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Cis-Platinum II (Generic Cisplatin Injection)

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Cisplatin injection must be administered in a hospital or other healthcare institution under the direction of a physician with training in administering chemotherapy drugs for cancer.

Cisplatin may seriously damage renal function. Older persons may experience kidney issues more frequently. Your doctor will request laboratory testing before and during your therapy to check if your kidneys are damaged by this drug. If you have renal illness now or ever have, let your doctor know. If you take aminoglycoside antibiotics such tobramycin, gentamicin, or amikacin (Amikin), let your doctor and pharmacist know (Tobi, Nebcin). Call your doctor right away if you have any of the following symptoms: reduced urination, face, arm, hand, foot, ankle, or lower leg edoema, unusual fatigue, or weakness.

Particularly in children, cisplatin has the potential to seriously impair hearing. Hearing loss may be permanent in some circumstances. Before and after your treatment, your doctor will conduct tests to check on your hearing. If you have ever undergone head radiation therapy, tell your doctor and pharmacist. If you take aminoglycoside antibiotics such tobramycin, gentamicin, or amikacin (Amikin), let your doctor and pharmacist know (Tobi, Nebcin). Dial your doctor right once if you develop any of the following signs: hearing loss, ringing in the ears, or dizziness.

If you have already gotten multiple injections of cisplatin, you may experience severe adverse responses. If you develop an allergic reaction to cisplatin injection, it may occur within a few minutes after your infusion starts, and you may experience the following symptoms: Hives, skin rashes, itching, skin reddening, breathing or swallowing issues, swelling of the face, throat, tongue, or lips, feeling faint or dizzy, or a rapid heartbeat. In the event that you suffer any of these signs, contact your doctor right once.

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to cisplatin, your doctor will prescribe specific tests prior to, during, and after your treatment. Your doctor may need to stop or delay your treatment if you experience certain side effects.

Why is this medication prescribed?

After receiving treatment with other drugs or radiation therapy, testicular cancer that has not improved or worsened is treated with cisplatin in combination with other drugs. To treat cancer of the ovaries (cancer that starts in the female reproductive organs where eggs are created) that has not improved or that has gotten worse after treatment with other drugs or radiation therapy, cisplatin is used alone or in combination with other treatments. When surgery or radiation therapy are ineffective for treating bladder cancer, cisplatin may be administered alone or in conjunction with other drugs. The group of drugs known as platinum-containing compounds includes cisplatin. It functions by inhibiting or reducing the development of cancer cells.

How should this medicine be used?

A doctor or nurse will administer cisplatin injection intravenously (into a vein) over the course of 6 to 8 hours in a medical setting. Usually, it is administered once every three to four weeks.

Other uses for this medicine

Lung cancer, cervical and esophageal cancer, brain tumours, malignant pleural mesothelioma (cancer in the lining of the chest or abdomen), neuroblastoma, and head and neck cancer are other conditions that can be treated with cisplatin (a cancer that begins in nerve cells and occurs mainly in children). The dangers of using this medicine for your illness should be discussed with your doctor.

Ask your doctor or pharmacist for more details if you believe this drug may be recommended for another purpose.

What special precautions should I follow?

Before taking cisplatin,

  • If you have an allergy to cisplatin, carboplatin (Paraplatin), any other drugs, or any of the chemicals in cisplatin injection, let your doctor and pharmacist know right once. Contact your pharmacist for a list of the ingredients.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Include any of the following medications as well: amphotericin B (Abelcet, AmBisome, Amphotec, Fungizone Intravenous), anticonvulsants like phenytoin (Dilantin), bumetanide (Bumex), ethacrynic acid (Edecrin), furosemide (Lasix), pyridoxine, as well as any others not listed in the IMPORTANT WARNING section (Vitamin B-6). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects. Tell your doctor about all of the medications you are taking, including those that do not appear on this list, as many other drugs may also interact with cisplatin.
  • If you have kidney illness or hearing issues, let your doctor know. The injection of cisplatin might not be recommended by your doctor.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. While getting cisplatin, you shouldn’t get pregnant or breastfeed. Call your doctor if you fall pregnant while taking cisplatin. The foetus could suffer from cisplatin.

What side effects can this medication cause?

Cisplatin could have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Nausea
  • Vomiting
  • Diarrhea
  • Hair fall
  • Deterioration of food taste
  • Hiccups
  • Dehydration symptoms including a dry mouth, dark urine, less sweating, dry skin, and others

Certain adverse effects can be very harmful. Call your doctor right away if you have any of these signs or any of those in the IMPORTANT CAUTION section:

  • Pain, redness, stinging, or swelling at the injection site
  • Hands or feet tingling, burning, or pain
  • Muscular pain
  • Having trouble walking
  • Shock-like electric sensation when you incline your neck forward
  • Seizures
  • Abrupt alterations in eyesight, including colour perception
  • Absence of vision
  • Eye discomfort
  • Chest pressure or pain
  • Fever, chills, a sore throat, or other symptoms of infection
  • Uncommon bruising or bleeding
  • Stool that is dark and tarry
  • Bench with a reddish tint
  • Tainted vomit
  • Vomited substance that resembles coffee grounds

Cisplatin may make you more likely to get other cancers. The dangers of using this drug should be discussed with your doctor.

Further negative effects of cisplatin are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Symptoms of overdose may include:

  • Less urinations
  • Edoema of the lower legs, lower arms, hands, feet, ankles, or face
  • Unexpected fatigue or weakened state
  • Taking or
  • Stomach ache in the top right corner
  • Nausea
  • Vomiting
  • Uncommon bruising or bleeding
  • Hearing issues
  • Abrupt alterations in eyesight
  • Fever, chills, a sore throat, or other symptoms of infection
  • Hands or foot pain, burning, numbness, or tingling

What other information should I know?

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Platinol®
  • Platinol-AQ®
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