Penicillin G injection is used to treat and prevent certain infections caused by bacteria. A group of medicines known as penicillins includes penicillin G injection. It functions by eradicating the infection-causing germs.

Colds, the flu, and other viral diseases cannot be treated with antibiotics such as penicillin G injection. Antibiotic use that is not necessary raises the likelihood of developing a later infection that is resistant to antibiotic treatment.

Both a powder to be mixed with water and a premixed solution are available for penicillin G injection. Penicillin G injection is typically administered via injection into a muscle or vein, but it can also be administered directly into the fluid surrounding the spinal cord, the lining of the chest cavity, a joint, or other locations. Your general health, the type of infection you have, and how well you respond to the medication will all influence how many doses you will take daily and how long it will take you to complete your course of treatment.

You can either administer penicillin G injection at home or get it in a hospital. If you will be taking penicillin G injection at home, your doctor will instruct you on how to administer the drug. Make sure you comprehend these instructions, and if you have any issues, consult your healthcare professional.

You should begin to feel better during the first few days of treatment with penicillin G injection. If your symptoms do not improve or get worse, call your doctor.

Use penicillin G injection for as long as your doctor tells you that you should, even if you feel better. If you stop using penicillin G injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

You may experience a reaction starting one or two hours after receiving your first dose of this medication and lasting for 12 to 24 hours if you are using penicillin G injection to treat certain infections such as syphilis (a sexually transmitted disease), Lyme disease (a disease spread by tick bites that may cause issues with the heart, joints, and nervous system), or relapsing fever (a disease spread by tick bites that causes repeated episodes of fever). Any of the following symptoms, including fever, chills, muscle aches, headache, worsening of skin sores, rapid heartbeat, rapid breathing, and flushing, should be reported to your doctor.

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

Before receiving penicillin G injection,

• Inform your doctor and pharmacist if you have any allergies to penicillin G injection, penicillin antibiotics, cephalosporin antibiotics, such as cefoxitin, cefpodoxime, cefprozil, ceftazidime (Fortaz, Tazicef), ceftibuten (Cedax), and ceftriaxone, as well as penicillin and cephalosporin antibiotics (Rocephin), cephalexin (Keflex), cefuroxime (Ceftin, Zinacef), or any other drugs. If you are unsure whether a drug you are allergic to falls under one of these categories, see your doctor or pharmacist. If you have a reaction to any of the components in penicillin G injection, let your doctor know right once. Request a list of the components from your pharmacist.
• Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Incorporate any of the following: Aspirin, chloramphenicol, erythromycin (Ery-tab, E.E.S., others), indomethacin (Indocin, Tivorbex), probenecid (Probalan), sulfa antibiotics, and tetracycline are examples of “water pills” or diuretics (Achromycin). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
• Inform your doctor if you have or have ever had asthma, allergies, hay fever, hives, heart failure, renal disease, or liver illness. Also let them know if you follow a low sodium or potassium diet.
• Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. Call your doctor if you conceive while having an injection of penicillin G.

Keep eating normally unless your doctor instructs you otherwise.

The missed dose should be taken as soon as you remember. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

The injection of penicillin G could have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

• Nausea
• Vomiting
• The area where the drug was injected may experience pain, edoema, or redness

Some side effects can be serious. If you experience any of these symptoms, stop using penicillin G injection and call your doctor immediately or get emergency medical treatment:

• Rash
• Hives
• Itching
• Breathing or swallowing challenges
• Edoema of the hands, feet, ankles, lower legs, cheeks, neck, tongue, lips, and eyes
• Hoarseness
• Fever
• Joint or muscle ache
• Abdominal pain
• After your therapy, you may experience severe diarrhoea (watery or bloody stools) with fever and/or stomach cramps for up to 2 months or longer
• Uncommon bruising or bleeding
• Urine with blood in it
• Seizures
• Weakness
• Irregular, quick, or sluggish heartbeat
• Fever, chills, sore throat, or other signs of infection returning

Penicillin G injection may produce various negative effects. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Symptoms of overdose may include the following:

• Agitation
• Confusion
• Jerking actions
• Seeing or hearing things or voices that are not there
• Seizures
• Coma
• Weakness
• Irregular, quick, or sluggish heartbeat

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to the injection of penicillin G, your doctor will request a few lab tests.

Inform the lab staff and your doctor that you are receiving a penicillin G injection prior to any laboratory test.

Use Clinistix or TesTape (not Clinitest) to test your urine for sugar if you have diabetes and are taking this medicine.

If you have any inquiries regarding penicillin G injection, ask your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.