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Corticotropin, Repository Injection

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Why is this medication prescribed?

The following conditions are treated with corticotropin repository injection:

  • Infantile spasms in infants and young children under the age of two (seizures that often start within the first year of life and may be followed by developmental delays);
  • Bouts of symptoms in those with multiple sclerosis (MS; a condition wherein patients may experience weakness, numbness, lack of muscle coordination, and issues with vision, speech, and bladder control);
  • Bouts of rheumatoid arthritis (a disorder in which the body attacks its own joints, resulting in pain, swelling, and loss of function) symptoms in patients;
  • Bouts of psoriatic arthritis symptoms (a disorder that creates scales on the skin, along with joint pain and swelling);
  • Ankylosing spondylitis (a disorder in which the body attacks the joints in the spine and other places, causing pain and joint destruction) bouts of symptoms;
  • The disease lupus (in which the body attacks several of its own organs);
  • Systemic polymyositis, which produces muscle weakness but not skin rash, or systemic dermatomyositis, which causes both muscle weakness and skin rash;
  • Stevens-Johnson syndrome is one of the more severe allergic reactions that can result in blistering and shedding of the top layer of skin;
  • A severe allergic reaction that involves skin rash, fever, joint pain, and other symptoms several days after taking a particular medicine is known as serum sickness;
  • Edoema of the eyes and the area around them may be caused by allergic responses or other illnesses;
  • Sarcoidosis (disease in which immune cells clump together and affect the function of several organs, including the heart, lungs, eyes, skin, and skin);
  • Kidney disease (a group of symptoms including protein in the urine; low levels of protein in the blood; high levels of certain fats in the blood; and swelling of the arms, hands, feet, and legs).

An example of a hormone medicine is corticotropin repository injection. It cures a variety of ailments by reducing immune system activity so that organ damage won’t result. The effectiveness of corticotropin repository injection in treating infantile spasms cannot be determined from the available data.

How should this medicine be used?

The corticotropin repository injection is a long-acting gel that is injected into the muscle or beneath the skin. When used to treat infantile spasms, corticotropin repository injection is typically administered twice daily for two weeks, followed by another two weeks of injections on a gradually reducing frequency. When used to treat multiple sclerosis, corticotropin repository injection is typically administered once day for two to three weeks before the dosage is gradually reduced. Depending on the illness being treated and how well the medication works to treat the ailment, corticotropin repository injection is given once every 24 to 72 hours when treating other conditions. On each day that you are instructed to provide it, administer corticotropin repository injection at around the same time(s) of day. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Follow the instructions for corticotropin repository injection exactly. Use it only as directed by your doctor, neither more nor less often.

As long as your doctor has recommended corticotropin repository injection, keep using it. Without consulting your doctor, do not stop taking corticotropin repository injection. You can have symptoms like weakness, fatigue, pale complexion, changes in skin colour, weight loss, stomach pain, and loss of appetite if you abruptly stop using corticotropin repository injection. Your dose will likely be gradually reduced by your doctor.

You can administer the corticotropin repository injection drug yourself, or you can ask a friend or relative to do it for you. Before you inject the drug for the first time at home, you or the person giving the injections should read the manufacturer’s instructions. Your doctor will demonstrate how to administer the injections to you or the person who will be administering the medication, or your doctor may arrange for a nurse to visit your house to demonstrate how to administer the injections.

A needle and syringe are required to administer corticotropin. Find out from your doctor what kind of syringe and needle to use. Never reuse a syringe or needle, and never share one. Put used syringes and needles in a container that won’t puncture. For disposal instructions on the puncture-proof container, consult your doctor or pharmacist.

With the exception of your navel and the 1-inch region around it, you can inject corticotropin repository injection anyplace in your upper thigh, upper arm, or stomach area. You can administer corticotropin repository injection anywhere on your upper arm or upper outer thigh if you’re doing a muscle injection. The upper outer thigh is the best place to provide the injection to a baby. Each time you inject the drug, choose a different location at least 1 inch away from the previous one. A tattoo, wart, scar, or birthmark should not be injected into a region that is red, swollen, painful, hard, or sensitive. Avoid injecting the medicine near your knees or groyne.

Before you prepare your dose, have a look at the bottle of corticotropin repository injection. Make sure the vial is labelled with the appropriate drug name and an expiration date that hasn’t already passed. The drug inside the bottle needs to be crystal clear, colourless, and free of any specks or other foreign objects. Call your pharmacist and don’t use that vial if you don’t have the proper drug, it’s expired, or it doesn’t appear right.

Before injecting your drug, let it warm to room temperature. By rubbing the vial between your hands or placing it under your arm for a few minutes, you can warm the drug.

If you are administering a corticotropin repository injection to your child, you can either hold them on your lap or have them lie flat. You might find it useful to have someone else hold the child in place while you administer the medication, or to divert their attention with a noisy toy. By applying an ice cube to the area where you will inject the medication before or after the injection, you might lessen your child’s suffering.

