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Cycrin (Generic Medroxyprogesterone)

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Why is this medication prescribed?

Medroxyprogesterone is used to treat abnormal menstruation (periods) or irregular vaginal bleeding. Medroxyprogesterone is also used to bring on a normal menstrual cycle in women who menstruated normally in the past but have not menstruated for at least 6 months and who are not pregnant or undergoing menopause (change of life). Medroxyprogesterone is also used to prevent overgrowth of the lining of the uterus (womb) and may decrease the risk of cancer of the uterus in patients who are taking estrogen. Medroxyprogesterone is in a class of medications called progestins. It works by stopping the growth of the lining of the uterus and by causing the uterus to produce certain hormones.

How should this medicine be used?

Medroxyprogesterone is available as an oral tablet. On specific days throughout a typical monthly cycle, it is typically taken once each day. Medroxyprogesterone should be taken on the days you are supposed to take it at roughly the same time each day to help you remember to take it. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Follow the prescription for medroxyprogesterone precisely. Never take it in larger or less amounts or more frequently than directed by your doctor.

Your problem may be controlled but not cured with medroxyprogesterone. Even if you feel good, keep taking medroxyprogesterone as directed on a monthly basis. Without consulting your doctor, do not discontinue taking medroxyprogesterone.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking medroxyprogesterone,

  • Inform your physician and pharmacist if you have any drug allergies you need to discuss before taking medroxyprogesterone (Provera, Depo-Provera).
  • Inform your physician and pharmacist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are taking. Mention aminoglutethimide if you can (Cytadren). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your doctor if you have or have ever had any of the following conditions: breast or female organ cancer; unexplained vaginal bleeding; missed abortion (pregnancy that ended when the foetus died in the uterus but was not expelled from the body); stroke or mini-stroke; seizures; migraine headaches; depression; asthma; diabetes; heart, kidney, or liver disease.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Call your doctor right away if you get pregnant while taking medroxyprogesterone. During the first few months of pregnancy, medroxyprogesterone should never be used to detect pregnancy or to stop miscarriage. The foetus could be harmed by medroxyprogesterone, which has not been proven to stop miscarriages.
  • Inform the surgeon or dentist that you are taking medroxyprogesterone if you are having surgery, including dental surgery.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

Side effects from medroxyprogesterone are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Sensitive breasts or those that are liquid-producing
  • Modifications to menstrual flow
  • Irregular spotting or bleeding in the vagina
  • Acne
  • Facial hair growth
  • Hair loss on the scalp
  • Having trouble falling or staying asleep
  • Drowsiness
  • Uneasy stomach
  • Loss or increase of weight

Some adverse effects can be very harmful. Even though the following signs are unusual, you should call your doctor right once if you notice any of them:

  • One leg only may experience discomfort, swelling, warmth, redness, or tenderness.
  • Slow or challenging speech
  • Faintness or dizziness
  • Arm or leg that is weak or numb
  • Breathing difficulty
  • Spitting blood
  • Sudden, severe, or debilitating chest discomfort
  • Hammering or rapid heartbeat
  • Unexpected changes in vision or vision loss
  • Dual perception
  • Fuzzy vision
  • Enlarged eyes
  • Absent periods
  • Depression
  • Eyes or skin that have a yellow tint
  • Fever
  • Hives
  • Body rash
  • Itching
  • Breathing or swallowing challenges
  • Edoema of the lower legs, ankles, feet, or hands

When fed medroxyprogesterone, several laboratory animals developed breast cancers. It is unknown if medroxyprogesterone makes people more susceptible to developing breast cancer. Additionally, medroxyprogesterone may raise your risk of developing a blood clot that travels to your lungs or brain. The dangers of using this drug should be discussed with your doctor.

Other negative consequences of medroxyprogesterone are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Store it away from excessive heat and moisture at room temperature (not in the bathroom).

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at for additional information.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your doctor’s appointments.

Inform the lab staff and your doctor that you are taking medroxyprogesterone prior to any laboratory test.

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Amen®
  • Curretab®
  • Cycrin®
  • Prodroxy®
  • Provera®
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