PrescriptionGiant is a FREE prescription savings program that can save you up to 75% on your prescriptions with or without insurance!

Decitabine Injection

Actual product appearance may differ slightly.

Click the CARD below to print or take a screenshot on your mobile phone or tablet. There is no need to download another app!

If you would like to personalize your card enter your full name in the member name field below the card at this link and click the Update button.

Why is this medication prescribed?

Decitabine injection is typically prescribed to treat certain types of blood/bone marrow disorders, including myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). These conditions involve abnormal production and maturation of blood cells, which can lead to symptoms like anemia, easy bruising or bleeding, and increased risk of infections. Decitabine works by helping to restore normal growth and function to blood cells.

How should this medicine be used?

Decitabine injection is typically administered by a healthcare professional in a hospital or clinical setting. Here’s a general guideline on how decitabine injection is used:

  • Preparation: The healthcare provider will prepare the medication according to the prescribed dosage and dilute it with a compatible intravenous fluid, if necessary.
  • Administration: Decitabine is given as an intravenous infusion, meaning it’s injected slowly into a vein over a period of time. The infusion may take about 1 hour to complete.
  • Frequency: The frequency of decitabine injections and the duration of treatment depend on the specific condition being treated and your individual response to the medication. Treatment may be given daily for a certain number of days, followed by a rest period before starting the next cycle. Your doctor will determine the appropriate schedule for you.
  • Monitoring: During treatment with decitabine, your healthcare team will monitor your blood counts and overall health regularly to assess the response to the medication and manage any side effects that may occur.
  • Follow-up: It’s important to attend all scheduled appointments with your healthcare provider to ensure that you receive the full benefit of the treatment and to address any concerns or questions you may have.
  • Storage: Decitabine injection should be stored according to the instructions provided by the pharmacist or healthcare provider. It’s typically stored at room temperature away from light and moisture.

Always follow your doctor’s instructions regarding the use of decitabine injection and ask any questions you may have about the treatment. If you have concerns about the administration process or experience any side effects, be sure to discuss them with your healthcare provider promptly.

Other uses for this medicine

Some off-label uses of decitabine injection may include:

  • Treatment of chronic myelomonocytic leukemia (CMML), a type of blood cancer that shares characteristics of both MDS and AML.
  • Investigational use in other hematological malignancies or solid tumors, particularly in clinical trials exploring its efficacy in combination with other drugs.

What special precautions should I follow?

Special precautions should be observed when using decitabine injection:

  • Pregnancy and breastfeeding: Decitabine may harm an unborn baby. Therefore, it’s crucial to avoid becoming pregnant while receiving treatment and to use effective contraception during treatment. It’s also not recommended to breastfeed while receiving decitabine.
  • Bone marrow suppression: Decitabine can cause severe bone marrow suppression, leading to low blood cell counts (neutropenia, thrombocytopenia, anemia). Regular blood tests are necessary to monitor blood counts during treatment. Your doctor may adjust the dosage or temporarily stop treatment if blood cell counts drop too low.
  • Liver and kidney function: Decitabine is primarily metabolized in the liver and excreted via the kidneys. Patients with impaired liver or kidney function may require dosage adjustments or closer monitoring during treatment.
  • Infections: Because decitabine can lower blood cell counts, patients are at increased risk of developing infections. It’s important to avoid contact with people who have infections and to promptly report any signs of infection, such as fever or chills, to your healthcare provider.
  • Bleeding: Due to the potential for decreased platelet counts, patients may experience an increased risk of bleeding. Precautions should be taken to avoid injury, and any signs of bleeding should be reported to the healthcare provider.
  • Other medications and supplements: Inform your doctor about all medications, vitamins, and supplements you are taking before starting decitabine treatment, as some drugs may interact with decitabine, potentially affecting its efficacy or increasing the risk of side effects.

Always follow your doctor’s instructions and discuss any questions or concerns you have about decitabine treatment, including its potential risks and benefits.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Decitabine Injection. However, maintaining a well-balanced diet rich in nutrients can support overall health and help manage potential side effects of treatment, such as fatigue and decreased appetite.

What should I do if I forget a dose?

