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Crysvita (Generic Burosumab-twza Injection)

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Why is this medication prescribed?

Burosumab-twza injection is used to treat adults and children 6 months of age and older with X-linked hypophosphatemia (XLH; an inherited illness where the body doesn’t manage phosphorus and that causes weak bones). Burosumab-twza injection belongs to the class of drugs known as fibroblast growth factor 23 (FGF23) blocking antibodies and is used to treat tumor-induced osteomalacia (a tumour that causes a loss of phosphorus in the body, resulting in weak bones) in adults and children 2 years of age and older that cannot be removed surgically. It functions by impeding the body’s natural chemical that triggers the symptoms of XLH.

How should this medicine be used?

A doctor or nurse must administer the burosumab-twza injection as a solution (liquid) subcutaneously (under the skin). It is typically administered once every two weeks for children 6 months to 17 years old and once every four weeks for adults to treat X-linked hypophosphatemia. It is typically injected once every two weeks into youngsters 2 to 17 years old for the treatment of tumor-induced osteomalacia. It is typically injected every 4 weeks for the treatment of tumor-induced osteomalacia in adults, but when the dose is increased, it may be given every 2 weeks. Each time, your doctor or nurse will choose a different injection site, such as your upper arm, upper thigh, buttocks, or stomach region.

If you take any phosphate supplements or specific vitamin D supplements like calcitriol (Rocaltrol) or paricalcitol, let your doctor know (Zemplar). One week before starting treatment, you must stop taking them.

In accordance with the findings of your lab tests, your doctor may change your dose (but no more than once every four weeks) or omit a dose.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before using burosumab-twza injection,

  • If you have any allergies, including to any inactive substances in burosumab-twza injection, tell your doctor right away. Get a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products that you are now taking or intend to use. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • In case you have kidney illness, let your doctor know. Burosumab-twza injection may not be used, according to your doctor.
  • If you have or have ever had restless leg syndrome, let your doctor know (RLS; a condition that causes discomfort in the legs and a strong urge to move the legs, especially at night and when sitting or lying down).
  • Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. Call your doctor if you get pregnant while having burosumab-twza injectable.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

Make another appointment as soon as you can if you miss a dosing appointment.

What side effects can this medication cause?

The injection of burosumab-twza may have adverse effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Headache
  • Vomiting
  • Fever
  • Back, leg, or arm pain
  • Muscular ache
  • Constipation
  • Dizziness

Certain adverse effects can be very harmful. Call your doctor if you notice any of these signs:

  • The injection site is accompanied by redness, rash, hives, itching, swelling, discomfort, or bruising
  • Hives or a rash
  • Strong want to move one’s legs, especially when sitting or lying down or at night, and leg discomfort

Further adverse effects after burosumab-twza injection are possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What other information should I know?

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to the burosumab-twza injection, your doctor will order specific lab tests both before and after your therapy.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Crysvita®
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