Why is this medication prescribed?

Daratumumab and hyaluronidase-fihj Injection is prescribed for the treatment of multiple myeloma, a type of cancer that affects plasma cells in the bone marrow. Daratumumab, a monoclonal antibody, works by targeting a protein called CD38 on the surface of myeloma cells, which helps the body’s immune system to recognize and destroy the cancerous cells. Hyaluronidase-fihj is an enzyme that helps to deliver daratumumab by increasing its absorption and distribution in the body.

How should this medicine be used?

Daratumumab and hyaluronidase-fihj Injection is typically administered under the skin (subcutaneously) by a healthcare professional. The specific dosage and administration schedule will be determined by your healthcare provider based on factors such as your weight, overall health, and response to treatment. However, here is a general overview of how the injection is commonly used:

• Preparation: The healthcare provider will prepare the injection by reconstituting daratumumab and hyaluronidase-fihj according to the manufacturer’s instructions.
• Administration: The injection is usually given in the abdomen (around the navel) or the upper thigh. The exact injection site may vary depending on your healthcare provider’s recommendation. The healthcare provider will clean the injection site with an antiseptic solution before administering the injection.
• Injection Technique: The healthcare provider will use a syringe or an injection pen to administer the medication subcutaneously. They will insert the needle into the skin at a 45 to 90-degree angle, depending on the injection device used and the amount of subcutaneous tissue.
• Monitoring: After the injection, the healthcare provider will monitor you for any immediate reactions or side effects. They may also provide instructions for monitoring yourself at home for any delayed reactions or side effects.
• Follow-up: You will likely require multiple injections over a specified treatment period. Your healthcare provider will determine the frequency and duration of treatment based on your individual response and the progression of your condition.

It’s essential to follow your healthcare provider’s instructions precisely regarding the dosage, administration technique, and schedule of Daratumumab and hyaluronidase-fihj Injection. Additionally, be sure to report any side effects or concerns to your healthcare provider promptly.

Other uses for this medicine

Daratumumab and hyaluronidase-fihj Injection is primarily used for the treatment of multiple myeloma. However, it may also be used for other off-label purposes, as determined by your healthcare provider. Off-label uses refer to the use of a medication for a purpose other than what it is officially approved for by regulatory agencies. Some potential off-label uses of Daratumumab and hyaluronidase-fihj Injection may include certain types of lymphoma or leukemia, as well as other plasma cell disorders.

What special precautions should I follow?

As with any medication, it’s important to take special precautions when using Daratumumab and hyaluronidase-fihj Injection. Here are some general precautions to keep in mind:

• Allergic Reactions: Inform your healthcare provider about any known allergies or hypersensitivity reactions you may have, especially to daratumumab or hyaluronidase-fihj. Serious allergic reactions to medications can occur, so it’s essential to be vigilant for signs such as difficulty breathing, swelling of the face or throat, and rash.
• Infections: Daratumumab can increase the risk of infections, including respiratory tract infections and urinary tract infections. It’s important to practice good hygiene and avoid close contact with individuals who are sick. Inform your healthcare provider if you develop any signs of infection, such as fever, chills, or persistent cough.
• Infusion Reactions: While Daratumumab and hyaluronidase-fihj Injection is typically administered subcutaneously, infusion reactions may still occur. These reactions can include fever, chills, nausea, vomiting, and allergic reactions. Your healthcare provider will monitor you closely during and after each injection to manage any potential reactions.
• Pregnancy and Breastfeeding: It’s essential to discuss the risks and benefits of Daratumumab and hyaluronidase-fihj Injection if you are pregnant, planning to become pregnant, or breastfeeding. The potential effects on the fetus or nursing infant should be carefully considered.
• Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with Daratumumab and hyaluronidase-fihj Injection. Certain medications may increase or decrease the effectiveness of Daratumumab, or they may increase the risk of side effects.
• Monitoring: Your healthcare provider will regularly monitor your blood counts, kidney function, and other relevant parameters to assess the effectiveness and safety of Daratumumab and hyaluronidase-fihj Injection.

Always follow your healthcare provider’s instructions and guidelines for using Daratumumab and hyaluronidase-fihj Injection, and do not hesitate to ask any questions or express any concerns you may have about the treatment.

What special dietary instructions should I follow?

Regarding dietary instructions, there are no specific dietary restrictions associated with Daratumumab and hyaluronidase-fihj Injection. However, maintaining a healthy and balanced diet is important for overall health and may support your body’s ability to tolerate and respond to treatment.

