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Climara (Generic Estradiol Transdermal Patch)

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WARNING

Estradiol raises your risk of getting endometrial cancer (cancer of the lining of the uterus [womb]). The chance of developing endometrial cancer increases with the duration of estradiol use. You should be prescribed a progestin in addition to transdermal estradiol if you have not had a hysterectomy, a procedure to remove the uterus. The risk of having endometrial cancer may be reduced, but your risk of acquiring certain other health issues, such as breast cancer, may increase. Inform your doctor if you have or have ever had cancer as well as if you experience irregular vaginal bleeding prior to starting to use transdermal estradiol. If you experience irregular or unusual vaginal bleeding while receiving transdermal estradiol, call your doctor right once. To assist ensure that you do not develop endometrial cancer during or after your treatment, your doctor will regularly monitor you.

Women who combined oral oestrogens (a class of drugs that includes estradiol) and progestins had an increased risk of heart attacks, strokes, blood clots in the lungs or legs, breast cancer, and dementia, according to a big study (loss of ability to think, learn, and understand). These disorders may also be more likely to affect women who take transdermal estradiol either alone or in combination with progestins. Inform your doctor if you smoke or use tobacco, if you’ve ever had a heart attack or stroke, if anybody in your family has ever had breast cancer, or if you’ve ever had a blood clot. Additionally, let your physician know if you have ever experienced breast lumps, an abnormal mammogram, high blood pressure, high cholesterol or fat levels, diabetes, heart disease, lupus (a condition in which the body attacks its own tissues, causing damage and swelling), high blood sugar, or high blood pressure (x-ray of the breast used to find breast cancer).

The major medical disorders mentioned above can present with any of the symptoms below. If you suffer any of the following signs while using transdermal estradiol, call your doctor right away: Speech difficulties, dizziness or faintness, sudden complete or partial vision loss, double vision, numbness or weakness in one arm or leg, crushing chest pain or chest heaviness, coughing up blood, sudden shortness of breath, trouble thinking clearly, remembering, or learning new things, breast lumps or other breast changes, discharge from nipples, or pain, tenderness, or redness in one leg are all symptoms of a sudden severe headache, vomiting, and headache of equal severity.

You can take precautions to lessen your chance of experiencing a significant health issue when using transdermal estradiol. Transdermal estradiol should not be used to prevent dementia, heart disease, heart attacks, or strokes on its own or in combination with a progestin. Take transdermal estradiol only as long as necessary and at the lowest dose necessary to control your symptoms. To determine if you should use a lower dose of transdermal estradiol or cease using the medicine, consult your doctor every three to six months.

To help find breast cancer as early as possible, you should check your breasts monthly and get a mammography and breast exam conducted by a doctor once a year. If you have a personal or family history of illness, your doctor will advise you on how to properly inspect your breasts and whether you need to have them checked more frequently than once a year.

If you are having surgery or will be put on bed rest, let your doctor know. In order to reduce your risk of developing blood clots, your doctor may advise you to stop using transdermal estradiol 4–6 weeks prior to the procedure or place you on bedrest.

Regularly discuss the advantages and disadvantages of transdermal estradiol use with your doctor.

Why is this medication prescribed?

In women going through menopause, transdermal estradiol (Climara, Minivelle, Vivelle-Dot) is used to treat hot flashes (also known as hot flushes, which are abrupt feelings of mild to extreme body heat) (change of life; the end of monthly menstrual periods). In addition, vaginal dryness, itchiness, and burning in menopausal women are treated with transdermal estradiol (Climara, Vivelle-Dot). In addition, women going through or recently coming out of menopause can utilise transdermal estradiol (Climara, Menostar, Minivelle, Vivelle-Dot) to prevent osteoporosis, a disorder in which the bones become brittle and brittle and break easily. When a woman has not yet reached menopause and does not naturally make enough oestrogen, she may also utilise transdermal estradiol (Climara, Vivelle-Dot) as a supply of oestrogen. Women who simply experience vaginal dryness, irritation, or burning may find that an oestrogen product given topically to the vagina is more beneficial. A alternative drug without oestrogen may be more advantageous for women who simply need a prescription to prevent osteoporosis. Estradiol belongs to the group of drugs known as oestrogen hormones. It functions by substituting the body’s natural production of oestrogen.

How should this medicine be used?

