Why is this medication prescribed?

Corticotropin, also known as adrenocorticotropic hormone (ACTH), is a hormone produced by the pituitary gland that stimulates the production of cortisol from the adrenal glands. The repository form of corticotropin is a prolonged-release version designed to have a longer-lasting effect compared to the standard form.

Here are some reasons why repository corticotropin might be prescribed:

• Treatment of Multiple Sclerosis (MS): It’s sometimes used to manage acute exacerbations of MS. The medication can help reduce inflammation and modify the immune response.
• Management of Inflammatory Conditions: Corticotropin may be prescribed for various inflammatory conditions, such as lupus or rheumatoid arthritis, particularly when other treatments haven’t been effective.
• Adrenal Insufficiency: In certain cases, it may be used to diagnose or treat adrenal insufficiency. However, this is less common, as corticosteroids are typically used for this purpose.
• Anti-Inflammatory Effects: Its long-lasting effect makes it useful in conditions requiring sustained anti-inflammatory action.

Repository corticotropin is often chosen when a longer duration of action is desired to manage chronic conditions or when frequent administration of other forms of medication is impractical. However, it’s essential to follow a healthcare provider’s guidance when using this medication, as it can have significant side effects and interactions.

How should this medicine be used?

Corticotropin, Repository Injection, is administered via intramuscular injection. Here’s a general guide on its use:

• Dosage and Administration: The dosage and frequency depend on the condition being treated. The healthcare provider will determine the appropriate dose based on individual needs.
• Injection Site: It is typically injected into the muscle, such as the upper arm or thigh. The exact site may vary based on the patient and provider’s recommendation.
• Preparation: The medication should be prepared and handled according to the manufacturer’s instructions and the healthcare provider’s guidelines.
• Frequency: The frequency of injections varies. For diagnostic purposes, it might be a single dose or a series of doses over a period. For therapeutic use, it might be administered periodically based on the patient’s response and condition.
• Monitoring: Regular monitoring by a healthcare provider is essential to assess the effectiveness and to check for side effects or adverse reactions.
• Handling: It should be stored as directed, usually in a cool, dry place, and should not be used if it appears discolored or if the container is damaged.

Patients should follow their healthcare provider’s instructions precisely and discuss any concerns or side effects experienced during treatment.

Other uses for this medicine

• Certain Autoimmune Disorders: Used to manage conditions like systemic lupus erythematosus or rheumatoid arthritis, where inflammation needs to be controlled.
• Dermatological Conditions: Sometimes used for inflammatory skin disorders.
• Neuroinflammatory Conditions: Employed in conditions like myasthenia gravis to help control symptoms.

What special precautions should I follow?

Special Precautions to Follow:

• Medical History: Inform your healthcare provider about any history of infections, hypertension, diabetes, kidney problems, or mental health issues. These conditions can be affected by corticosteroid treatment.
• Infection Risk: Corticotropin can weaken the immune system. Avoid exposure to infections and notify your doctor if you develop signs of an infection.
• Blood Pressure Monitoring: Regularly monitor blood pressure, as Corticotropin can cause or worsen hypertension.
• Fluid Retention: Watch for symptoms of fluid retention, such as swelling in the hands, feet, or ankles, and report these to your healthcare provider.
• Blood Sugar Levels: If you have diabetes or are at risk of diabetes, monitor your blood sugar levels more frequently, as Corticotropin can affect glucose metabolism.
• Bone Health: Prolonged use can impact bone density, so discuss bone health with your healthcare provider, and consider bone density monitoring if you’re on long-term treatment.
• Mental Health: Report any significant mood changes or psychological effects to your healthcare provider.
• Vaccinations: Avoid live vaccines while on Corticotropin as it can weaken your immune response.
• Drug Interactions: Inform your healthcare provider of all other medications and supplements you are taking to avoid potential interactions.
• Pregnancy and Breastfeeding: Discuss with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding, as Corticotropin may not be recommended during these times.

Always follow the specific instructions given by your healthcare provider and report any unusual symptoms or concerns promptly.

What special dietary instructions should I follow?

• Salt Intake: Corticotropin can cause fluid retention and hypertension. Reducing salt intake can help manage these effects.
• Balanced Diet: Maintain a balanced diet rich in calcium and vitamin D to support bone health, especially if you are on long-term therapy.
• Monitor Blood Sugar: If you have diabetes or are at risk, follow a diet that helps manage blood sugar levels, and monitor them regularly.
• Hydration: Ensure adequate hydration to help manage fluid balance and reduce swelling.

