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Dasiglucagon Injection

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Why is this medication prescribed?

Severe hypoglycemia (extremely low blood sugar) in diabetic adults and children 6 years of age and older is treated with dasiglucagon injection in addition to emergency medical care. A group of drugs known as glucagon receptor agonists includes dasiglucagon injection. It functions by inducing the liver to release sugar that has been stored into the circulation.

How should this medicine be used?

Dasiglucagon injection is available as a liquid solution in prefilled syringes and an auto-injector tool for subcutaneous injection (just under the skin). At the first indication of severe hypoglycemia, it is often injected as necessary. The patient should be placed onto their side after the injection to avoid choking if they vomit. Take dasiglucagon injection precisely as instructed; do not administer it more frequently or in larger or smaller doses than recommended by your doctor.

Ask your doctor or chemist to demonstrate how to use and make dasiglucagon injection for you, your family, or any caretakers who may be injecting the medication. Read the included patient information before a friend or family member administers dasiglucagon injection for the first time. The instructions for using the injectable device are included in this material. If you or your carers have any questions regarding how to inject this drug, be sure to ask your chemist or doctor.

An unconscious person with hypoglycemia (low blood sugar) who has received a dasiglucagon injection often awakens in 15 minutes. After administering the dasiglucagon, seek immediate medical attention by calling a doctor. Give a second dosage of dasiglucagon if the patient doesn’t wake up within 15 minutes of the injection. As soon as the person awakens and is able to swallow, give them a fast-acting source of sugar (like a standard soft drink or fruit juice) and then a long-acting source of sugar (such crackers, cheese, or a meat sandwich).

When injecting dasiglucagon, always examine the solution. It should be free of particulates, clean, and colourless. Dasiglucagon injection should not be used if it is foggy, includes particles, or has passed its expiration date. For disposal instructions on the puncture-resistant container, consult your doctor or chemist.

Dasiglucagon injections can be administered with an autoinjector or prefilled syringe in the upper arm, thigh, stomach, or buttocks. Do not inject through clothing; instead, roll back any coverings to reveal bare skin. Never administer dasiglucagon with an autoinjector or prefilled syringe into a vein or muscle.

All patients should have a family member who is familiar with dasiglucagon administration and low blood sugar symptoms. If you frequently experience low blood sugar, always carry dasiglucagon injectable with you. Several of the symptoms and indicators of low blood sugar should be recognisable by you and a family member or acquaintance (i.e., shakiness, dizziness or lightheadedness, sweating, confusion, nervousness or irritability, sudden changes in behaviour or mood, headache, numbness or tingling around the mouth, weakness, pale skin, sudden hunger, clumsy or jerky movements). Before dasiglucagon needs to be administered, try to eat or drink something sweet, like hard candy or fruit juice.

For a copy of the manufacturer’s information for the patient, ask your chemist or doctor.

Other uses for this medicine

Ask your doctor or chemist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving dasiglucagon injection,

  • If you have any type of allergy, including to latex, any medication, dasiglucagon, other drugs, or any of the chemicals in dasiglucagon injection, notify your doctor right away. Get an ingredient list from your chemist.
  • Inform your doctor and chemist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Beta blockers such atenolol (Tenormin), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal, Innopran), as well as indomethacin (Indocin) and warfarin, should all be mentioned (Coumadin, Jantoven). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your physician if you have an insulinoma or pheochromocytoma (a tumour on a tiny gland close to the kidneys) (pancreatic tumors). Most likely, your doctor will advise against using dasiglucagon injection.
  • Inform your doctor if you have ever experienced heart disease, malnutrition, or issues with your adrenal glands. Moreover, let your doctor know if you experience persistently low blood sugar.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

The usual dosage for this drug is as needed.

What side effects can this medication cause?

Side effects from dasiglucagon injection are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Nausea
  • Vomiting
  • Headache
  • Diarrhea
  • Painful injection location
  • Rapid heart rate

Certain adverse effects can be very harmful. Call your doctor right away if any of these symptoms occur to you:

  • Rash
  • Having trouble breathing

Further negative effects from dasiglucagon injection are possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed, out of the light, and away from minors in the supplied case that it arrived in. Do not freeze; instead, keep it in the refrigerator away from the cooling element. It can also be stored at room temperature for up to 12 months; however, after being maintained at room temperature, do not put it back in the refrigerator. In the case, note the date the injection was taken out of the refrigerator. Any medication that has been harmed, expired, or kept at room temperature for more than a year should be disposed of, and a replacement should be on hand.

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your chemist or the garbage/recycling agency in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose symptoms could include:

  • Nausea
  • Vomiting
  • Constipation
  • Quick or frantic heartbeat

What other information should I know?

Keep all of your appointments with your physician and the lab.

Do not share your medication with anybody else. Get a new dasiglucagon injection right soon if your old one is used. Any queries you may have regarding prescription refills should be directed to your chemist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Zegalogue®
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