Cyclosporine injection must be administered under the care of a medical professional with expertise in managing transplant patients and writing prescriptions for drugs that lower immune system activity.

Receiving cyclosporine injections may increase your risk of contracting an infection or cancer, particularly skin cancer and lymphoma, which are diseases of the immune system. If you receive cyclosporine injection along with other treatments such azathioprine (Imuran), cancer chemotherapy, methotrexate (Rheumatrex), sirolimus (Rapamune), and tacrolimus, your risk may increase (Prograf). Inform your doctor if you’re taking any of these drugs and if you currently have or have ever had cancer of any kind. Please see your physician right away if you suffer any of the following symptoms: A sore throat, fever, chills, and other symptoms of infection; flu-like symptoms; coughing; difficulty urinating; pain when urinating; lumps or masses anywhere on the body; night sweats; swollen glands in the neck, armpits, or groyne; difficulty breathing; chest pain; weakness or fatigue that does not go away; or pain, swelling, or fullness in the stomach.

Discuss the dangers of obtaining a cyclosporine injection with your doctor.

For those who have had kidney, liver, or heart transplants, cyclosporine injection is combined with other drugs to prevent transplant rejection (the immune system of the recipient’s body attacking the transplanted organ). Only those who are unable to take cyclosporine orally should receive treatment with cyclosporine injection. Immunosuppressants are a group of drugs that includes cyclosporine. It functions by reducing immune system activity.

A doctor or nurse will often provide cyclosporine injection as a solution (liquid) over the course of 2 to 6 hours into a vein in a hospital or other healthcare setting. It is often administered 4 to 12 hours prior to transplant surgery and once per day following the procedure until oral medication can be used.

While you receive the cyclosporine injection, a doctor or nurse will keep a careful eye on you so that you can be swiftly treated if you experience a severe allergic response.

Additionally, patients who have received pancreatic or corneal transplants may also take cyclosporine injection to avoid rejection. Crohn’s disease is a condition in which the body attacks the lining of the digestive tract, resulting in discomfort, diarrhoea, weight loss, and fever. The dangers of using this drug for your illness should be discussed with your doctor.

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

Before receiving cyclosporine injection,

• If you have an allergy to Cremophor EL, any other drugs, or cyclosporine (Gengraf, Neoral, Sandimmune), let your doctor and pharmacist know right away.
• Inform your doctor and pharmacist about any prescription and over-the-counter drugs, vitamins, and dietary supplements you are currently taking or intend to take. Mention the drugs in the IMPORTANT WARNING section as well as any of the following: Allopurinol (Zyloprim), acyclovir (Zovirax); a iodarone (Cordarone), amphotericin B (Amphotec, Fungizone), angiotensin-converting enzyme (ACE) inhibitors like benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc); candesartan (Atacand), eprosartan (Teveten), irbesartan (Avapro), losartan (Cozaar), olmesartan (Benicar), telmisartan (Micardis), and valsartan (Diovan) are examples of angiotensin II receptor antagonists. Azithromycin (Zithromax), bromocriptine (Parlodel), certain antifungal medications like fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral), calcium channel blockers such diltiazem (Cardizem), nicardipine (Cardene), nifedipine (Adalat, Procardia), and verapamil (Calan); cimetidine (Tagamet); ciprofloxacin (Cipro); carbamazepine (Carbitrol, Epitol, Tegretol); cholesterol-lowering drugs (statins) such as atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor), pravastatin (Pravachol), and simvastatin (Zocor); erythromycin (E.E.S., E-Mycin, Erythrocin), fenofibrate (Antara, Lipophen, Tricor), gentamicin; colchicine; dalfopristin and quinupristin combination (Synercid); danazol; digoxin (Lanoxicaps, Lanoxin); certain diuretics (‘water pills’), such as amiloride (in Hydro-ride); HIV protease inhibitors such indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Fortovase), imatinib (Gleevec), metoclopramide (Reglan), methylprednisolone (Medrol), nafcillin, and nonsteroidal anti-inflammatory drugs like diclofenac (Cataflam, Voltaren), Prednisolone (Pediapred), phenobarbital, phenytoin (Dilantin), orlistat (alli, Xenical), potassium supplements, octreotide (Sandostatin), hormonal contraceptives (birth control pills, patches, implants, and injections); ranitidine (Zantac); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane); vancomycin, trimethoprim-sulfamethoxazole (Bactrim, Septra), sulfinpyrazone (Anturane), terbinafine (Lamisil), ticlopidine (Ticlid), tobramycin (Tobi), and trimethoprim-sulfamethoxazole (Vancocin). Your physician might need to adjust the dosage of your drugs or keep a closer eye on you for adverse effects.
• Inform your doctor about any herbal supplements you are now using or intend to use, including St. John’s wort.
• Inform your doctor if you are using phototherapy (a psoriasis treatment that involves exposing the skin to ultraviolet light) and if you currently have or ever had high blood pressure, low levels of magnesium or cholesterol.
• If you are pregnant or plan to become pregnant, let your doctor know. Call your doctor right away if you get pregnant while having cyclosporine injection. A cyclosporine injection could make it more likely that your child will be born too soon.
• If you are currently breastfeeding or plan to do so, let your doctor know.
• Avoid getting shots without first consulting your doctor.
• You should be aware that cyclosporine may result in more gum tissue growth. You lessen the likelihood that you will experience this side effect, make sure to wash your teeth thoroughly and visit the dentist frequently while you are receiving treatment.

While getting a cyclosporine injection, avoid eating or drinking grapefruit.

Your physician could advise you to restrict the potassium in your diet. Pay close attention to these directions. Consult your doctor about your dietary intake of foods high in potassium, such as bananas, prunes, raisins, and orange juice. Ask your doctor if you can use potassium-containing salt alternatives while you’re undergoing therapy.

There could be negative effects from cyclosporine injection. If any of these symptoms are severe or do not go away, let your doctor know right once:

• Headache
• Diarrhea
• Nausea
• Vomiting
• Increased facial, arm, and back hair development
• Swelling of the gums or the development of additional tissue there
• Acne
• Uncontrolled trembling in a bodily component
• Hands, arms, feet, or legs experiencing discomfort, burning, numbness, or tingling
• Cramps
• Male breast enlargement

Some adverse effects can be very harmful. Call your doctor right away if you have any of these signs or any of those in the IMPORTANT WARNING section:

• Facial or chest flushing
• Breathing difficulty
• Wheezing
• Rapid heart rate
• Rash
• Hives
• Itching
• Having trouble swallowing
• Consciousness is lost
• Seizures
• Alterations in behaviour or mood
• Having trouble moving
• Eyesight issues or unexpected blackouts
• Edoema of the lower legs, lower arms, feet, ankles, or hands

Other negative effects from cyclosporine injection are possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Keep all of your appointments with your physician and the lab. In order to monitor your body’s reaction to the cyclosporine injection, your doctor will request specific lab tests.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.