The skin-applying patch form of transdermal estradiol is available. Depending on the type of patch being used, transdermal estradiol is often applied once or twice a week. While some women wear patches continuously, others alternate 3 weeks of wearing them with 1 week off. On the same day(s) of the week each week, always apply your transdermal patch. On the inside flap of your prescription box, there can be a calendar where you can record when you replace your patch. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Transdermal estradiol should be applied exactly as prescribed. Apply the patches only as directed by your doctor, not more frequently or less often.

Transdermal estradiol will likely be prescribed to you at a modest dosage by your doctor, with the possibility of an increase if your symptoms continue to be troublesome. Your doctor will explain how to switch from the oestrogen medicine you are taking or using to transdermal estradiol if you are currently taking or using one. Make sure you comprehend these directions. Consult your doctor about the effectiveness of transdermal estradiol for you.

Estradiol patches should be applied to cold, dry, clean skin in the lower abdomen, below the waist. Moreover, the upper buttocks can receive some types of patches. To determine the optimum location(s) to apply the brand of patches you have received, speak with your doctor or pharmacist or read the manufacturer’s instructions included with your patches. Applying estradiol patches to the breasts or to skin that is greasy, inflamed, cut, or injured is not advised. Applying tight clothing may rub estradiol patches off at the waistline, and sitting may rub them off at the lower buttocks, so avoid doing so. Be sure there are no lotions, creams, or powders on the skin in the area where you intend to apply an estradiol patch. Wait at least a week after putting one patch to a specific location before applying another.

If you’re using an estradiol transdermal patch, ask your doctor or pharmacist if you need to be cautious when bathing, showering, or using a sauna. You can also read the manufacturer’s advice that came with your prescription. While some patch brands may loosen as a result of these activities, others are less likely to be harmed.

If you’re using an estradiol transdermal patch, ask your doctor or pharmacist if you need to be cautious when bathing, showering, or using a sauna. You can also read the manufacturer’s advice that came with your prescription. While some patch brands may loosen as a result of these activities, others are less likely to be harmed.

Each brand of transdermal estradiol patch should be placed in accordance with the detailed instructions provided in the patient’s information provided by the manufacturer. Before using estradiol transdermal and each time you get a refill on your prescription, carefully read the following instructions. If you have any inquiries, speak with your physician or pharmacist. When using any kind of transdermal estradiol patch, the general instructions listed below can help you keep in mind a few key steps.

  1. Pull the pouch apart with your fingertips. Avoid using scissors as they could harm the patch. Wait until you are prepared to apply the patch before opening the pouch.
  2. From the pouch, remove the patch. To keep the patch dry within the pouch, there may be a silver foil sticker present. This sticker should remain in the pouch.
  3. Press the patch’s sticky side against your skin in the location you’ve chosen to wear it by removing the patch’s protective lining. A liner on some patches is designed to come out in two sections. If your patch has that kind of liner, you should peel back a portion of it and press the patch’s exposed skin with that side. The second side of the patch should now be pressed against your skin after you have folded back the first side and peeled off the remaining liner. Avoid touching the adhesive side of the patch with your fingers at all times.
  4. For 10 seconds, apply pressure to the patch with your fingers or palm. Make sure the patch is properly adhered to your skin, paying particular attention to the patch’s edges.
  5. Wear the patch constantly until it’s time to take it off. When it’s time to take off the patch, peel it off your skin gradually. The patch should be disposed of safely, out of the reach of children and animals, by folding it in half and pressing the sticky sides together.
  6. After removing the patch, if a sticky substance is still on your skin, you should wait 15 minutes before using an oil or lotion to get it off.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before using transdermal estradiol,

