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Daypro (Generic Oxaprozin)

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Nonsteroidal anti-inflammatory drugs (NSAIDs) other than aspirin, such oxaprozin, may increase the risk of a heart attack or stroke compared to those who do not take them. These occurrences could be fatal and could occur suddenly. For those who take NSAIDs for an extended period of time, this risk may be larger. If you have recently experienced a heart attack, avoid taking an NSAID like oxaprozin unless your doctor specifically instructs you to. Inform your doctor if you smoke, have high cholesterol, high blood pressure, or diabetes, or if you or anyone in your family has ever suffered from heart disease, a heart attack, or a stroke. If you suffer any of the following symptoms, seek emergency medical attention right away: chest pain, shortness of breath, weakness on one side or area of the body, or slurred speech.

You should avoid taking oxaprozin shortly before or right after having a coronary artery bypass graft (CABG; a form of cardiac surgery).

NSAIDs, including oxaprozin, can result in stomach or intestine ulcers, bleeding, or holes. These issues can arise at any point during therapy, without any prior symptoms, and they have the potential to be fatal. Those who take NSAIDs frequently, are older, or are in poorer health may be at greater risk. or consume significant quantities of alcohol while taking oxaprozin. If you use any of the following medications, let your doctor know: Aspirin, other NSAIDs including ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), and warfarin (Coumadin, Jantoven), which are anticoagulants (sometimes known as “blood thinners”); oral steroids like prednisone (Rayos), methylprednisolone (Medrol), and dexamethasone; citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft) are examples of selective serotonin reuptake inhibitors (SSRIs); or SNRIs (serotonin norepinephrine reuptake inhibitors), which include duloxetine (Cymbalta), desvenlafaxine (Khedezla), and venlafaxine (Effexor XR). Moreover, let your doctor know if you now have or have ever had stomach or intestinal bleeding, ulcers, or any other bleeding diseases. Call your physician and stop taking oxaprozine if you have any of the following symptoms: stomach pain, heartburn, vomiting of a bloody or coffee-ground-like substance, blood in the stool, or dark, tarry stools.

Keep all of your appointments with your physician and the lab. In order to determine how well your body is responding to oxaprozin, your doctor will likely closely monitor your symptoms and run a number of tests. Inform your physician about your feelings so that they can prescribe the ideal dosage of medication to cure your problem with the least chance of negative side effects.

When you start taking oxaprozin and each time you refill your prescription, your doctor or chemist will give you the medication guide provided by the manufacturer. If you have any questions, carefully read the information and ask your doctor or chemist. The Medication Guide is also available on the manufacturer’s website or the Food and Drug Administration (FDA) website.

Why is this medication prescribed?

Oxaprozin is used to treat osteoarthritis (arthritis brought on by a breakdown of the lining of the joints) and rheumatoid arthritis pain, soreness, edoema, and stiffness (arthritis caused by swelling of the lining of the joints). Oxaprozin is also used to treat juvenile rheumatoid arthritis in children 6 years of age and older, which causes pain, tenderness, swelling, and stiffness. Oxaprozin belongs to the group of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs). It functions by halting the body’s production of a chemical responsible for inflammation, fever, and discomfort.

How should this medicine be used?

Oxaprozin is available as a tablet to be swallowed. Typically, it is taken once or twice a day. Every day, take oxaprozine around the specified time(s). Ask your doctor or chemist to explain any instructions on your prescription label that you are unsure about following. Opt for oxaprozin dosage as prescribed. Never take it in larger or less amounts or more frequently than directed by your doctor.