What should I do if I forget a dose?

If you forget a dose of Daratumumab and hyaluronidase-fihj Injection, contact your healthcare provider for guidance. They can advise you on whether it’s necessary to administer the missed dose or adjust your treatment schedule. It’s essential not to double up on doses unless instructed to do so by your healthcare provider. Consistency in treatment is important for achieving optimal results.

What side effects can this medication cause?

Daratumumab and hyaluronidase-fihj Injection, like any medication, can cause side effects, although not everyone experiences them. Some common side effects of this medication may include:

• Infusion Reactions: Even though Daratumumab and hyaluronidase-fihj Injection is usually administered subcutaneously, infusion reactions may still occur. These reactions can include fever, chills, nausea, vomiting, headache, dizziness, itching, rash, and low blood pressure. Infusion reactions are typically managed by adjusting the infusion rate or administering medications to alleviate symptoms.
• Infections: Daratumumab treatment may increase the risk of infections, such as respiratory tract infections, urinary tract infections, and upper respiratory tract infections. Symptoms of infection may include fever, chills, cough, sore throat, and difficulty breathing. Promptly inform your healthcare provider if you experience any signs of infection.
• Fatigue: Feeling tired or fatigued is a common side effect of Daratumumab and hyaluronidase-fihj Injection. It’s essential to rest when needed and to pace yourself during daily activities.
• Nausea and Vomiting: Some individuals may experience nausea or vomiting as a side effect of this medication. These symptoms can often be managed with anti-nausea medications or dietary changes.
• Diarrhea: Diarrhea may occur as a side effect of Daratumumab and hyaluronidase-fihj Injection. It’s important to stay hydrated and inform your healthcare provider if diarrhea persists or is severe.
• Low Blood Cell Counts: Daratumumab can cause decreases in certain blood cell counts, including white blood cells, red blood cells, and platelets. This can increase the risk of infections, anemia, and bleeding. Regular blood tests will be conducted to monitor your blood cell counts during treatment.
• Allergic Reactions: Serious allergic reactions to Daratumumab and hyaluronidase-fihj Injection are rare but possible. Symptoms may include difficulty breathing, swelling of the face or throat, itching, or rash. Seek immediate medical attention if you experience any signs of an allergic reaction.

These are not all the possible side effects of Daratumumab and hyaluronidase-fihj Injection. It’s essential to discuss any concerns or potential side effects with your healthcare provider before starting treatment. They can provide personalized guidance and support throughout your treatment journey.

What should I know about storage and disposal of this medication?

Storage and disposal of Daratumumab and hyaluronidase-fihj Injection:

Storage:

• Daratumumab and hyaluronidase-fihj Injection should be stored in the refrigerator at a temperature between 2°C to 8°C (36°F to 46°F).
• Do not freeze the medication. If frozen, thaw it in the refrigerator before use.
• Protect the medication from light.
• Keep Daratumumab and hyaluronidase-fihj Injection in its original packaging until ready to use.
• Do not use the medication if it has been stored improperly or if the expiration date has passed.

Disposal:

• Dispose of used syringes, needles, and any unused medication according to local regulations.
• Do not dispose of Daratumumab and hyaluronidase-fihj Injection in household trash unless instructed to do so.
• Consult your healthcare provider or pharmacist for guidance on proper disposal methods.

In case of emergency/overdose

• In case of an emergency or suspected overdose, seek immediate medical attention or contact a poison control center.
• Symptoms of overdose may include severe infusion reactions, such as difficulty breathing, severe allergic reactions, or other severe adverse effects.

What other information should I know?

• Keep all appointments for injections and follow-up visits as directed by your healthcare provider.
• Inform all healthcare providers involved in your care that you are receiving Daratumumab and hyaluronidase-fihj Injection.
• Do not share needles, syringes, or medication with others.
• Notify your healthcare provider if you experience any new or worsening symptoms, side effects, or changes in your health during treatment.
• It’s essential to understand the risks and benefits of Daratumumab and hyaluronidase-fihj Injection and to discuss any concerns with your healthcare provider.

Always follow your healthcare provider’s instructions and guidelines regarding the storage, disposal, emergencies, and other aspects of Daratumumab and hyaluronidase-fihj Injection. If you have any questions or need further information, don’t hesitate to ask your healthcare provider or pharmacist for assistance.