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Concentraid (Generic Desmopressin Nasal)

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Desmopressin nasal may result in severe, potentially fatal hyponatremia (low level of sodium in your blood). Inform your doctor if you have or have ever had kidney disease, syndrome of inappropriate antidiuretic hormone (SIADH; a condition in which the body produces excessive amounts of a natural substance that causes the body to retain water), low sodium levels in your blood, frequent thirst, or excessive fluid consumption. Infections, fevers, and stomach or intestinal illnesses with vomiting or diarrhoea should also be mentioned to your doctor. If you experience any of the following side effects while receiving treatment, let your doctor know right away: headache, nausea, vomiting, restlessness, weight gain, loss of appetite, irritability, fatigue, drowsiness, dizziness, muscle cramping, seizures, confusion, loss of consciousness, or hallucinations.

Inform your physician if you are using a loop diuretic (“water pills”) such as bumetanide, furosemide (Lasix), or torsemide, an inhaled steroid like beclomethasone (Beconase, QNasl, Qvar), budesonide (Pulmicort, Rhinocort, Uceris), fluticasone (Advair, Flonase, Flovent), momet (Rayos). If you take or use one of these drugs, your doctor will likely advise against using desmopressin nasal.

Keep all of your appointments with your physician and the lab. Before and during your therapy, your doctor will request tests to assess your sodium levels in order to see how your body is responding to desmopressin nasal.

Discuss the potential risks of using desmopressin nasal with your doctor.

Why is this medication prescribed?

Desmopressin nasal (DDAVP®) is used to treat the symptoms of a specific kind of diabetes insipidus, sometimes known as “water diabetes,” in which the body generates excessive amounts of urine. Desmopressin nasal (DDAVP®) is also used to treat excessive thirst and abnormally large amounts of urine passing through the body after certain types of surgery or after a head injury. Adults who awaken at least twice a night to urinate can reduce frequent nighttime urine with desmopressin nasal (Noctiva®). Desmopressin nasal (Stimate®) is used to treat specific types of bleeding in patients with certain blood levels of von Willebrand’s disease and haemophilia, a condition in which the blood does not clot correctly. Antidiuretic hormones are a class of drugs that includes desmopressin nasal. It functions by substituting the hormone vasopressin, which the body normally produces to assist balance the amount of salt and water.

How should this medicine be used?

Desmopressin nasal is available as a nasal spray and a liquid that is injected into the nose through a rhinal tube (a tiny plastic tube put in the nose to deliver medication). Typically, it is utilised once to three times per day. One to two sprays of desmopressin nasal (Stimate®) are administered daily to treat haemophilia and von Willebrand’s disease. If Stimate® is used prior to surgery, it is typically administered two hours beforehand. One spray of desmopressin nasal (Noctiva®) is often administered in either the left or right nostril 30 minutes before going to bed to treat frequent nighttime urination. Every day, use desmopressin nasal at around the same time(s). If there is anything you do not understand about the instructions on your prescription label, contact your doctor or pharmacist to clarify it. Just as it is prescribed, use nasal desmopressin. Use only as directed by your doctor, either in the recommended amount or frequency.

There are two different strengths of desmopressin nasal spray (Noctiva). These goods are incompatible with one another. Be sure the correct medication is given to you each time your prescription is filled. Inform your doctor and pharmacist as soon as possible if you believe you were given the incorrect strength.

Depending on your situation, your doctor may start you on a low dose of desmopressin nasal and then adjust it. Pay close attention to these guidelines.

If you intend to use the nasal spray, you should check the manufacturer’s details to determine how many sprays are in your container. Do not count the priming sprays when counting the amount of sprays you use. Even if the bottle still has some medication in it, throw it away after using the recommended number of sprays because additional sprays might not contain the complete recommended dosage. Never attempt to transfer unused medication to a different bottle.

Read the printed directions included with the medication before using desmopressin nasal for the first time. Make sure you know how to use the spray or rhinal tube and how to prepare the bottle before using it for the first time. If you have any concerns about how to take this medication, consult your doctor or pharmacist.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you’re interested in using this drug for any other conditions.

