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Daunorubicin

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WARNING

Daunorubicin injection must be administered in a hospital or other healthcare institution under the guidance of a physician with training in administering chemotherapy drugs for cancer.

Any time throughout your therapy or months to years after it has stopped, daunorubicin has the potential to cause significant or life-threatening heart issues. Before and during your treatment, your doctor will request tests to determine whether your heart is healthy enough for you to safely receive daunorubicin. These tests could involve an electrocardiogram (ECG), which records the electrical activity of the heart, and an echocardiogram, which gauges the heart’s capacity to pump blood using sound waves. If tests reveal that your heart’s capacity to pump blood has deteriorated, your doctor could advise against taking this drug. Inform your doctor if you have or have previously had a cardiac condition, as well as any radiation (x-ray) therapy for the chest. If you take or have ever taken certain cancer chemotherapy drugs such mitoxantrone (Novantrone), cyclophosphamide (Cytoxan), doxorubicin (Doxil), epirubicin (Ellence), idarubicin (Idamycin), or trastuzumab, let your doctor and chemist know (Herceptin). Make a quick call to your doctor if you encounter any of the following signs: Shortness of breath, breathing difficulties, swollen hands, feet, ankles, or lower legs, or a rapid, erratic, or pounding heartbeat

Your bone marrow’s ability to produce blood cells may be severely affected by daunorubicin. This could result in specific symptoms and raise your risk of getting a major infection or bleeding. Call your doctor right away if you have any of the following symptoms: Unusual bleeding or bruises; fever, sore throat, persistent cough, and congestion, among other infection-related symptoms.

If you have kidney or liver problems now or in the past, let your doctor know. If you have liver or kidney illness, your doctor might need to change your dosage.

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to daunorubicin, your doctor will prescribe a number of tests.

Why is this medication prescribed?

To treat a specific form of acute myeloid leukaemia, daunorubicin is combined with other chemotherapy medicines (AML; a type of cancer of the white blood cells). A specific form of acute lymphocytic leukaemia is also treated with dunorubicin in combination with other chemotherapy medicines (ALL; a type of cancer of the white blood cells). The drug daunorubicin belongs to the anthracycline drug class. It functions by reducing or halting the development of cancer cells within your body.

How should this medicine be used?

In a hospital setting, a doctor or nurse will administer daunorubicin intravenously (into a vein) together with other chemotherapy drugs. Daunorubicin is available as a liquid solution or as a powder that must be combined with liquid. Daunorubicin is typically injected once daily on specific days during your treatment period when it is used to treat AML. Daunorubicin is typically injected once per week while treating ALL. The sort of drugs you are taking, how well your body reacts to them, and the type of cancer you have will all affect how long your treatment will last.

For a copy of the manufacturer’s information for the patient, ask your chemist or doctor.

Other uses for this medicine

Ask your doctor or chemist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving daunorubicin injection,

  • If you have an allergy to daunorubicin, any other drugs, or any of the ingredients in daunorubicin injection, inform your doctor and pharmacist right away. ingredients.
  • Inform your doctor and chemist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Azithromycin (Imuran), cyclosporine (Neoral, Sandimmune), methotrexate (Rheumatrex, Trexall), sirolimus (Rapamune), tacrolimus, and any of the following medications should be mentioned (Prograf). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects. Daunorubicin may also interfere with other drugs, so be sure to let your doctor know about all the ones you’re taking, even if they’re not on this list.
  • Inform your doctor of any medical conditions you now have or have ever had.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Pregnancy should not occur while you are getting an injection of daunorubicin. Call your doctor if you conceive while taking daunorubicin. The foetus could suffer from daunorubicin.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What side effects can this medication cause?

Side effects from daunorubicin are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Nausea
  • Vomiting
  • Mouth- and throat-related sores
  • Diarrhea
  • Abdominal pain
  • Hair fall
  • Red faeces

Certain adverse effects can be very harmful. Call your doctor right away if you have any of these signs or any of those in the IMPORTANT CAUTION section:

  • Redness, discomfort, swelling, or burning at the injection site
  • Rash
  • Hives
  • Itching
  • Breathing or swallowing challenges

Daunorubicin may make you more likely to get other malignancies. The dangers of using this drug should be discussed with your doctor.

Further negative effects of daunorubicin are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Cerubidine®
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