PrescriptionGiant is a FREE prescription savings program that can save you up to 75% on your prescriptions with or without insurance!

DDAVP (Generic Desmopressin Nasal)

Actual product appearance may differ slightly.

Click the CARD below to print or take a screenshot on your mobile phone or tablet. There is no need to download another app!

If you would like to personalize your card enter your full name in the member name field below the card at this link and click the Update button.


Desmopressin Nasal is a medication primarily used to treat conditions like diabetes insipidus and bedwetting. While generally safe when used as prescribed, there are some risks associated with its use:

  • Fluid Overload: Desmopressin can cause water retention, leading to fluid overload, especially in individuals with conditions such as heart failure or kidney problems.
  • Hyponatremia: Excessive water retention can dilute the body’s sodium levels, resulting in a condition called hyponatremia. This can cause symptoms like confusion, headaches, nausea, and in severe cases, seizures or coma.
  • Hypertension: Desmopressin may lead to increased blood pressure, particularly in individuals who are already hypertensive or prone to hypertension.
  • Nasal Irritation: As Desmopressin is administered via nasal spray, there is a risk of nasal irritation, congestion, or nosebleeds.
  • Allergic Reactions: Though rare, some individuals may experience allergic reactions to Desmopressin Nasal, which can manifest as rash, itching, swelling, or difficulty breathing.

It’s crucial to use Desmopressin Nasal under the guidance of a healthcare professional and to follow dosage instructions carefully to minimize these risks. Regular monitoring and communication with your healthcare provider can help manage any potential side effects effectively.

Why is this medication prescribed?

Desmopressin Nasal is prescribed for several conditions:

  • Diabetes Insipidus: This medication is often used to manage central diabetes insipidus, a condition characterized by excessive urination and extreme thirst due to a deficiency of vasopressin, a hormone that regulates water balance in the body.
  • Nocturnal Enuresis: Desmopressin Nasal can also be prescribed for bedwetting (nocturnal enuresis) in children and adults who haven’t responded to other treatments. It helps reduce the production of urine during sleep.
  • von Willebrand Disease: In some cases, Desmopressin Nasal is used to treat bleeding disorders like von Willebrand disease by promoting the release of von Willebrand factor and factor VIII, which are important for blood clotting.

How should this medicine be used?

Desmopressin Nasal should be used exactly as prescribed by a healthcare professional. Here are some general guidelines:

  • Dosage: The dosage will depend on the condition being treated, the individual’s response to the medication, and other factors. It’s important to follow the prescribed dosage carefully.
  • Administration: Desmopressin Nasal comes in the form of a nasal spray. It is administered into the nostrils according to the instructions provided with the medication.
  • Timing: The timing of doses will vary depending on the condition being treated. For bedwetting, Desmopressin is often taken before bedtime. For diabetes insipidus, the dosage frequency and timing will be determined by the healthcare provider.
  • Monitoring: Regular monitoring by a healthcare professional is essential to ensure that the medication is working effectively and to watch for any potential side effects or complications.
  • Hydration: It’s important to maintain adequate hydration while taking Desmopressin Nasal, especially in hot weather or during strenuous activity, to prevent dehydration.

Always consult with a healthcare provider for specific instructions on how to use Desmopressin Nasal properly for your particular condition.

Other uses for this medicine

In addition to the primary uses mentioned earlier, Desmopressin Nasal may also be prescribed off-label for certain other conditions, such as:

  • Primary Nocturnal Enuresis: This refers to bedwetting in individuals who do not have any underlying medical conditions contributing to their nighttime urinary incontinence.
  • Central Cranial Diabetes Insipidus: Desmopressin Nasal can also be used to manage diabetes insipidus caused by conditions affecting the pituitary gland or hypothalamus.
  • Bleeding Disorders: In some cases, Desmopressin Nasal may be used to treat bleeding disorders other than von Willebrand disease, such as hemophilia A.

What special precautions should I follow?

