When surgery is ineffective or the melanoma has migrated to other parts of the body, cobimetinib is used in combination with vemurafenib (Zelboraf) to treat the condition. Furthermore, histiocytic neoplasms are treated with cobimetinib (conditions that cause an overproduction and accumulation of a type of white blood cell in parts of the body). A group of drugs known as kinase inhibitors includes cobimetinib. It operates by obstructing the function of an aberrant protein that instructs cancer cells to proliferate. This aids in reducing or halting the growth of cancerous cells.

The drug cobimetinib is available as a tablet to be swallowed with or without food. Typically, the first 21 days of a 28-day cycle are taken once daily. Take cobimetinib every day at roughly the same time. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Follow the prescription for cobimetinib exactly. Never take it in larger or less amounts or more frequently than directed by your doctor.

Do not take another dose of cobimetinib if you vomit after taking it. Continue taking your medication as usual.

Your doctor may lower your cobimetinib dosage or temporarily or permanently cease your medication. The effectiveness of the drug and any negative side effects you encounter will determine this. Throughout your cobimetinib therapy, be careful to let your doctor know how you are feeling.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

Before taking cobimetinib,

• If you have any allergies, including to cobimetinib, other drugs, or any of the substances in cobimetinib tablets, notify your doctor right away. Get a list of the components from your pharmacist.
• Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, and dietary supplements you are currently taking or intend to take. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
• Please let your doctor know if you are taking any herbal supplements, especially St. John’s Wort. St. John’s Wort should not be consumed when using cobimetinib.
• Inform your doctor if you currently have or have previously had any of the following disorders: heart or liver disease, a condition that affects your muscles, blood issues, eyesight issues, or skin conditions other than melanoma.
• You should be aware that cobimetinib may reduce both male and female fertility. Yet, you shouldn’t presumptively believe that neither you nor your partner could conceive. If you are pregnant or want to become pregnant, let your doctor know. Employ an effective birth control technique to avoid getting pregnant while receiving medication and for two weeks after stopping cobimetinib. Discuss effective birth control options with your doctor. Call your doctor right away if you conceive while taking cobimetinib. The foetus may suffer from cobmetinib.
• If you are breastfeeding, let your doctor know. If you are on cobimetinib, you should stop breastfeeding for two weeks following your last dosage.
• Make a plan to limit your time spent in the sun, wear sunscreen, protective clothing, sunglasses, and lip balm (SPF 30 or higher). Your skin could become sun-sensitive if you take cobimetinib. If you have a sunburn, tell your doctor as soon as possible.

While using this medication, avoid grapefruit and grapefruit juice.

Ignore the missed dose and carry on with my normal dosing routine. To make up for a missing dose, do not take a second one.

There may be negative consequences from cobimetinib. If any of these symptoms are severe or do not go away, let your doctor know right once:

• Mouth ulcers
• Hair fall
• Diarrhea
• Nausea
• Vomiting
• Stomach pain or indigestion
• Mouth ache
• Frequent or painful urination, fever, chills, sore throat, or other indicators of infection
• Falling

Certain adverse effects can be very harmful. Call your doctor right away or seek emergency medical attention if you have any of these symptoms or any of those listed in the SPECIAL PRECAUTIONS section:

• Rash that covers a lot of your body, blisters, or skin that is peeling off
• Skin appearance changes
• Fresh wart
• Painful or red bump on the skin that bleeds or does not go away
• Mole’s alteration in size or colour
• Blood in the urine, unusual vaginal bleeding, unusual bruising or bleeding, stomach pain, headaches, or dizziness
• Shortness of breath, fatigue, a racing or pounding heartbeat, wheezing, or swelling of the face, arms, legs, ankles, or feet
• Weakness, discomfort, or muscular spasms
• Visual modifications, such as halos (a fuzzy outline surrounding things), impaired vision, or vision loss
• Dark (tea-colored) urine, pain in the upper right side of the stomach, nausea, vomiting, or loss of appetite are all signs of yellowing of the skin or eyes.

It’s possible that cobometinib will make it more likely that you’ll have new skin malignancies. The dangers of using this drug should be discussed with your doctor.

Further negative effects of cobimetinib are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

Keep this medication tightly closed in the original container and out of the reach of children. Keep it away from excessive heat and moisture at room temperature (not in the bathroom).

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at http://goo.gl/c4Rm4p for additional information.

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning. http://www.upandaway.org

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Keep all of your appointments with your physician and the lab. To monitor your body’s response throughout and after therapy, your doctor will request specific lab tests. Before, every two months throughout your treatment, and for up to six months after, your doctor will examine your skin for any changes.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.