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Cometriq (Generic Cabozantinib)

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Why is this medication prescribed?

A variety of disorders are treated with cabozantinib (Cabometyx, Cometriq).

Cabozantinib (Cabometyx) is used:

  • Advanced renal cell carcinoma treatment (RCC; a type of cancer that begins in the cells of the kidneys).
  • In individuals with advanced RCC who have not yet had RCC treatment in conjunction with nivolumab (Opdivo).
  • To treat patients who had previously received sorafenib for hepatocellular carcinoma (HCC; a form of liver cancer) (Nexafar).
  • To treat a specific type of thyroid cancer that has spread to neighbouring tissues or other parts of the body, has not responded to prior treatments, and cannot be treated with radioactive iodine in adults and children 12 years of age and older.

Cabozantinib (Cometriq) is used:

  • To treat a specific kind of thyroid cancer that is worsening and has spread to other body parts.

Kinase inhibitors are a class of drugs that includes cabozantinib. It functions by preventing the action of a problematic protein that instructs cancer cells to proliferate. This aids in containing or halting the spread of cancer cells.

How should this medicine be used?

The oral dosage forms of cabozantinib are a tablet (Cabometyx) and a capsule (Cometriq). On an empty stomach, at least 1 hour before and 2 hours after eating, it is typically taken once daily. Take cabozantinib every day at roughly the same time. The effectiveness of the drug on your body and any adverse effects you encounter will determine how long you need to receive treatment. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Follow the medication’s directions precisely. Never take it in larger or less amounts or more frequently than directed by your doctor.

Take the tablets and capsules whole, along with a full glass of water (8 ounces/240 mL). Do not eat, split, open, or crush them.

If you develop severe adverse effects, your doctor may lower your cabozantinib dosage or temporarily or permanently stop your therapy. During your cabozantinib treatment, be sure to discuss your feelings with your doctor.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking cabozantinib,

  • If you have any allergies, including to cabozantinib (Cabometyx, Cometriq), other medicines, or any of the substances in cabozantinib tablets or capsules, notify your doctor right away. For a list of the ingredients, consult the Medication Guide or speak with your pharmacist.
  • Inform your doctor and pharmacist about all prescription and over-the-counter drugs, vitamins, and dietary supplements you are currently taking or intend to take. Incorporate any of the following: Atazanavir (Reyataz), adefovir (Hepsera), abacavir (Ziagen, in Epzicom, in Triumeq), carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), cidofovir, clarithromycin (Biaxin), furosemide (Lasix), and itraconazole are some examples of medications (Sporanox, Tolsura), ketoconazole, lamivudine (Epivir, in Combivir, in Symfi, among others), nelfinavir (Viracept), nevirapine (Viramune), phenobarbital, phenytoin (Dilantin, Phenytek), probenecid (Probalan), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane (Coumadin, Jantoven). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects. Tell your doctor about all the drugs you are taking, including any not on this list, as many other drugs may also interact with cabozantinib.
  • Please let your doctor know if you are taking any herbal supplements, especially St. John’s wort.
  • Tell your doctor if you’ve experienced any unusual or severe bleeding recently, such as bloody or black tarry stools, bloody or vomiting, or coughing up blood. Moreover, let your doctor know if you have an open or healed wound, a low blood calcium level, thyroid issues, high blood pressure, or liver illness.
  • If you are pregnant or plan to become pregnant, let your doctor know. Before beginning cabozantinib therapy, you must get a pregnancy test. Throughout your therapy and for four months following your last dose, you shouldn’t get pregnant. See your physician about birth control options you can take while undergoing therapy. Call your doctor right away if you become pregnant while taking cabozantinib. The foetus could suffer from capazantinib.
  • Describe to your doctor if you are nursing a baby. During therapy and for four months following your last dose, your doctor might advise against breastfeeding.
  • You should be aware that this medicine may lower both male and female fertility. You should discuss the dangers of taking cabozantinib with your doctor.
  • Inform the surgeon that you are taking cabozantinib if you are having surgery. Your doctor will likely instruct you to cease taking cabozantinib at least 21 days prior to your operation or surgery and will specify when you should begin doing so.
  • You need to be aware that cabozantinib may seriously harm your jaw. Before beginning to take cabozantinib and on a regular basis while undergoing therapy, you should get a dental exam. While using cabozantinib, make sure to thoroughly brush your teeth and clean your mouth. Before getting any dental work done while taking this medication, see your doctor. Most likely, your physician would advise you to stop taking cabozantinib at least 21 days prior to dental surgery.
  • You should be aware that while taking cabozantinib, your blood pressure may rise. Your blood pressure will likely be checked both before and throughout therapy by your doctor.

What special dietary instructions should I follow?

While using this medication, avoid consuming grapefruit, grapefruit juice, or any other foods, supplements, or grapefruit products.

What should I do if I forget a dose?

If you miss a dosage, take it as soon as you recall. Nevertheless, omit the missed dose and go on with your regular dosing schedule if there are less than 12 hours until your next scheduled dose. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

Cabozantinib could have unwanted effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Constipation
  • Nausea
  • Vomiting
  • Having trouble swallowing
  • Alterations in food taste
  • Haemorrhoids
  • Inflammation, blisters, or discomfort in your mouth or throat
  • Reduced appetite
  • Slim down
  • Anxiety
  • Weakness or fatigue
  • Light skin
  • Arid skin
  • Skin that has thickened in patches
  • Pain in the arms, legs, or joints
  • Alteration or hoarseness of voice
  • Hair fall
  • Greying or lightening of the hair
  • Slow healing of wounds

Some adverse effects may be severe. Call your doctor right away or seek emergency medical attention if you have any of these symptoms:

  • Stiffness or pressure in the chest
  • Blood or blood clots being coughed up
  • Vomiting bloody or coffee-ground-looking stuff
  • Thicker than normal menstrual bleeding
  • Black or crimson, tarry stool
  • Bloody nose
  • Diarrhoea
  • Unusually severe bruising or bleeding
  • Uncomfortable or sensitive abdominal area
  • Edoema of the ankles, eyes, hands, arms, legs, and/or feet
  • Frothing urine
  • Coughing or breathing difficulties
  • Difficulty breathing
  • Hammering, rapid, or erratic heartbeat
  • Acutely painful headache
  • Feeling dizzy or faint
  • Seizures
  • One side of your body may have numbness or weakness in the face, arm, or leg.
  • Sudden difficulty walking
  • Abrupt issues with vision
  • Confusion
  • Abruptly having trouble speaking or thinking coherently
  • Abrupt balancing or coordination challenges
  • Dizziness
  • More perspiration than usual
  • Jaw ache
  • Toothache
  • Teeth slipping out of place
  • Uncomfortable or swollen gums
  • Rash
  • The soles or palms of the hands developing redness, discomfort, swelling, or blisters
  • Severe exhaustion, lightheadedness, dizziness, weakness, nausea, or vomiting
  • Extreme fatigue, easy bruising or bleeding, a yellowing of the skin or eyes, stomach pain in the right side, dark urine, and diminished appetite
  • Muscular spasms or stiffness
  • Unexpected weight gain
  • Tingling, burning, or numbness in the lips, feet, arms, or hands

Further negative effects of capazantinib are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Keep it away from excessive heat and moisture at room temperature (not in the bathroom).

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  • Loss of memory
  • Confusion
  • Slim down

What other information should I know?

Keep all of your appointments with your physician and the lab. To monitor how your body is responding to cabozantinib, your doctor may request specific lab tests.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Cabometyx®
  • Cometriq®
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