If you miss a dose of Decitabine Injection, contact your healthcare provider or treatment team for guidance. They will advise you on the appropriate course of action, which may include rescheduling the missed dose or adjusting the treatment schedule. It’s essential to follow their instructions closely to ensure the effectiveness of your treatment regimen. Avoid doubling the dose to make up for a missed one without consulting your healthcare provider first.

What side effects can this medication cause?

Decitabine injection, like any medication, can cause side effects. Not everyone will experience these side effects, and their severity can vary from person to person. Common side effects of Decitabine Injection may include:

  • Low blood cell counts: Decitabine can cause bone marrow suppression, leading to decreased levels of white blood cells (neutropenia), red blood cells (anemia), and platelets (thrombocytopenia). This can increase the risk of infections, fatigue, and easy bruising or bleeding.
  • Nausea and vomiting: Some individuals may experience nausea, vomiting, or loss of appetite while receiving Decitabine treatment.
  • Fatigue: Feeling tired or fatigued is a common side effect of Decitabine Injection.
  • Injection site reactions: Pain, redness, or swelling at the injection site may occur.
  • Fever: Some patients may develop a fever as a side effect of Decitabine treatment.
  • Diarrhea or constipation: Changes in bowel habits, including diarrhea or constipation, can occur.
  • Mouth sores: Some individuals may develop sores or ulcers in the mouth or throat.
  • Skin rash or itching: Skin reactions such as rash or itching may occur.
  • Hair loss: Some patients may experience hair loss (alopecia) as a side effect of Decitabine treatment.
  • Liver or kidney problems: Decitabine can affect liver or kidney function in some individuals, leading to elevated liver enzymes or changes in kidney function tests.
  • Neurological effects: Rarely, Decitabine treatment may cause neurological side effects such as dizziness, confusion, or seizures.

It’s essential to report any side effects you experience to your healthcare provider, as they can provide guidance on managing these symptoms and may adjust your treatment regimen if necessary. In some cases, your healthcare provider may prescribe medications to help alleviate side effects or recommend supportive care measures. Additionally, some side effects may require immediate medical attention, so it’s important to seek prompt medical care if you experience severe or concerning symptoms while receiving Decitabine treatment.

What should I know about storage and disposal of this medication?

Storage and disposal of Decitabine Injection:

  • Storage: Decitabine Injection should be stored at room temperature between 20°C to 25°C (68°F to 77°F). It should be protected from light and kept in its original packaging until ready to use. Do not freeze Decitabine Injection. Keep it out of the reach of children and pets.
  • Disposal: Proper disposal of unused Decitabine Injection and any materials used to administer the medication (e.g., syringes, needles) is important to prevent accidental exposure. Follow local regulations or guidelines for the disposal of hazardous waste. Your healthcare provider or pharmacist can provide information on safe disposal methods.

In case of emergency/overdose

If you suspect an overdose or experience severe side effects after receiving Decitabine Injection, seek emergency medical attention or contact your local poison control center immediately. Symptoms of overdose may include severe bone marrow suppression leading to profound decreases in blood cell counts, which can result in increased risk of infections, bleeding, and other complications. It’s important to report any symptoms or concerns to your healthcare provider promptly.

What other information should I know?

  • Follow-up appointments: Attend all scheduled follow-up appointments with your healthcare provider to monitor your response to Decitabine treatment and manage any side effects or complications.
  • Laboratory tests: Regular blood tests are necessary to monitor blood cell counts and assess the effectiveness of Decitabine treatment. Your healthcare provider will determine the frequency of these tests based on your individual needs.
  • Drug interactions: Inform your healthcare provider about all medications, vitamins, and supplements you are taking, as Decitabine may interact with certain drugs, potentially affecting its effectiveness or increasing the risk of side effects.
  • Avoid live vaccines: Avoid receiving live vaccines while receiving Decitabine treatment, as they may pose an increased risk of infection. Discuss vaccination schedules with your healthcare provider.
  • Pregnancy and breastfeeding: Decitabine can harm unborn babies, so it’s important to avoid pregnancy during treatment and use effective contraception. Decitabine may also pass into breast milk, so breastfeeding is not recommended during treatment.
  • Driving and operating machinery: Decitabine treatment may cause dizziness or drowsiness in some individuals. Use caution when driving or operating machinery until you know how Decitabine affects you.

Always follow your healthcare provider’s instructions and ask any questions you may have about Decitabine Injection and your treatment plan.

Copyright © 2023