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DDP (Generic Cisplatin Injection)

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Cisplatin injection must be administered in a hospital or other healthcare institution under the direction of a physician with training in administering chemotherapy drugs for cancer.

Cisplatin may seriously damage renal function. Older persons may experience kidney issues more frequently. To determine whether this drug has an impact on your kidneys, your doctor will request laboratory testing both before and throughout your therapy. If you have renal illness now or ever have, let your doctor know. If you use aminoglycoside antibiotics such tobramycin, gentamicin, or amikacin (Amikin), let your doctor and chemist know (Tobi, Nebcin). Call your doctor right away if you have any of the following symptoms: reduced urination, face, arm, hand, foot, ankle, or lower leg edoema, unusual fatigue, or weakness.

Particularly in children, cisplatin has the potential to seriously impair hearing. In rare circumstances, hearing loss could be permanent. Before and after your treatment, your doctor will conduct tests to check on your hearing. If you have ever undergone head radiation therapy, tell your doctor and chemist. If you use aminoglycoside antibiotics such tobramycin, gentamicin, or amikacin (Amikin), let your doctor and chemist know (Tobi, Nebcin). Dial your doctor right once if you develop any of the following signs: hearing loss, ringing in the ears, or dizziness.

If you have already gotten multiple injections of cisplatin, you may experience severe adverse responses. The following symptoms could appear if you have an adverse response to cisplatin injection and could start a few minutes after your infusion begins: Hives, skin rashes, itching, skin reddening, breathing or swallowing issues, swelling of the face, throat, tongue, or lips, feeling faint or dizzy, or a rapid heartbeat. In the event that you suffer any of these signs, contact your doctor right once.

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to cisplatin, your doctor will prescribe specific tests prior to, during, and after your treatment. If you have particular adverse effects, your doctor may decide to halt or postpone your treatment.

Why is this medication prescribed?

Testicular cancer that has not improved or that has gotten worse after treatment with other medications or radiation therapy is treated with cisplatin in combination with other drugs. After receiving treatment with other drugs or radiation therapy, cancer of the ovaries a cancer that starts in the female reproductive organs where eggs are produced that has not improved or worsened is treated with the drug cisplatin alone or in combination with other drugs. For bladder cancer that cannot be treated with surgery or radiation therapy alone, cisplatin is also used alone or in combination with other medicines. Cisplatin belongs to a group of drugs called platinum-containing compounds. By delaying or halting the growth of cancer cells, it combats cancer.

How should this medicine be used?

A doctor or nurse will administer cisplatin injection intravenously (into a vein) over the course of 6 to 8 hours in a medical setting. Usually, it is administered once every three to four weeks.

Other uses for this medicine

In addition to lung cancer, cancer of the cervix and oesophagus, brain tumours, malignant pleural mesothelioma (cancer in the lining of the chest or abdomen), and neuroblastoma, cisplatin may also be used to treat head and neck cancer, cancers of the mouth, lip, cheek, tongue, palate, throat, tonsils, and sinuses (a cancer that begins in nerve cells and occurs mainly in children). When using this drug to treat your disease, discuss the risks with your doctor.

Ask your doctor or chemist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking cisplatin,

  • If you have an allergy to cisplatin, carboplatin (Paraplatin), any other drugs, or any of the chemicals in cisplatin injection, let your doctor and pharmacist know right once. Get a list of the ingredients from your chemist.
  • Inform your doctor and chemist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Mention the drugs in the IMPORTANT CAUTION section as well as any of the following: ambotericin B (Abelcet; AmBisome; amphotec, Fungizone Intravenous, phenytoin (Dilantin), bumetanide (Bumex), ethacrynic acid (Edecrin), furosemide (Lasix), and pyridoxine are examples of anticonvulsants (Vitamin B-6). Your doctor might need to adjust your medication doses or keep a close eye out for any negative side effects. Tell your doctor about all of your current medications, even those not on this list, as many additional drugs may also interact with cisplatin.
  • If you have kidney illness or hearing issues, let your doctor know. The injection of cisplatin might not be recommended by your doctor.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. While getting cisplatin, you shouldn’t get pregnant or breastfeed. Call your doctor if you fall pregnant while taking cisplatin. The foetus could suffer from cisplatin.

What side effects can this medication cause?

Cisplatin could have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Nausea
  • Vomiting
  • Diarrhea
  • Hair loss
  • deterioration of food taste
  • Hiccups
  • Dehydration symptoms include dry mouth, dark urine, decreased sweating, dry skin, and other symptoms.

Certain adverse effects can be very harmful. Call your doctor right away if you have any of these signs or any of those in the IMPORTANT CAUTION section:

  • Pain, redness, stinging, or swelling at the injection site
  • Hands or feet tingling, burning, or pain
  • Muscular pain
  • Having trouble walking
  • Shock-like electric sensation when you incline your neck forward
  • Seizures
  • Abrupt alterations in eyesight, including colour perception
  • Absence of vision
  • Eye discomfort
  • Chest pressure or pain
  • Fever, chills, a sore throat, or other symptoms of infection
  • Uncommon bruising or bleeding
  • Stool that is dark and tarry
  • Bench with a reddish tint
  • Tainted vomit
  • Vomited substance that resembles coffee grounds

Cisplatin may make you more likely to get other cancers. The dangers of using this drug should be discussed with your doctor.

Further negative effects of cisplatin are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Symptoms of an overdose may include:

  • Less urinations
  • Edoema of the lower legs, lower arms, hands, feet, ankles, or face
  • Unexpected fatigue or weakened state
  • Eyes or skin that have a yellow tint
  • Stomach ache in the top right corner
  • Nausea
  • Vomiting
  • Uncommon bruising or bleeding
  • Hearing issues
  • Abrupt alterations in eyesight
  • Fever, chills, a sore throat, or other symptoms of infection
  • Hands or foot pain, burning, numbness, or tingling

What other information should I know?

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Platinol®
  • Platinol-AQ®
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