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Daratumumab and hyaluronidase-fihj Injection

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Why is this medication prescribed?

Daratumumab and hyaluronidase-fihj injection is used to treat multiple myeloma (a type of bone marrow cancer) in patients who have recently been diagnosed as well as those who have not responded to treatment or who have responded to treatment with other drugs but the condition has returned. It may be used alone or in combination with other drugs or treatments. Another use for daratumumab with hyaluronidase-fihj injection is the treatment of newly diagnosed people with a specific type of amyloidosis (a condition in which aberrant proteins accumulate in body tissues and organs). Daratumumab is a member of the monoclonal antibody drug class. It functions by supporting the body’s efforts to impede or halt the growth of cancer cells. An endoglycosidase is haluronidase-fihj. Daratumumab should stay in the body for a longer period of time to have a stronger impact.

How should this medicine be used?

Injections of daratumumab and hyaluronidase-fihj are administered as a solution (liquid) that must be injected subcutaneously (near the skin) into the stomach over the course of three to five minutes. Depending on your ailment and how well your body responds to treatment, the interval between injections and the total length of your therapy will vary.

When you are taking the drug and subsequently, a doctor or nurse will keep a close eye on you to make sure you are not having a dangerous reaction to the medication. Before and after you receive your medication, other medications will be administered to assist prevent and treat reactions to daratumumab and hyaluronidase-fihj. If you experience any of the following symptoms, call your doctor or nurse right away: breathing problems or shortness of breath; chest pain; wheezing; tightness and irritation in the throat; cough; runny or stuffy nose; headache; itching; nausea; vomiting; fever; chills; rash; hives; eye pain; blurred vision; dizziness; or lightheadedness.

Your doctor may halt your treatment indefinitely or temporarily. The effectiveness of the drug and any negative side effects you encounter will determine this. Throughout your hyaluronidase-fihj and daratumumab treatment, be careful to let your doctor know how you are feeling. For a copy of the manufacturer’s information for the patient, ask your chemist or doctor.

For a copy of the manufacturer’s information for the patient, ask your chemist or doctor.

Other uses for this medicine

Ask your doctor or chemist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving daratumumab and hyaluronidase-fihj injection,

  • If you have an allergy to daratumumab, hyaluronidase-fihj, any other medications, or any of the chemicals in daratumumab and hyaluronidase-fihj injection, let your doctor and chemist know right away. Get a list of the ingredients from your chemist.
  • Inform your doctor and chemist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your physician if you have or have ever had breathing difficulties, shingles (a painful rash that develops after infection with herpes zoster or chickenpox), hepatitis B, which affects the liver and may cause severe liver damage. If you have heart failure or cardiac disease and are receiving treatment for amyloidosis, let your doctor know.
  • Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. During the course of your therapy with daratumumab and hyaluronidase-fihj, as well as for at least three months after your last dose, you should use birth control to avoid getting pregnant. Discuss the various birth control methods that will work for you with your doctor. Call your doctor if you get pregnant while receiving hyaluronidase-fihj and daratumumab.
  • Describe to your doctor if you are nursing a baby. While receiving daratumumab and hyaluronidase-fihj injection, you shouldn’t breastfeed.
  • Inform the surgeon or dentist that you are receiving daratumumab and hyaluronidase-fihj injections if you are having surgery, including dental surgery.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What side effects can this medication cause?

Hyaluronidase-fihj injection with daratumumab may have adverse effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Constipation
  • Diarrhea
  • Vomiting
  • Nausea
  • Abdominal pain
  • Reduced appetite
  • Fatigue
  • Having trouble falling or staying asleep
  • Hands or feet tingling, burning, or pain
  • Hands, ankles, or feet swelling
  • Back or joint ache
  • Muscles cramping
  • Headache
  • Skin irritation, bruising, swelling, or redness at the injection site

Some adverse effects may be severe. Call your doctor right away or seek emergency medical care if you encounter any of these signs or any of the ones detailed in the HOW section:

  • Indications of infection, such as a fever, cough, or sore throat
  • Significant bruising or bleeding
  • Pale skin, exhaustion, or breathlessness
  • Dark urine, yellow urine, or right upper stomach pain or discomfort
  • Shortness of breath, racing or irregular heartbeat, feeling faint, swelling legs, and chest pain (especially if you are being treated for amyloidosis)

Further side effects could be brought on by hyaluronidase-fihj injection and daratumumab. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What other information should I know?

Keep all of your appointments with your physician and the lab. Before and during your treatment, your doctor will request certain lab tests to monitor how your body is responding to the medications daratumumab and hyaluronidase-fihj.

Blood matching test results can be impacted by daratumumab and hyaluronidase-fihj while you are receiving therapy and for up to six months after your last dosage. Inform your physician and the laboratory staff that you are receiving or have recently received hyaluronidase-fihj and daratumumab injections before receiving a blood transfusion. Before you begin therapy with daratumumab and hyaluronidase-fihj, your doctor will order blood tests to determine your blood type.

Ask your chemist any queries you may have regarding hyaluronidase-fihj and daratumumab.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Darzalex Faspro®
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