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Dalteparin Injection

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WARNING

You run the danger of developing a blood clot in or near your spine after an epidural, spinal anaesthetic, or spinal puncture while receiving a “blood thinner” injection like dalteparin. This could leave you paralysed. Inform your doctor whether you still have an epidural catheter in your body, recently underwent spinal anaesthesia, had spinal surgery, or have undergone recurrent epidural or spinal punctures. Also mention any spinal deformities or spinal anaesthesia complications. If you are taking any of the following, let your physician and chemist know: Agrylin’s anagrelide; aspirin and other NSAIDs including ibuprofen (Advil, Motrin, and others), indomethacin (Indocin, Tivorbex), ketoprofen, and naproxen (Aleve, Anaprox, and others), cilostazol, and clopidogrel (Plavix), as well as apixaban (Eliquis); heparin, edoxaban (Savaysa), prasugrel (Effient), rivaroxaban (Xarelto), ticagrelor (Brilinta), dipyridamole (Persantine, in Aggrenox), warfarin, and dabigatran (Coumadin, Jantoven). Call your doctor right away if you have any of the following symptoms: weakening in your muscles, particularly in your legs and feet, numbness or tingling, back discomfort, or loss of control over your bowels or bladder.

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to the dalteparin injection, your doctor will request specific tests.

Discuss the dangers of using dalteparin injection with your doctor.

Why is this medication prescribed?

Aspirin and dalteparin are combined to lessen the risk of serious or fatal consequences from angina (chest discomfort) and heart attacks. Those who are on bedrest, getting a hip replacement, or having abdominal surgery can use dalteparin to avoid deep vein thrombosis (DVT), a blood clot that typically forms in the leg, which can result in pulmonary embolism (PE), a blood clot in the lung. Children one month of age and older, as well as adults with DVT or PE who have cancer, can also receive treatment for DVT or PE and be protected from developing it again. Dalteparin belongs to a group of drugs known as anticoagulants, also known as “blood thinners.” It functions by lessening the blood’s capacity to clot.

How should this medicine be used?

Dalteparin is available as a liquid solution in vials and prefilled syringes for subcutaneous injection (under the skin). It is typically administered once daily to adults while using it, although in some circumstances it may be used twice daily. For youngsters, it is often administered twice daily. Your ailment and how well your body responds to the medication will determine how long you need to receive treatment. Dalteparin is often administered for 5 to 8 days when used to avoid complications from angina and heart attacks. Dalteparin is often administered on the day of surgery and for 5 to 10 days after surgery if it is being used to prevent DVT after surgery. Dalteparin is often given for 12 to 14 days when used to prevent DVT in patients who are on bedrest. Dalteparin may need to be taken for up to six months if you have cancer and need it to treat and prevent DVT.

You might be administered dalteparin by a nurse or other medical professional, or you might be instructed to administer the injection at home. If you plan to administer dalteparin at home, a medical professional will demonstrate how to do so. Make sure you comprehend these instructions. If you have any concerns regarding how to administer the injection, what kind of syringe to use, where on your body to administer the injection, or how to discard used needles and syringes after administering the drug, see your healthcare professional. Every day, administer the drug at around the same time(s). Ask your doctor or chemist to explain any instructions on your prescription label that you are unsure about following. Follow the dalteparin directions exactly. Use it only as directed by your doctor, neither more nor less often.

For a copy of the manufacturer’s information for the patient, ask your chemist or doctor.

Other uses for this medicine

When undergoing cardioversion, persons with atrial fibrillation or flutter (a condition in which the heart beats irregularly, raising the risk of blood clots accumulating in the body and potentially causing strokes) may also use dalteparin to assist avoid strokes or blood clots (a procedure to normalise the heart rhythm). When warfarin (Coumadin) therapy has recently begun or has been stopped, it is occasionally used to avoid clots in patients with prosthetic (surgically placed) heart valves or other disorders. It is occasionally used to avoid blood clots in patients undergoing total knee replacement surgery, hip fracture surgery, or other procedures, as well as in some pregnant women. The dangers of using this drug for your illness should be discussed with your doctor.

Ask your doctor or chemist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before using dalteparin injection,

  • If you have any allergies to dalteparin, heparin, pork products, any other drugs, or any of the substances in dalteparin injection, let your doctor and pharmacist know right away. Get a list of the ingredients from your chemist.
  • Inform your doctor and chemist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Mention all of the drugs that are listed in the IMPORTANT CAUTION section. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your doctor if you experience uncontrollable heavy bleeding anywhere on your body or if you have ever experienced low platelet counts due to a heparin reaction, which are necessary for blood to clot normally. Your physician might advise against using dalteparin.
  • Inform your doctor if you have or have ever had a bleeding disorder, such as haemophilia (a condition where the blood does not clot normally), ulcers or delicate, swollen blood vessels in your stomach or intestines, high blood pressure, endocarditis (a heart infection), a stroke or ministroke (TIA), eye disease brought on by high blood pressure or diabetes, liver or kidney disease, or high blood pressure or endocarditis. Moreover, let your doctor know if you recently underwent surgery on your eyes, spine, or brain, or if you experienced stomach or intestinal bleeding.
  • Inform your physician if you are nursing a baby, intend to become pregnant, or are already expectant. Call your doctor if you get pregnant while taking dalteparin injection.
  • Inform the surgeon or dentist that you are using dalteparin injection if you are having surgery, including dental surgery.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

If you miss a dosage, administer it as soon as you remember. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not provide a second injection.

What side effects can this medication cause?

Side effects from dalteparin injection are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Nosebleeds
  • Bruising, blisters, discomfort, or redness at the injection site

Certain adverse effects can be very harmful. Call your doctor right away or seek emergency medical attention if you develop any of these signs or any of the ones detailed in the IMPORTANT CAUTION section:

  • Uncommon bruising or bleeding
  • Dark red areas in the mouth or beneath the skin
  • Throwing up or spitting up blood or what looks like coffee grinds
  • Dark, tarry, or bloody stools
  • Urinary blood
  • Dark-brown or crimson urine
  • Lot of menstrual blood loss
  • Feeling unsteady or lightheaded
  • Rash and hives
  • Swelling of the lips, eyes, tongue, cheeks, or throat
  • Respiration or swallowing challenges

Further negative consequences from dalteparin injection are possible. If you experience any strange issues while taking this drug, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

The best way to preserve your medication will be advised by your doctor. Keep your medications at room temperature as recommended by the label. Be sure to know the right way to store your medications. 2 weeks after opening, dispose of the injection dalteparin vials.

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning. http://www.upandaway.org

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your chemist or the garbage/recycling agency in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at http://goo.gl/c4Rm4p for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose symptoms could include:

  • Uncommon bleeding
  • Urinary blood
  • Tarry, black stools
  • Simple bruising
  • Bench with a reddish tint
  • Vomit that is reddish-colored or resembles coffee grounds

What other information should I know?

Inform the lab staff and your doctor that you are receiving dalteparin injection prior to any laboratory test.

No one else should take your medication. Any queries you may have regarding prescription refills should be directed to your chemist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Fragmin®
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