  • If you have an allergy to any transdermal estradiol brand, any other oestrogen products, any drugs, any adhesives, or any of the substances in estradiol transdermal patches, let your doctor and pharmacist know right away. Get a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any prescription and over-the-counter drugs, vitamins, and dietary supplements you are currently taking or intend to take. Mention any of the following medications: phenobarbital, carbamazepine (Carbatrol, Epitol, Tegretol, and others), clarithromycin, erythromycin (E.E.S., Eryc, Ery-Tab), itraconazole (Sporanox, Tolsura), ketoconazole, other estrogen-containing pharmaceuticals, rifampin (Rifadin, Rimactane), r (Levoxyl, Synthroid, Tirosint). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects. Tell your doctor about all the drugs you are taking, even those not on this list, as many other drugs may also interact with estradiol transdermal patches.
  • Please let your doctor know if you are taking any herbal supplements, especially St. John’s wort.
  • If you have or have previously had a bleeding condition, let your doctor know; asthma, seizures, migraine headaches, endometriosis (a condition in which the tissue that lines the uterus [womb] grows in other areas of the body), uterine fibroids (growths in the uterus that are not cancer), yellowing of the skin or eyes, particularly during pregnancy or while you were using an oestrogen product, very high or very low levels of calcium in your blood; Angioedema (a condition that causes hives, breathing problems, and painful swelling of the face, lips, throat, tongue, hands, or feet); porphyria (condition in which abnormal substances build up in the blood and cause problems with the skin or nervous system); or gallbladder, thyroid, pancreas, liver, or kidney disease.
  • Inform your doctor if you are nursing a baby or want to become pregnant. Call your doctor if you become pregnant while using transdermal estradiol.
  • Ask your doctor about other methods of preventing the condition, such as exercising and taking calcium and/or vitamin D supplements, if you are using transdermal estradiol to prevent osteoporosis.

What special dietary instructions should I follow?

If you plan to consume grapefruits or grapefruit juice while taking this medication, consult your doctor.

How can I improve my intake of calcium and vitamin D? Discuss with your doctor.

What should I do if I forget a dose?

As soon as you remember, apply the forgotten patch. then proceed to apply the following patch in the usual manner. Applying multiple patches to make up for a missing patch is not advised.

What side effects can this medication cause?

Side effects from transdermal estradiol are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Headache
  • Achy or sensitive breasts
  • Nausea
  • Vomiting
  • Constipation
  • Gas
  • Heartburn
  • Loss or increase of weight
  • Hair fall
  • Inflammation or redness of the skin under the estradiol patch
  • Vaginal edoema, redness, stinging, itchiness, or irritation
  • Discharge from the cervix
  • Gruelling menstrual cycles
  • Anxiety
  • Depression
  • Variations in mood
  • Alterations in sexual drive
  • Muscular, neck, or back ache
  • Nose bleeds or congestion
  • Darkening of the face’s skin (may not go away even after you stop using transdermal estradiol)
  • Excessive hair growth
  • Using contact lenses is challenging
  • Joints hurt

Some adverse effects may be severe. Call your doctor right away if you have any of the following symptoms or any of the ones detailed in the IMPORTANT CAUTION section:

  • Eyes or skin that have a yellow tint
  • Reduced appetite
  • Fever
  • Stomach ache, agony, or tenderness
  • Itching
  • Hives
  • Rash, skin blisters, or other skin modifications
  • Edoema of the lower legs, hands, feet, ankles, tongue, throat, eyes, face, lips, and/or throat
  • Hoarseness
  • Breathing or swallowing challenges

Your chance of getting gallbladder disease and ovarian cancer, both of which may require surgery to address, may increase if you use transdermal estradiol. Discuss the dangers of using transdermal estradiol with your doctor.

Children who utilise high dosages of transdermal estradiol for an extended period of time may experience slowed or early growth. When your kid receives transdermal estradiol medication, her doctor will keep a close eye on her progress. The hazards of giving your child this medication should be discussed with your child’s doctor.

Further negative effects of transdermal estradiol are possible. If you experience any strange issues while taking this drug, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep estradiol patches away from children and tightly wrapped in their original pouches. Keep the patches away from excessive heat and moisture at room temperature (not in the bathroom).

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at http://goo.gl/c4Rm4p for additional information.

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning. http://www.upandaway.org

In case of emergency/overdose

Too much oestrogen may be absorbed into your system if you apply patches too frequently or for too long. You might then encounter signs of an overdose.

Remove the skin patches in the event of an overdose, then dial 1-800-222-1222 to reach your local poison control centre. Moreover, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose symptoms could include:

  • Nausea
  • Vomiting
  • Uterine bleeding
  • Breast sensitivity
  • Abdomen ache
  • Sluggishness or exhaustion

What other information should I know?

Keep all of your appointments with your physician and the lab. At least once every year, you should get a full physical assessment, which should include a pelvic exam. To monitor your body’s reaction to transdermal estradiol, your doctor could request specific lab tests.

Inform the lab staff and your doctor that you are using transdermal estradiol prior to any laboratory test.

Do not share your medication with anybody else. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Alora®
  • Climara®
  • Esclim®
  • Estraderm®
  • FemPatch®
  • Menostar®
  • Minivelle®
  • Vivelle®
  • Vivelle-Dot®
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