Special precautions should be followed when using Desmopressin Nasal:

  • Medical History: Before using Desmopressin Nasal, inform your healthcare provider about any medical conditions you have, especially kidney problems, heart disease, high blood pressure, or conditions that affect fluid balance.
  • Allergies: Inform your doctor about any allergies you have, particularly to medications, as Desmopressin Nasal may contain inactive ingredients that could cause allergic reactions.
  • Fluid Intake: Maintain adequate fluid intake as directed by your healthcare provider to prevent dehydration or electrolyte imbalances, especially when using Desmopressin Nasal for conditions like diabetes insipidus.
  • Blood Pressure Monitoring: Regularly monitor your blood pressure while using Desmopressin Nasal, as it may cause increases in blood pressure, particularly in individuals with pre-existing hypertension.
  • Nasal Precautions: Use caution when administering Desmopressin Nasal, and avoid spraying it too forcefully to minimize the risk of nasal irritation or nosebleeds.
  • Medication Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as Desmopressin Nasal may interact with certain drugs, including antidepressants, NSAIDs, and drugs that affect blood clotting.

Always follow your healthcare provider’s instructions and guidelines for using Desmopressin Nasal safely and effectively. If you have any questions or concerns about its use, don’t hesitate to consult your healthcare provider.

What special dietary instructions should I follow?

Special dietary instructions for Desmopressin Nasal typically involve maintaining a balanced diet and adequate fluid intake unless otherwise directed by your healthcare provider. It’s essential to follow any dietary advice provided by your doctor, especially if you have specific dietary restrictions or requirements due to underlying medical conditions.

What should I do if I forget a dose?

If you forget to take a dose of Desmopressin Nasal, take it as soon as you remember unless it’s almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you’re unsure about what to do, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Desmopressin Nasal, like any medication, can cause side effects, although not everyone experiences them. Common side effects may include:

  • Nasal Irritation: This can manifest as discomfort, congestion, or mild nosebleeds due to the nasal administration of the medication.
  • Headache: Some individuals may experience headaches while using Desmopressin Nasal.
  • Nausea: Nausea or feelings of queasiness may occur in some users.
  • Stomach Upset: This can include symptoms such as stomach pain, cramping, or diarrhea.
  • Flushing: Some people may experience a sensation of warmth or flushing of the skin.
  • Water Retention: Desmopressin can lead to fluid retention, which may cause swelling, particularly in the hands, feet, or ankles.
  • Hyponatremia: In rare cases, excessive water retention can dilute sodium levels in the blood, leading to a condition called hyponatremia. Symptoms of hyponatremia include confusion, headaches, nausea, and in severe cases, seizures or coma.
  • Hypertension: Desmopressin Nasal may cause increases in blood pressure, particularly in individuals who are already hypertensive or prone to hypertension.
  • Allergic Reactions: Though uncommon, some individuals may experience allergic reactions to Desmopressin Nasal, which can include rash, itching, swelling, or difficulty breathing.

It’s essential to report any side effects to your healthcare provider, especially if they persist, worsen, or if you experience any severe reactions. Your healthcare provider can offer guidance on managing side effects and may adjust your treatment regimen if necessary.

What should I know about storage and disposal of this medication?

When it comes to storage and disposal of Desmopressin Nasal, here are some important points to consider:


  • Store Desmopressin Nasal at room temperature away from light and moisture.
  • Avoid storing it in the bathroom, as moisture and heat can degrade the medication.
  • Keep the medication out of reach of children and pets.


  • Dispose of unused or expired Desmopressin Nasal properly according to local guidelines or instructions provided by your pharmacist.
  • Do not flush medications down the toilet unless instructed to do so. Proper disposal helps prevent environmental contamination.
  • If unsure about how to dispose of the medication, consult your pharmacist or healthcare provider for guidance.

In case of emergency/overdose

  • Contact emergency medical services or your local poison control center immediately.
  • If possible, provide them with information about the medication, dosage, and any symptoms experienced.
  • Follow any instructions provided by emergency responders or healthcare professionals.

What other information should I know?

  • Keep all appointments with your healthcare provider for monitoring and adjustments to your treatment regimen.
  • Inform all healthcare providers involved in your care about your use of Desmopressin Nasal, including dentists and specialists.
  • Carry identification indicating your use of Desmopressin Nasal, especially if you have a medical emergency or need surgery.
  • Avoid consuming excessive fluids while taking Desmopressin Nasal to prevent water intoxication.
  • If you have diabetes insipidus, monitor your fluid intake and output as directed by your healthcare provider to ensure proper hydration and medication effectiveness.

Following these guidelines and staying informed about your medication can help ensure safe and effective use of Desmopressin Nasal. If you have any questions or concerns, don’t hesitate to discuss them with your healthcare provider or pharmacist.

Copyright © 2023