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Dayvigo (Generic Lemborexant)

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Why is this medication prescribed?

Insomnia is treated with lemborexant (difficulty falling asleep or staying asleep). A group of drugs known as hypnotics includes lemborexant. It functions by reducing brain activity so that sleep can occur.

How should this medicine be used?

Lemborexant is available as an oral tablet. It is often used as needed, not more than once per day, just before going to bed. If lemborexant is not taken with food or right after eating, it will function more quickly. Ask your doctor or chemist to explain any instructions on your prescription label that you are unsure about following. As advised, take lemborexant as prescribed.

Immediately following the administration of lemborexant, you’ll likely experience extreme sleepiness, which will likely last for a while. After taking lemborexant, schedule a sleep period of at least seven hours. Lemborexant should not be taken if you won’t be able to fall asleep immediately away and stay asleep for at least 7 hours after taking the drug.

Within seven to ten days of beginning to use lemborexant, you ought to be sleeping soundly. If your sleep issues do not improve during this period, if they worsen at any point while you are receiving therapy, or if you notice any changes in your thinking or behaviour, call your doctor.

Lemborexant could create bad habits. Don’t take the medication in excess of what your doctor has suggested in terms of dosage, frequency, or duration.

When you start receiving lemborexant medication and each time you need a prescription refill, your doctor or chemist will provide you the manufacturer’s patient information leaflet (Medication Guide). If you have any questions, thoroughly read the information, then consult your physician or chemist. The Medication Guide is also available on the Food and Drug Administration (FDA) website or the manufacturer’s website.

Other uses for this medicine

Ask your doctor or chemist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking lemborexant,

  • If you have an allergy to lemborexant, any other drugs, or any of the substances in lemborexant tablets, inform your doctor right away. For a list of the ingredients, consult the Medication Guide or speak with your chemist.
  • Inform your doctor and chemist about any other prescription and over-the-counter drugs, vitamins, and dietary supplements you are now taking or intend to take. Incorporate any of the following: Clarithromycin, chlorzoxazone, efavirenz (Sustiva, in Atripla, in Symfi), bosentan (Tracleer), bupropion (Aplenzin, Forfivo, Wellbutrin), carbamazepine (Carbatrol, Epitol, Tegretol, among others), etravirine (Intelence), fluconazole (Diflucan), itraconazole (Onmel, Sporanox, Tolsura); prescription drugs for pain and anxiety, methadone (Dolophine, Methadose), modafinil (Provigil), ranitidine (Zantac), rifampin (Rifadin, Rimactane, in Rifamate, in Rifater), sedatives, sleeping pills, and tranquillizers; amitriptyline, clomipramine (Anafranil), desipramine (Norpramin), doxepin, imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), and verapamil are examples of tricyclic antidepressants (Calan, Verelan, in Tarka). Your doctor might advise against taking lemborexant, need to adjust the dosage of your medication, or keep a close eye on you for any negative effects. Lemborexant may interact with a variety of other drugs, so be careful to inform your doctor about all the drugs you are taking, even those not on this list.
  • In particular, mention St. John’s wort to your doctor when you use any herbal remedies.
  • In case you have Narcolepsy, let your doctor know (a condition that causes excessive daytime sleepiness). Probably won’t recommend using lemborexant, your doctor will say.
  • Inform your physician if you currently use or have previously used excessive amounts of street drugs, alcohol, or prescription medications. Tell your doctor if you suffer from or have ever suffered from depression, mental illness, suicidal thoughts or attempts, heavy snoring, sleep apnea (a condition in which breathing briefly stops multiple times throughout the night), other breathing issues or lung diseases like asthma, bronchitis, or emphysema, cataplexy (episodes of sudden and transient muscle weakness), or liver disease.
  • Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. Call your doctor if you become pregnant while taking lemborexant.
  • Inform your doctor or dentist that you are taking lemborexant if you are having surgery, including dental surgery.
  • You should be aware that this prescription may make you drowsy, less mentally alert, take longer to react, impair your coordination the day after taking it, produce blurry or double vision, and perhaps increase your risk of falling. If you get out of bed in the middle of the night, take extra precautions to prevent falling. Even if you feel fully awake the day after taking lemborexant, your ability to drive or operate machinery may be compromised. Until you are certain of how lemborexant may impact you, do not operate machinery or drive a car.
  • Avoid drinking alcohol while receiving lemborexant therapy. Lemborexant adverse effects can be exacerbated by alcohol.
  • You should be aware that lemborexant has resulted in significant or even potentially fatal sleep disturbances. Lemborexant users have been known to get out of bed, drive their automobiles, cook and consume food, engage in sex, make phone calls, sleep walk, or engage in other activities while not fully awake. These people couldn’t recall what they had done when they awoke. Lemborexant may cause these side effects whether or not you consume alcohol or are taking other sleep aids. If you’ve ever experienced an unusual pattern of sleep while taking lemborexant, call your doctor straight away.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What side effects can this medication cause?

Lemborexant might have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Drowsiness
  • Tiredness
  • Headache
  • Vivid, strange nightmares or dreams

Certain adverse effects can be very harmful. Call your doctor right away and stop taking lemborexant if you have any of these signs:

  • Temporary inability to speak or move while you fall asleep or wake up (sleep paralysis)
  • Abrupt and transient leg weakness
  • New or worsening anxiety or depression
  • Suicidal, fatal, or self-destructive thoughts, plans, or attempts
  • Beginning of acute muscular wasting
  • Rapid heartbeat

Further negative effects of lemborexant may occur. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Keep it away from excessive heat and moisture at room temperature (not in the bathroom).

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your chemist or the garbage/recycling agency in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose symptoms could include:

  • Drowsiness

What other information should I know?

Keep all of your doctor’s appointments.

No one else should take your medication. Lemborexant is an illegal drug. Only a limited amount of refills are permitted for prescriptions; if you have any questions, speak with your chemist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Dayvigo®
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