The likelihood that blood clots will develop in or travel to the legs, lungs, or brain is increased after taking daprodustat. Inform your doctor whether you have heart disease now or previously had it, as well as if you’ve ever experienced a stroke. If you see any of the following symptoms, contact your doctor right away or seek emergency care: Shortness of breath, a persistent or bloody cough, chest pain, or sudden difficulty speaking or understanding speech; pain, tenderness, redness, warmth, and/or swelling in the legs; coolness or paleness in an arm or leg; unexpected difficulty walking, dizziness, loss of balance or coordination, sudden confusion, sudden weakness or numbness of an arm or leg (particularly on one side of the body), or sudden fainting. A blood clot may form in your vascular access if you are receiving hemodialysis treatment (treatment to eliminate waste from the blood when the kidneys are not functioning) (place where the hemodialysis tubing connects to your body). If your vascular access stops functioning normally, let your doctor know.

Your doctor will modify your daprodustat dosage so that your haemoglobin level the quantity of a protein found in red blood cells is just high enough that you do not require a red blood cell transfusion, which is a procedure used to treat severe anaemia by transferring another person’s red blood cells into the recipient’s body. There is a higher chance of developing serious or life-threatening heart conditions, such as heart attack and heart failure, if you receive enough daprodustat to raise your haemoglobin to a normal or close to normal level. If you suffer any of the following signs, call your doctor right away or seek emergency assistance: Shortness of breath; nausea; dizziness; sweating; chest pain, pressure, or tightness; arm, shoulder, neck, jaw, or back pain; or swollen hands, feet, or ankles are some early symptoms of a heart attack.

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to daprodustat, your doctor will request specific lab tests. If the tests reveal you are at a high risk of developing significant side effects, your doctor may lower your dose or advise you to stop taking daprodustat for a while. Carefully adhere to your doctor’s instructions.

The patient information sheet (Medication Guide) from the manufacturer will be provided to you by your doctor or chemist when you start taking daprodustat and at each time your prescription is renewed. If you have any questions, carefully read the information and ask your doctor or chemist. The Medication Guide is also available on the Food and Drug Administration (FDA) website.

The dangers of taking daprodustat should be discussed with your doctor.

Daprodustat is prescribed to persons with chronic kidney failure (a condition in which the kidneys gradually stop functioning altogether over time) who have been undergoing hemodialysis for at least 4 months to treat anaemia (a lower than usual quantity of red blood cells). Daprodustat belongs to a group of drugs known as HIF PH inhibitors. It functions by raising erythropoietin, a hormone required by the body to make more red blood cells.

Daprodustat is available as an oral tablet. It is typically taken once day, with or without food. Take daprodustat every day at about the same time. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Daprodustat should be taken as prescribed. Never take it in larger or less amounts or more frequently than directed by your doctor.

Do not chew, break, or crush the tablets; instead, swallow them whole.

Depending on the results of your lab tests, your doctor may need to modify your daprodustat dosage from time to time.

Anemia is not cured by daprodustat, although it can be controlled. Daprodustat should be taken even if you feel OK. Without consulting your doctor, do not discontinue taking daprodustat.

Ask your doctor or chemist for more details if you believe this drug should be used for something else.

Before taking daprodustat,

• If you have an allergy to daprodustat, any other medications, or any of the substances in daprodustat tablets, inform your doctor right away. For a list of the ingredients, consult the Medication Guide or speak with your pharmacist.
• Daprodustat should not be taken with certain drugs. When beginning daprodustat, make sure your doctor and pharmacist are aware of any drugs you are taking or intend to take. Please with your doctor or pharmacist before starting, stopping, or changing any medications while using daprodustat as your dose may need to be adjusted or you may need to be watched more closely.
• In case you have hypertension, tell your doctor. Your physician might advise against taking daprodustat.
• You should let your doctor know if you have or have had had cancer, liver illness, stomach ulcers, esophageal injury, or damage to the lining of the intestines.
• Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. howing. tos ing thes ing ing ing ing ing ing ing ing. ing. The foetus could suffer from daprodustat. While taking daprodustat and for one week after quitting it, you shouldn’t breastfeed.
• You should let your doctor or dentist know that you are taking daprodustat if you are having surgery, including dental surgery.
• Inquire with your doctor if drinking alcohol is safe for you to do while taking daprodustat. Daprodustat adverse effects can be exacerbated by alcohol.
• If you use tobacco products, let your doctor know. Smoking cigarettes can exacerbate daprodustat’s negative effects.

Keep eating normally unless your doctor instructs you otherwise.

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

Daprodustat might have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

• Abdomen ache
• Dizziness

Certain adverse effects can be very harmful. Call your doctor right away or seek emergency medical attention if you develop any of these signs or any of the ones detailed in the IMPORTANT CAUTION section:

• Dizziness or vomiting
• Blood in your faeces or vomit
• Tarry, black stools
• Difficulty swallowing
• Discomfort in the chest or throat

Further negative effects of daprodustat could occur. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

Keep this medication tightly closed in the original container and out of the reach of children. Keep it away from excessive heat and moisture at room temperature (not in the bathroom).

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning. http://www.upandaway.org

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at http://goo.gl/c4Rm4p for additional information.

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose symptoms could include:

• Headache
• Stomach pain, vomiting, or gastrointestinal discomfort

Keep all of your appointments with your physician and the lab. To determine how your body is responding to daprodustat, your doctor may or may not prescribe specific lab tests.

Inform the lab staff and your doctor that you are taking daprodustat prior to any laboratory test.

No one else should take your medication. Any queries you may have regarding prescription refills should be directed to your chemist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.