Why is this medication prescribed?

Dasatinib is a medication primarily prescribed to treat certain types of cancer. It belongs to a class of drugs called tyrosine kinase inhibitors (TKIs). Dasatinib is commonly used in the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). It works by inhibiting the activity of certain proteins (tyrosine kinases) that are involved in the growth and spread of cancer cells. By blocking these proteins, dasatinib helps to slow down or stop the progression of the cancer, improving the patient’s prognosis and quality of life.

How should this medicine be used?

Dasatinib is typically taken orally, usually once daily. It’s important to follow the specific instructions provided by your healthcare provider. Generally, dasatinib is taken with or without food, but it’s crucial to take it consistently the same way every day.

Here are some general guidelines for taking dasatinib:

• Follow your doctor’s instructions: Always take dasatinib exactly as prescribed by your healthcare provider. Do not alter the dosage or frequency without consulting your doctor first.
• Take it at the same time each day: Try to take dasatinib at the same time every day to maintain a consistent level of the medication in your bloodstream.
• Swallow the tablets whole: Do not crush, chew, or break the tablets before swallowing. Swallow them whole with a glass of water.
• Do not skip doses: It’s important to take dasatinib regularly as prescribed, even if you start feeling better. Skipping doses or stopping treatment prematurely could allow the cancer to come back or worsen.
• If you miss a dose: If you forget to take your dose of dasatinib, take it as soon as you remember, unless it’s almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
• Storage: Store dasatinib tablets at room temperature away from moisture and heat. Keep the medication in its original container with the lid tightly closed.

Always consult your healthcare provider if you have any questions or concerns about how to take dasatinib or if you experience any side effects while taking the medication.

Other uses for this medicine

Dasatinib is primarily used for the treatment of certain types of cancer, particularly chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). However, researchers have explored its potential in other conditions as well. Some studies have investigated dasatinib’s efficacy in treating certain solid tumors and other hematological malignancies, but these uses are still investigational and not yet established as standard treatments.

What special precautions should I follow?

As for special precautions to follow when taking dasatinib:

• Regular monitoring: Your doctor will likely monitor your blood counts and liver function regularly while you’re taking dasatinib to ensure it’s working effectively and to watch for any potential side effects.
• Drug interactions: Inform your healthcare provider about all medications, supplements, and herbal products you’re taking, as dasatinib can interact with other drugs. Certain medications, including those metabolized by the CYP3A4 enzyme system, may interact with dasatinib and affect its efficacy or increase the risk of side effects.
• Pregnancy and breastfeeding: Dasatinib may cause harm to a developing fetus, so it’s important to use effective contraception during treatment if you’re of childbearing potential. Additionally, avoid breastfeeding while taking dasatinib, as it may pass into breast milk and harm the nursing infant.
• Liver and kidney function: Inform your doctor if you have a history of liver or kidney problems, as dasatinib may require dosage adjustments or special monitoring in these cases.
• Cardiac function: Dasatinib has been associated with cardiac side effects in some patients, including heart rhythm abnormalities and heart failure. If you have a history of heart disease or any cardiac risk factors, your doctor may monitor your heart function closely while you’re taking dasatinib.
• Bleeding risk: Dasatinib may increase the risk of bleeding, so it’s important to report any signs of bleeding or unusual bruising to your doctor.
• Skin reactions: Some patients may experience skin reactions such as rash or dry skin while taking dasatinib. Inform your doctor if you experience any skin changes or irritations.
• Bone marrow suppression: Dasatinib can cause bone marrow suppression, leading to low blood cell counts (anemia, neutropenia, thrombocytopenia). Your doctor will monitor your blood counts regularly and may adjust your dosage or provide supportive care if needed.

Always follow your doctor’s advice and recommendations regarding dasatinib treatment, and promptly report any side effects or concerns you may have during your course of treatment.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Dasatinib. However, it’s essential to maintain a healthy, balanced diet to support your overall health and well-being during cancer treatment. Make sure to stay hydrated by drinking plenty of fluids, and consider consulting a dietitian for personalized dietary advice if needed.

What should I do if I forget a dose?

If you forget to take your dose of Dasatinib, take it as soon as you remember, unless it’s almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you’re unsure about what to do, or if you have any concerns, consult your healthcare provider for guidance.

What side effects can this medication cause?

Dasatinib, like many medications, can cause side effects. These can vary in severity from person to person. Some common side effects of dasatinib include:

• Nausea and vomiting: Feeling sick to your stomach and vomiting are common side effects of dasatinib.
• Diarrhea: Some people may experience diarrhea while taking dasatinib. This side effect can range from mild to severe.
• Fatigue: Feeling tired or fatigued is a common side effect of many cancer medications, including dasatinib.
• Headache: Headaches are a possible side effect of dasatinib treatment.
• Skin rash: Some people may develop a rash or other skin changes while taking dasatinib.
• Fluid retention: Dasatinib can sometimes cause fluid retention, leading to swelling in the hands, feet, or ankles.
• Muscle and joint pain: Some people may experience muscle or joint pain while taking dasatinib.
• Low blood cell counts: Dasatinib can suppress bone marrow function, leading to low levels of red blood cells, white blood cells, and platelets. This can increase the risk of anemia, infection, and bleeding.
• Cardiac effects: Dasatinib may affect heart function in some people, leading to conditions like heart failure or irregular heart rhythms.
• Pulmonary hypertension: Rarely, dasatinib has been associated with an increased risk of pulmonary hypertension, a serious condition affecting the blood vessels in the lungs.

It’s important to report any side effects you experience while taking dasatinib to your healthcare provider. They can provide guidance on managing side effects and may adjust your treatment plan if needed. Additionally, some side effects may require immediate medical attention, so it’s essential to seek help if you experience severe or concerning symptoms.

What should I know about storage and disposal of this medication?

Storage and disposal of Dasatinib:

• Storage: Store Dasatinib tablets at room temperature, away from moisture and heat. Keep the medication in its original container with the lid tightly closed. Do not remove tablets from their original packaging until you are ready to take them.
• Disposal: Dispose of unused or expired Dasatinib tablets properly according to local regulations or guidelines. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Instead, consult your pharmacist or local waste disposal facility for guidance on safe disposal methods.

In case of emergency/overdose

If you suspect an overdose or experience severe side effects after taking Dasatinib, seek emergency medical attention or contact your local poison control center immediately. Symptoms of overdose may include severe nausea, vomiting, diarrhea, or unusual bleeding or bruising.

What other information should I know?

• Follow your healthcare provider’s instructions carefully when taking dasatinib. Do not change your dose or stop taking the medication without consulting your doctor.
• Inform your doctor about all other medications, supplements, and herbal products you are taking, as dasatinib may interact with certain drugs.
• Attend all scheduled appointments with your healthcare provider for monitoring of your condition and response to treatment.
• Report any side effects or concerns to your doctor promptly.
• Dasatinib may lower your body’s ability to fight infections. Avoid contact with people who have contagious illnesses, and practice good hygiene to reduce the risk of infection.
• Avoid activities that may increase the risk of injury or bleeding while taking dasatinib, as it may affect your blood clotting ability.
• It’s important to use effective contraception during treatment with dasatinib, as it may harm an unborn baby. Discuss family planning with your doctor if applicable.

Always consult your healthcare provider or pharmacist for specific guidance on the storage, disposal, and emergency procedures related to dasatinib, as individual circumstances may vary.