For treating people with small cell lung cancer with chemotherapy, tilacilib injection is used to reduce the risk of myelosuppression (a reduction in red blood cells, white blood cells, and platelets) (SCLC). The drug trilaciclib belongs to the group of drugs known as kinase inhibitors. To prevent the immune system and bone marrow cells from being harmed by chemotherapy, it works by preventing the actions of specific chemicals in the body.

In a doctor’s office or healthcare institution, a nurse or doctor will use trilaciclib, which is sold as a powder to be dissolved in liquid and administered intravenously. Usually, it is infused for 30 minutes four hours before chemotherapy.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

Before receiving trilaciclib,

• If you have any allergies, including to trilaciclib, any other drugs, or any of the substances in trilaciclib injection, notify your doctor right away. Get a list of the components from your pharmacist.
• Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Incorporate any of the following: cisplatin, dofetilide (Tikosyn), dalfampridine (Ampyra), and metformin (Glucophage). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects. Tell your doctor about all of the medications you are taking, even any not on this list, since many other drugs may also interact with trilaciclib.
• If you have or have previously had any medical issues, let your doctor know.
• If you are pregnant or plan to become pregnant, let your doctor know. Pregnancy testing will be required before you begin therapy, and you should use birth control to avoid getting pregnant both throughout treatment and for at least 3 weeks following your last dosage. In the event that you conceive while taking trilaciclib, contact your physician right away. The foetus could suffer from trilaciclib.
• If you are currently breastfeeding or intend to do so, let your doctor know. While using trilaciclib and for at least 3 weeks following your last dose, you shouldn’t breastfeed.

Keep eating normally unless your doctor instructs you otherwise.

The injection of trilaciclib may have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

• Tiredness
• Headache
• Right upper abdominal discomfort

Certain adverse effects can be very harmful. Call your doctor right away if you encounter any of these symptoms, or seek emergency care:

• Infection-related symptoms such as fever, coughing, and shortness of breath
• Pain, bruising, swelling, warmth, or itching at the injection site
• Patch of skin that is swollen, heated, and red
• Enlargement of the tongue, eyes, and face
• Breathing or swallowing challenges
• Rash
• Itching
• Hives

Further negative effects from trilaciclib injection are possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to the injection of trilaciclib, your doctor may request specific lab tests.

Ask any inquiries you may have regarding trilaciclib to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.