to take deferasirox on an empty stomach. To make up for a missing dose, do not take a second one.

Side effects are possible with deferirox. If any of these symptoms are severe or do not go away, let your doctor know right once:

• Abdominal pain
• Nausea
• Vomiting
• Diarrhea

Certain adverse effects can be very harmful. Call your doctor right away if you encounter any of these signs or those listed in the IMPORTANT CAUTION section:

• Loss of hearing
• Vision issues
• Hives, skin that is peeling or blistering, a rash, a fever, or swollen lymph nodes
• Swelling of the face, throat, tongue, lips, or eyes, trouble breathing or swallowing, and hoarseness
• Significant bruising or bleeding

Further negative effects of deferasirox are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

Keep this medication tightly closed in the original container and out of the reach of children. Keep it away from excessive heat and moisture at room temperature (not in the bathroom).

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning. http://www.upandaway.org

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at http://goo.gl/c4Rm4p for additional information.

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

• Eyes or skin that have a yellow tint
• Stomach ache in the top right corner
• Significant bruising or bleeding
• Not enough energy
• Reduced appetite
• Flu-like signs
• Diarrhoea
• Nausea
• Vomiting
• Less urinations
• Ankle or leg swelling

Keep all of your doctor’s appointments. Before starting deferasirox and once a year while taking this medicine, you must have hearing and vision exams.

No one else should take your medication. Any queries you may have regarding prescription refills should be directed to your chemist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.