When your kid starts receiving corticotropin repository injection for the treatment of infantile spasms and each time you refill your prescription, your doctor or pharmacist will provide you the manufacturer’s patient information leaflet (Medication Guide). If you have any questions, carefully read the material and contact your doctor or pharmacist. The Medication Guide is also available on the manufacturer’s website or the Food and Drug Administration (FDA) website (

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before using corticotropin repository injection,

  • If you have any allergies, including to corticotropin repository injection, any drugs, any of the chemicals in corticotropin repository injection, or porcine (pig) proteins, let your doctor and pharmacist know right away. For a list of the ingredients, consult the Medication Guide or speak with your pharmacist.
  • Inform your doctor and pharmacist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are currently taking or intend to use. Mention diuretics, also known as “water pills.” Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your doctor if you have scleroderma (an abnormal growth of connective tissue that can lead to tightening and thickening of the skin as well as damage to blood vessels and internal organs), osteoporosis (condition in which the bones become brittle and easily break), a herpes infection in your eye, heart failure, high blood pressure, or any other condition that interferes with the function of your adrenal glands (small glands next to the kidneys) Moreover, let your doctor know if you’ve recently undergone surgery and if you currently have or previously had a stomach ulcer. If your infant will be receiving a corticotropin repository injection, let your doctor know if he or she had an infection before or during delivery. If either you or your kid suffers from one of these illnesses, your doctor could advise against using corticotropin repository injection or administering it to your child.
  • Inform your doctor if you have any type of illness, have any symptoms of an infection such as fever, coughing, vomiting, diarrhoea, or the flu, or if a member of your family has an infection or symptoms of an infection. Moreover, let your doctor know if you have tuberculosis (TB; a serious lung illness), know that you have been exposed to TB, or have ever had a TB skin test that was positive. Additionally, let your doctor know if you have or have ever had liver or kidney disease, diabetes, an underactive thyroid gland, myasthenia gravis (MG), a condition that weakens certain muscles, problems with your stomach or intestines, emotional issues, psychosis (difficulty recognising reality), or any other conditions that affect your nerves or muscles.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Call your doctor if you become pregnant while receiving a corticotropin repository injection.
  • Inform the doctor, dentist, or medical staff that you are using corticotropin repository injection if you need emergency medical treatment, are having surgery, including dental surgery, or are undergoing dental surgery. If you can’t talk in a medical emergency, you should carry a card or wear a bracelet with this information.
  • Avoid getting any shots without first consulting your doctor. Moreover, let your doctor know if any members of your family have immunisation appointments during your treatment.
  • You should be aware that while receiving injections from the corticotropin repository, your blood pressure may rise. Throughout your therapy, your doctor will routinely monitor your blood pressure.
  • You should be aware that administering a corticotropin repository injection could make you more susceptible to infection. During your treatment, be sure to wash your hands frequently and avoid contact with sick people.

What special dietary instructions should I follow?

Your doctor could advise you to eat a diet high in potassium or low in salt. As part of your treatment, your doctor could also advise you to take a potassium supplement. For more information, consult your doctor.

What should I do if I forget a dose?

If you miss a dosage, administer it as soon as you remember. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not provide a second injection.

What side effects can this medication cause?

The injection of corticotropin may have adverse effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Greater or lesser appetite
  • Gaining weight
  • Irritability
  • Alterations in personality or mood
  • Unusually exuberant or cheerful mood
  • Having trouble falling or staying asleep

Certain adverse effects can be very harmful. Call your doctor right away or seek emergency medical attention if you suffer any of these symptoms during or after your treatment:

  • Fever, cough, vomiting, diarrhoea, or other symptoms of illness with a sore throat
  • An open wound or painful
  • Facial thickening or puffiness
  • Increased neck fat but not in the arms or legs
  • Skinny skin
  • Stretch marks on the breasts, thighs, and abdomen
  • Simple bruising
  • Muscular tremor
  • Abdominal pain
  • Vomit that is reddish-colored or resembles coffee grounds
  • Reddish blood in the stools
  • Faeces that is dark or tarry
  • Depression
  • Problem with reality recognition
  • Issues with vision
  • Lot of fatigue
  • Greater thirst
  • Quick heartbeat
  • Rash
  • Enlargement of the throat, lips, tongue, or face
  • Having trouble breathing
  • Distinct or new seizures

Children’s growth and development may be slowed by corticotropin repository injection. The physician for your child will keep a close eye on their development. The dangers of administering this drug to your child should be discussed with your doctor.

Using a corticotropin repository injection may make you more likely to get osteoporosis. During your therapy, your doctor could ask for tests to determine your bone density. Consult your doctor about the potential side effects of this drug as well as steps you can take to reduce your risk of developing osteoporosis.

Further negative effects after corticotropin repository injection are possible. If you experience any strange issues while taking this drug, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. It should be kept in the fridge.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at for additional information.

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your doctor’s appointments. Throughout and after your treatment, your doctor will keep a close eye on your health.

Do not share your medication with anybody else. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • H.P. Acthar Gel®
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