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CYT (Generic Cyclophosphamide Injection)

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Why is this medication prescribed?

Hodgkin’s disease, non-lymphoma Hodgkin’s (cancer types that start in a type of white blood cell that normally fights infection), cutaneous T-cell lymphoma (CTCL), a class of immune system cancers that first manifest as skin rashes, multiple myeloma (a type of cancer of the bone marrow), and specific types of leukaemia (cancer of the white blood cells), such as include, are all treated with (ALL). In addition, it is used to treat ovarian cancer, which starts in the female reproductive system where eggs are produced, breast cancer, neuroblastoma, a cancer that starts in nerve cells and primarily affects children, and retinoblastoma, an eye cancer. Cyclophosphamide is also used to treat nephrotic syndrome, a condition marked by damage to the kidneys, in children whose condition has not improved, deteriorated, or returned despite treatment with other drugs, or in those who have had terrible side effects from other drugs. The drug cyclophosphamide belongs to the group of drugs known as alkylating agents. When used to treat cancer, cyclophosphamide slows or halts the proliferation of cancer cells within the body. Cyclophosphamide suppresses your body’s immune system when used to treat nephrotic syndrome.

How should this medicine be used?

In a doctor’s office, hospital outpatient clinic, or as a powder to be mixed with fluid and injected intravenously (into a vein), cyclophosphamide injection is available. Additionally, it can be administered intrapleurally, intraperitoneally, or intramuscularly (into a muscle) (into the chest cavity). The sort of drugs you are taking, how well your body reacts to them, and the type of cancer or disease you have all affect how long your therapy will last.

If you encounter certain adverse effects, your doctor may decide to postpone your treatment or change your dose. It is critical that you communicate your feelings to your doctor throughout your cyclophosphamide injectable therapy.

Other uses for this medicine

Additionally, a certain kind of lung cancer may occasionally be treated with cyclophosphamide injection (small cell lung cancer; SCLC). Children with Ewing’s sarcoma and rhabdomyosarcoma, both of which are bone cancers, are also treated with it. Discuss the dangers of using this drug for your illness with your doctor.

Ask your doctor or pharmacist for more details if you think this drug may be recommended for other conditions.

What special precautions should I follow?

Before receiving cyclophosphamide injection,

  • Inform your doctor and pharmacist if you have any allergies to cyclophosphamide, other alkylating agents like bendamustine (Treanda®), busulfan (Myerlan®), Busulfex®, carumustine (BiCNU®, Gliadel® Wafer), chlorambucil (Leukeran®), ifosfamide (Ifex®), lomustine (CeeNU®), melphalan (Al Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Allopurinol (Zyloprim®), cortisone acetate, doxorubicin (Adriamycin®, Doxil®), hydrocortisone (Cortef®), or phenobarbital (Luminal® Sodium) should all be mentioned. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects. Tell your doctor about every medicine you are taking, even those not on this list, as many other drugs may also interact with cyclophosphamide.
  • If you have recently had x-rays or have previously undergone treatment with other chemotherapy drugs, let your doctor know. If you have kidney or liver illness now or formerly had it, let your doctor know.
  • You should be aware that cyclophosphamide can affect a woman’s regular period and can prevent sperm from developing in a man. Although cyclophosphamide has the potential to result in permanent infertility (difficulty getting pregnant), this does not mean that you cannot become pregnant or that you cannot help another person become pregnant. Before starting this medication, women should disclose to their doctors whether they are pregnant or nursing. While undergoing chemotherapy or for a while after treatments, you shouldn’t intend to get pregnant. (Ask your doctor for more information.) To prevent conception, use a proven birth control method. The foetus could suffer from cyclophosphamide.
  • Inform the surgeon or dentist if you are having surgery, including dental surgery, that you are receiving cyclophosphamide injection.

What special dietary instructions should I follow?

While taking this medication, be sure to stay hydrated.

What side effects can this medication cause?

Cyclophosphamide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • Nausea
  • Vomiting
  • Appetite loss or weight loss
  • Abdomen ache
  • Diarrhea
  • Hair fall
  • Mouth or tongue ailment
  • Variations in skin tone
  • Nail growth or colour changes on the fingers or toes

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • Fever, chills, or other symptoms of illness in addition to a sore throat
  • Poorly or slowly heals wounds
  • Significant bruising or bleeding
  • Tarry, black stools
  • Red or uncomfortable urine
  • Rash
  • Hives
  • Itching
  • Breathing or swallowing challenges
  • Breathing difficulty
  • Cough
  • Legs, ankles, or foot swelling
  • Chest ache
  • Eyes or skin that have a yellow tint

Cyclophosphamide may make you more likely to get other cancers. Discuss the dangers of obtaining an injection of cyclophosphamide with your doctor.

Other negative effects of cyclophosphamide are possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

The hospital or other healthcare facility where you receive each dose will keep this drug on hand.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  • Crimson urine
  • Black, tarry stools
  • Significant bruising or bleeding
  • Unexpected fatigue or weakened state
  • Fever, cough, sore throat, or other infection-related symptoms
  • Swelling in the legs, ankles, or foot
  • Chest discomfort

What other information should I know?

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to cyclophosphamide, your doctor will request specific lab tests.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Cytoxan® Injection
  • Neosar® Injection
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