Other uses for this medicine

Ask your doctor or chemist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking oxaprozin,

  • Inform your doctor and chemist if you have any drug allergies, including those to oxaprozin, aspirin, other NSAIDs including ibuprofen (Advil, Motrin), naproxen (Aleve), or any of the inactive components in oxaprozin tablets. Get a list of the inactive substances from your chemist.
  • Inform your doctor and chemist about any prescription and over-the-counter drugs, vitamins, herbal items, and nutritional supplements you are now taking or intend to take. Make careful to bring up any of the following, along with any of the medications indicated in the IMPORTANT WARNING section: the ACE inhibitors benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril (Monopril), lisinopril (in Zestoretic), moexipril (Univasc), perindopril (Aceon, in Prestalia), quinapril (Accupril, in Quinaretic); angiotensin receptor blockers (ARBs) include eprosartan (Teveten), candesartan (Atacand), azilsartan (Edarbi, in Edarbyclor), and irbesartan (Avapro, in Avalide), telmisartan (Micardis, in Micardis HCT, in Twynsta), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor), and valsartan (in Exforge HCT); beta blockers such nadolol (Corgard, in Corzide), propranolol (Hemangeol, Inderal, Innopran), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, in Dutoprol), and atenolol (Tenormin, in Tenoretic); methotrexate, glyburide (Glynase, Micronase), lithium (Lithobid), and diuretics (‘water pills’) (Otrexup, Rasuvo, Trexall). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your doctor if you have or have ever had asthma, especially if you also have heart failure, swollen hands, feet, ankles, or lower legs, renal disease, or liver illness.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. If oxaprozin is consumed beyond 20 weeks of pregnancy, it may harm the foetus and complicate delivery. Unless as directed by your physician, avoid using oxaprozin during or after the first 20 weeks of pregnancy. Call your doctor if you become pregnant while taking oxaprozin.
  • If you are 65 years of age or older, discuss the advantages and disadvantages of taking oxaprozin with your doctor. Because higher dosages used frequently may not be more effective and are more likely to have major side effects, older persons should only take lower doses of oxaprozin for brief periods of time.
  • Inform your doctor or dentist that you are taking oxaprozin if you are having surgery, including dental surgery.
  • Have a plan to limit your time spent in the sun and to use sunscreen, sunglasses, and protective clothes. Your skin could become sun-sensitive if you take oxaprozin.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

Oxaprozin could have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Diarrhea
  • Constipation
  • Vomiting
  • Gas or bloating
  • Drowsiness
  • Difficulty sleeping
  • Confusion
  • Depression
  • Dizziness
  • Headache
  • Ringing in the ears

Some adverse effects may be severe. Call your doctor right away if you notice any of the symptoms listed below or those that are stated in the IMPORTANT WARNING section. Until you speak with your doctor, stop taking oxaprozin:

  • Unexplained weight gain
  • Shortness of breath or difficulty breathing
  • Swelling in the abdomen, ankles, feet, or legs
  • Fever
  • Blisters
  • Rash
  • Itching
  • Hives
  • Swelling of the eyes, face, lips, tongue, throat, or hands
  • Hoarseness
  • Difficulty breathing or swallowing
  • Yellowing of the skin or eyes
  • Lack of energy
  • Excessive tiredness
  • Upset stomach
  • Loss of appetite
  • Pain in the upper right part of the stomach
  • Flu-like symptoms
  • Pale skin
  • Fast heartbeat
  • Cloudy, discolored, or bloody urine
  • Back pain
  • Difficult or painful urination

Further negative effects of oxyprozin are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Keep it away from excessive heat and moisture at room temperature (not in the bathroom).

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your chemist or the garbage/recycling agency in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Symptoms of overdose may include the following:

  • Not enough energy
  • Drowsiness
  • Uneasy stomach
  • Vomiting
  • Abdominal pain
  • Tarry, dark, or bloody stools
  • Vomiting something that looks like coffee grounds or is bloody
  • Having trouble breathing
  • Seizures
  • Coma (loss of consciousness for a period of time)

What other information should I know?

Inform the lab staff and your doctor that you are taking oxaprozin prior to any laboratory test.

No one else should take your medication. Any queries you may have regarding prescription refills should be directed to your chemist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Daypro®
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