What should I do if I forget a dose?

• Timing: If you remember shortly after the missed dose, take it as soon as possible.
• Skip and Continue: If it’s almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double up on doses to make up for a missed one.
• Consult Healthcare Provider: Always contact your healthcare provider for guidance on what to do if you miss a dose, as they can provide specific instructions based on your treatment plan.
• Record Keeping: Keep a record of missed doses and any actions taken to discuss with your healthcare provider during follow-up appointments.

What side effects can this medication cause?

Corticotropin, Repository Injection can cause various side effects. Some of the common and serious side effects include:

Common Side Effects:

• Swelling: Fluid retention can lead to swelling in the hands, feet, or ankles.
• Weight Gain: Increased appetite and fluid retention can contribute to weight gain.
• Mood Changes: Mood swings, irritability, or depression.
• High Blood Pressure: It can increase blood pressure or exacerbate existing hypertension.
• Headache: Some patients may experience headaches.
• Insomnia: Difficulty sleeping or sleep disturbances.

Serious Side Effects:

• Infections: Increased susceptibility to infections due to immune system suppression.
• Hyperglycemia: Elevated blood sugar levels, which can worsen diabetes or lead to new-onset diabetes.
• Osteoporosis: Long-term use can lead to bone thinning and increased risk of fractures.
• Gastrointestinal Issues: Nausea, vomiting, and abdominal pain.
• Psychiatric Effects: Severe mood swings, hallucinations, or severe depression.
• Muscle Weakness: Prolonged use may lead to muscle weakness or wasting.
• Adrenal Suppression: Long-term use can suppress natural adrenal gland function, leading to adrenal insufficiency.

Rare but Serious Effects:

• Allergic Reactions: Severe allergic reactions, such as rash, itching, or swelling, which may require immediate medical attention.
• Eye Problems: Cataracts or increased intraocular pressure.
• Peptic Ulcers: Risk of developing stomach ulcers or gastrointestinal bleeding.

If you experience any severe or concerning symptoms, contact your healthcare provider immediately. They can provide guidance on managing side effects and adjusting your treatment plan if necessary

What should I know about storage and disposal of this medication?

Storage and Disposal of Corticotropin, Repository Injection:

Storage:

• Temperature: Store the medication according to the manufacturer’s instructions, usually at room temperature (20-25°C or 68-77°F). Check the label for specific temperature requirements.
• Protection: Keep it away from light and moisture.
• Keep Out of Reach: Store it in a secure place out of reach of children and pets.
• Expiration: Do not use the medication past its expiration date. Dispose of it properly if it has expired or if you no longer need it.

Disposal:

• Drug Take-Back Programs: The best way to dispose of unused or expired medication is to take it to a drug take-back program or a designated disposal site. Check with your local pharmacy or waste management services for available options.
• Disposal Instructions: Some medications come with specific disposal instructions on the label. Follow these instructions carefully.
• Avoid Flushing: Do not flush medications down the toilet or sink unless the label or patient information specifically instructs you to do so.

In case of emergency/overdose

• Seek Medical Attention: If you suspect an overdose or experience severe symptoms, seek immediate medical attention or call emergency services.
• Symptoms of Overdose: Symptoms may include severe mood swings, high blood pressure, extreme fluid retention, or unusual physical or psychological symptoms.
• Poison Control: You can also contact your local poison control center for advice on what to do in the event of an overdose.

What other information should I know?

• Regular Monitoring: Regular check-ups with your healthcare provider are essential to monitor for side effects, adjust dosages, and ensure the effectiveness of the treatment.
• Medication Interactions: Inform your healthcare provider about all other medications and supplements you are taking to avoid potential interactions.
• Consistency: Adhere to the prescribed dosage and schedule. Do not alter the dose or frequency without consulting your healthcare provider.
• Allergic Reactions: Be aware of signs of allergic reactions, such as rash, itching, or swelling, and report these immediately to your healthcare provider.
• Lifestyle Adjustments: Follow any lifestyle or dietary recommendations provided by your healthcare provider to manage side effects and support overall health.
• Communication: Keep an open line of communication with your healthcare provider regarding any concerns, side effects, or changes in your health status.

Following these guidelines helps ensure safe and effective use of Corticotropin, Repository Injection and minimizes the risk of complications.