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Darzalex (Generic Daratumumab Injection)

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Why is this medication prescribed?

Multiple myeloma is a kind of bone marrow cancer that can be treated with a daratumumab injection. It is used to treat newly diagnosed patients as well as those who have not improved with treatment or who have recovered after receiving treatment with other drugs but the condition has reappeared. Daratumumab is a member of the monoclonal antibody drug class. It functions by supporting the body’s efforts to impede or halt the growth of cancer cells.

How should this medicine be used?

In a medical context, a doctor or nurse will administer daratumumab intravenously (into a vein) using a liquid (solution). Depending on other medications you may be taking and how your body reacts to this medication, your doctor will determine how frequently you should take daratumumab.

Both during and after the infusion, a doctor or nurse will keep a close eye on you to make sure you are not having a severe reaction to the medication. Before to your infusion as well as the first and second days following your medication administration, you will be given additional medications to assist prevent and treat reactions to daratumumab. If you experience any of the following symptoms, contact your doctor or nurse right away: coughing, wheezing, throat tightness and irritation, itchy, runny, or stuffy nose, headache, itching, nausea, vomiting, fever, chills, rash, or hives; dizziness, lightheadedness; breathing difficulties; chest discomfort; or shortness of breath.

Daratumumab dosage adjustments or temporary or permanent therapy termination are both options available to your doctor. The effectiveness of the drug and any negative side effects you encounter will determine this. Throughout your daratumumab therapy, be careful to let your doctor know how you are feeling.

For a copy of the manufacturer’s information for the patient, ask your chemist or doctor.

Other uses for this medicine

Ask your doctor or chemist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving daratumumab injection,

  • If you have any allergies, including to any inactive chemicals in daratumumab injection, tell your doctor and chemist right away. For a list of the chemicals, see your chemist or the patient information provided by the manufacturer.
  • Inform your doctor and chemist about any additional prescription and over-the-counter medications, vitamins, herbal items, nutritional supplements, and other drugs you are now taking or intend to take. Your doctor might need to adjust your medication doses or keep a close eye out for any negative side effects.
  • Inform your physician if you have shingles now or ever have, are receiving blood transfusions, or are pregnant (a painful rash that occurs after infection with herpes zoster or chickenpox), respiratory issues, hepatitis B (a liver-infecting virus that can cause serious liver damage), or a lung condition such chronic obstructive pulmonary disease (COPD); a collection of respiratory conditions that includes emphysema and chronic bronchitis).
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Use birth control to avoid getting pregnant while receiving daratumumab medication and for at least three months after your last dosage. Discuss the various birth control methods that will work for you with your doctor. Call your doctor if you fall pregnant while receiving a daratumumab injection.
  • Inform the surgeon or dentist that you are receiving a daratumumab injection if you are undergoing surgery, including dental surgery.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

Call your doctor right away if you are late for a daratumumab appointment.

What side effects can this medication cause?

The injection of daratumumab may have adverse effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Tiredness
  • Constipation
  • Diarrhea
  • Joint or back ache
  • Discomfort in your chest, arms, or legs
  • Reduction in hunger
  • Headache
  • Hands, ankles, or feet swelling
  • Hands or feet tingling, burning, or pain
  • Muscles cramping
  • Having trouble falling or staying asleep

Certain adverse effects can be very harmful. Call your doctor right away or seek emergency medical attention if you suffer any of these symptoms or any of the ones detailed in the HOW section.

  • Bleeding or bruising
  • Fever
  • Extreme fatigue
  • Epidermis or eye yellowing

Further negative effects from daratumumab injection are possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What other information should I know?

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to the daratumumab injection, your doctor will order specific lab tests both before and after your therapy.

Inform your doctor and the lab staff that you are receiving or have just received a daratumumab injection prior to any laboratory test. Daratumumab may have an impact on the outcomes of specific laboratory tests.

Blood matching test results can be impacted by daratumumab for up to 6 months following your last dose. Inform your physician and the laboratory staff that you are receiving or have just received a daratumumab injection prior to receiving a blood transfusion. Before you begin treatment with daratumumab, your doctor will do blood tests to match your blood type.

Ask your chemist any inquiries you may have regarding the injection of daratumumab.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Darzalex®
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