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Cortisporin Otic Solution (Generic Neomycin, Polymyxin, and Hydrocortisone Otic)

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Why is this medication prescribed?

The combination of neomycin, polymyxin, and hydrocortisone otic drops is used to treat bacterial outer ear infections. Infections of the outer ear, which might develop after specific kinds of ear surgery, are also treated with it. Neomycin and polymyxin belong to the category of drugs known as antibiotics. They function by halting bacterial growth. A group of drugs known as corticosteroids includes hydrocortisone. It works by causing the ear’s natural chemicals to become active, which lessens swelling, redness, and itching.

How should this medicine be used?

Neomycin, Polymyxin, and Hydrocortisone Otic Combination is available as a liquid solution or a liquid suspension for insertion into the ear. For up to 10 days, it is often applied to the affected ear or ears three to four times each day. Take a mixture of neomycin, polymyxin, and hydrocortisone otics at roughly the same times each day. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Follow the manufacturer’s instructions for using the neomycin, polymyxin, and hydrocortisone otic mixture. Use it only as directed by your doctor, neither more nor less often.

Only use neomycin, polymyxin, and hydrocortisone otic solution in the ears. Use away from the eyes.

After the first few days of treatment with neomycin, polymyxin, and hydrocortisone otic combo, your symptoms ought to start to get better. Call your doctor if your symptoms don’t go away after a week or worsen.

Use the eardrops as directed to get started:

  • Warm the solution by holding the bottle in your hand for a couple of minutes.
  • If using the suspension, give the bottle a good shake.
  • Using a sterile cotton applicator, carefully clean and dry the afflicted ear canal.
  • Lay down while elevating the impacted ear.
  • Fill your ear with the recommended quantity of drops.
  • Avoid touching the dropper tip to your fingers, ears, or any other objects.
  • For five minutes, continue to lay down with the effected ear pointed upward.
  • If necessary, repeat steps 1-6 for the other ear. If you’d like, you can insert a cotton wick into the ear canal before saturating it with ear drops. Every 24 hours at the very least, the wick needs to be changed.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before using neomycin, polymyxin, and hydrocortisone otic combination,

  • Inform your physician and pharmacist if you have any allergies to neomycin (Neo-Fradin, Mycifradin, among other brands), polymyxin, hydrocortisone (Anusol HC, Cortef, among other brands), aminoglycoside antibiotics like amikacin, gentamicin (Gentak, Genoptic), kanamycin, paromomycin, streptomycin, and tobramycin (Tobrex, Get a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • If you have a hole or tear in your ear drum or an ear infection brought on by a virus like chickenpox or herpes, let your doctor know. The combination of neomycin, polymyxin, and hydrocortisone otic will likely be discouraged by your doctor.
  • Inform your doctor of any medical conditions you now have or have ever had.
  • Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. Call your doctor if you become pregnant while taking the combination of neomycin, polymyxin, and hydrocortisone otic.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

The missed dose should be taken as soon as you remember. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a forgotten dose, don’t use more ear drops.

What side effects can this medication cause?

The combination of neomycin, polymyxin, and hydrocortisone may have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Scorching or stinging following the injection of the medicine
  • Thinned skin
  • Little skin lumps that are white or red
  • Acne
  • Excessive hair growth
  • Skin tone varies

Certain adverse effects can be very harmful. Neomycin, Polymyxin, and Hydrocortisone Otic Combination should not be continued if any of the following symptoms occur:

  • Hearing loss that could last a lifetime
  • Skin edoema, erythema, or itchiness
  • Scaling or dry skin
  • Less urinations
  • Swelling in the ankles, foot, or legs
  • Unexpected fatigue or weakened state

The combination of neomycin, polymyxin, and hydrocortisone may result in additional adverse effects. If you experience any strange issues while taking this drug, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Keep it away from excessive heat and moisture at room temperature (not in the bathroom).

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your doctor’s appointments.

No one else should take your medication.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Cortisporin Otic Solution® (as a combination product containing Neomycin, Polymyxin, Hydrocortisone)
  • Casporyn HC Otic Suspension® (as a combination product containing Neomycin, Polymyxin, Hydrocortisone)
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