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Cyramza (Generic Ramucirumab Injection)

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Why is this medication prescribed?

When existing treatments are ineffective for treating stomach cancer or cancer around the junction of the stomach and oesophagus (the tube connecting the throat and stomach), ramucirumab injection is administered alone or in conjunction with another chemotherapy drug. A specific kind of non-small cell lung cancer (NSCLC) that has spread to other body parts is also treated with ramucirumab in combination with docetaxel in patients who have already undergone chemotherapy but whose condition has not improved or gotten worse. It is additionally used in conjunction with erlotinib (Tarceva) to treat a specific kind of NSCLC that has metastasized to other body regions. Ramucirumab is also used in conjunction with other chemotherapy drugs to treat colon (large intestine) or rectum cancer that has spread to other regions of the body in patients who have already undergone chemotherapy but whose condition has not improved or gotten worse. In some cases, hepatocellular carcinoma (HCC), a kind of liver cancer, is treated with ramucirumab alone after sorafenib therapy (Nexafar). Monoclonal antibodies are a class of drugs that includes ramucirumab. It functions by halting the development of cancer cells.

How should this medicine be used?

A doctor or nurse will provide ramucirumab injection as a liquid over the course of 30 or 60 minutes in a hospital or other medical institution. It is often administered once every two weeks to treat HCC, colon cancer, and stomach cancer. Ramucirumab is typically used once every two weeks in combination with erlotinib to treat NSCLC. Ramucirumab is typically administered once every three weeks in conjunction with docetaxel to treat NSCLC. The effectiveness of the drug on your body and any adverse effects you encounter will determine how long you need to receive treatment.

If you encounter certain adverse effects, your doctor may need to pause or discontinue your therapy. Before you receive each dosage of the ramucirumab injection, your doctor will administer additional medications to prevent or treat certain side effects. If you encounter any of the following while on ramucirumab, inform your doctor or nurse: body shaking that is uncontrollable, back pain or muscle spasms, tightness in the chest, chills, flushing, shortness of breath, wheezing, discomfort, burning, prickling, or tingling in the hands or feet or on the skin, breathing issues, or a rapid heartbeat.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving ramucirumab injection,

  • If you have an allergy to ramucirumab, any other drugs, or any of the ingredients in ramucirumab injection, inform your doctor and pharmacist right away. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • If you have or have previously had high blood pressure, thyroid, or liver illness, let your doctor know. Additionally, let your doctor know if you have an open wound that hasn’t fully healed or if you have an injury while undergoing treatment that isn’t healing completely.
  • Ramucirumab may make it harder for women to get pregnant, which is something you should be aware of, but it doesn’t mean you can’t. If you are pregnant or want to become pregnant, let your doctor know. A pregnancy test should be done before you begin treatment. Throughout your treatment and for at least three months after it is finished, you should use birth control to avoid getting pregnant. Discuss effective birth control options with your doctor. Call your doctor right away if you find out you’re pregnant while receiving ramucirumab injectable therapy. The foetus could suffer from ramucirumab.
  • Describe to your doctor if you are nursing a baby. For two months following your final dosage of ramucirumab and while you are receiving therapy, you shouldn’t breastfeed.
  • Inform the surgeon or dentist that you are receiving ramucirumab injection if you are undergoing surgery, including dental surgery. It’s possible that your doctor will advise against getting ramucirumab injections in the 28 days leading up to surgery. Ramucirumab injection therapy may only be resumed once at least 14 days have passed since your operation and the wound has healed.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

If you are unable to keep a scheduled appointment to receive a dosage of ramucirumab injection, call your doctor right once.

What side effects can this medication cause?

The injection of ramucirumab may have adverse effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Diarrhea
  • Mouth or throat sores

Some adverse effects can be very harmful. Call your doctor right away if you have any of these signs or any of those in the IMPORTANT WARNING section:

  • Abrupt onset of arm or leg weakness
  • One side of the face is sagging
  • Trouble comprehending or speaking
  • Crushing shoulder or chest discomfort
  • Slow or challenging speech
  • Chest ache
  • Breathing difficulty
  • Headache
  • Faintness or dizziness
  • Seizures
  • Confusion
  • Loss or modification of eyesight
  • Extreme fatigue
  • Edoema of the lower legs, hands, feet, ankles, stomach, face, eyes, or stomach
  • Rise in weight without cause
  • Frothing urine
  • Persistent cough and congestion, a fever, chills, or other symptoms of infection
  • Lightheadedness, unusual bleeding or bruising, pink, crimson, or dark brown urine, red or tarry black bowel motions, or coughing up or vomiting blood or what seems to be coffee grounds.
  • Abdomen discomfort, nausea, vomiting, fever, or chills

Other adverse effects from ramucirumab injection are possible. If you experience any strange issues while taking this drug, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What other information should I know?

Keep all of your appointments with your physician and the lab. Before you start treatment for some illnesses, your doctor might request a lab test to determine whether ramucirumab can be used to treat your malignancy. Throughout your ramucirumab treatment, your doctor will routinely monitor your blood pressure and do a urine test.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Cyramza®
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