What special precautions should I follow?

Before using desmopressin nasal,

  • If you have any allergies, including to desmopressin, other medicines, or any of the substances in desmopressin nasal spray, let your doctor and pharmacist know right away. Get a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Mention the drugs in the IMPORTANT CAUTION section as well as any of the following: Aspirin, other NSAIDs such ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), carbamazepine (Equetro, Tegretol, Teril), chlorpromazine, and other nasal medicines; thiazide diuretics (also known as “water pills”), such as hydrochlorothiazide (Microzide, many combination products), indapamide, and metolazone (Zaroxolyn); lamotrigine (Lamictal); narcotic (opiate) painkillers; selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro); or tricyclic antidepressants, also known as “mood elevators,” including amitriptyline, desipramine (Norpramin), doxepin (Silenor), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil). Your doctor might need to adjust your medication doses or keep a close eye out for any negative side effects.
  • If you have or have ever had heart failure, high blood pressure, or cardiac disease, let your doctor know. Most likely, your doctor will advise against using desmopressin nasal.
  • Inform your physician if you have or have ever had cystic fibrosis or urinary retention (an inborn disease that causes problems with breathing, digestion, and reproduction). Moreover, let your doctor know if you have recently undergone head or facial surgery, have a runny or congested nose, scars or swelling inside your nose, or have atrophic rhinitis (condition in which the lining of the nose shrinks and the inside of the nose becomes filled with dry crusts). At any point during your therapy, if your nose starts to feel stuffed or runny, call your doctor.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Call your doctor if you become pregnant while taking desmopressin.

What special dietary instructions should I follow?

During your desmopressin medication, your doctor might advise you to reduce the quantity of liquids you consume, especially in the evening. To avoid significant side effects, strictly follow your doctor’s instructions.

What should I do if I forget a dose?

If you are using desmopressin nasal (DDAVP®) or (Stimate®) and forget to take a dose, take it right away. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

When taking desmopressin nasal (Noctiva®), if you miss a dose, skip it and take the subsequent dose at the scheduled time. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

Desmopressin nasal side effects are possible. If any of the following symptoms are severe or do not go away, contact your doctor right once:

  • Abdominal pain
  • Heartburn
  • Weakness
  • Having trouble falling or staying asleep
  • Warm sensation
  • Nosebleed
  • Nostril discomfort or obstruction
  • Itchiness or light sensitivity
  • Back ache
  • Chills, a cough, a sore throat, or other symptoms of infection
  • Flushing

There could be some severe negative effects. Call your doctor right away if you suffer any of the following symptoms or those detailed in the IMPORTANT CAUTION section:

  • Vomiting
  • Chest pain
  • Rapid or hammering heartbeat
  • Rash
  • Hives
  • Itching
  • Breathing or swallowing challenges

Further adverse effects of desmopressin nasal are possible. If you have any strange side effects while taking this medicine, let your doctor know.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep the nasal sprays securely closed in the container they came in and away from minors.

Stimate® nasal spray should be kept upright and kept at a temperature of no more than 25°C. After six months, it should be thrown away.

DDAVP® nasal spray should be stored upright at 20 to 25°C. Keep DDAVP® rhinal tubes at 2 to 8°C; closed bottles remain stable at 20 to 25°C for 3 weeks.

Store Noctiva® nasal spray upright at 2 to 8°C before opening. Once Noctiva® has been opened, store it upright at a temperature of 20 to 25°C; after 60 days, throw it away.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at for additional information.

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Symptoms of overdose may include:

  • Confusion
  • Drowsiness
  • Headache
  • Having trouble urinating
  • Unexpected weight gain
  • Seizures

What other information should I know?

Do not share your medication with anybody else. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Concentraid®
  • DDAVP® Nasal
  • Minirin® Nasal
  • Noctiva® Nasal
  • Stimate® Nasal
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