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Cinryze (Generic C1-Esterase Inhibitor Human Injection)

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Why is this medication prescribed?

Hereditary angioedema (HAE; an inherited disorder that produces episodes of swelling in the hands, feet, face, airway, or intestines) is treated with C1-esterase inhibitor human injectable (Cinryze, Haegarda) in adults and children older than 6 years old to prevent swelling and uncomfortable attacks. Adults and children with symptoms affecting the stomach, intestines, face, throat, and airway are treated for acute bouts of hereditary angioedema with the C1-esterase inhibitor human injectable (Berinert). Complement inhibitors are a group of drugs that includes C1-esterase inhibitor human. It functions by substituting the body’s natural C1-esterase inhibitor, which reduces edoema and inflammation.

How should this medicine be used?

Human C1-esterase Inhibitor (Haegarda) is available as a powder in a vial that must be combined with a liquid for subcutaneous injection (under the skin). Human C1-esterase Inhibitor (Berinert, Cinryze) is available as a powder in a vial that must be combined with a liquid for intravenous injection (into a vein). C1-esterase inhibitor human injection is often given intravenously (Cinryze) for a period of 5 to 10 minutes or subcutaneously (Haegarda) every 3 to 4 days to prevent swelling and excruciating attacks of hereditary angioedema. When necessary, C1-esterase inhibitor human injection (Berinert) is typically given intravenously for the treatment of acute bouts of hereditary angioedema. Follow your doctor’s instructions. If there is anything you do not understand about the instructions on your prescription label, contact your doctor or pharmacist to clarify it. Administer the human C1-esterase inhibitor injection exactly as instructed. Use the dosage exactly as directed by your doctor and don’t go over or under that amount.

Your doctor may recommend that you or a carer administer your C1-esterase inhibitor human injections at home, but he or she is also free to do so. Your healthcare practitioner will demonstrate to you or a carer how to mix and administer a dosage of C1-esterase inhibitor human injectable if you use it at home. You should read the manufacturer’s information for the patient included with C1-esterase inhibitor human injection before using it for the first time, as should the person administering the injections. These directions explain how to combine and administer a dose of human C1-esterase inhibitor. Make sure you comprehend these instructions. If you have any concerns about mixing or injecting the drug, or about how to get rid of used needles and syringes after you inject the medication, consult your healthcare professional.

The drug should be mixed just before you intend to inject it. To use the medication, however, you must mix it beforehand, keep it at room temperature, and do so either within 8 hours (Berinert, Haegarda), or within 3 hours (Cinryze). Before injecting the drug, make sure it is at room temperature.

Use an injection to administer C1-esterase inhibitor human (Haegarda) under the skin of your stomach. Avoid injecting C1-esterase inhibitor human (Haegarda) into the navel or any other regions of the body where the skin is scarred, inflamed, irritated, itchy, painful, or bruised. Also, avoid injecting in stretch marks or scarred areas. For every injection, pick a different spot that is at least 2 inches distant from the one you used before.

You should contact your doctor right away or seek treatment at a healthcare institution if you are using C1-esterase inhibitor human (Berinert) to treat an acute attack of hereditary angioedema. See your doctor about what to do if you get an acute episode of hereditary angioedema if you are using the C1-esterase inhibitor human (Cinryze, Haegarda) to prevent swelling and uncomfortable attacks of the condition.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before using C1-esterase inhibitor human injection,

  • If you have an allergy to C1-esterase inhibitor human, any other C1-esterase inhibitor products, any other medications, or any of the substances in C1-esterase inhibitor human injectable goods, inform your doctor and pharmacist right away. Get a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Mention any of the following: estrogen-containing drugs, androgens like danazol, methyltestosterone (Android 25), or testosterone (Androderm, Jatenzo, Natesto, among others) (including birth control pills). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your doctor if you have an indwelling catheter, which is a flexible plastic tube inserted into the bladder to drain urine, or if you have been bedridden or confined to a wheelchair for a prolonged period of time. Tell your doctor if you have heart disease, blood clots in your legs, lungs, eyes, brain, or anyplace else on your body, as well as atherosclerosis (the narrowing of blood vessels due to fatty deposits), a stroke, or any of these conditions.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Call your doctor if you get pregnant while using C1-esterase inhibitor human injectable.
  • Inform your doctor or dentist that you are using C1-esterase inhibitor human injectable if you are undergoing surgery or will be on bed rest.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What side effects can this medication cause?

The human injection of a C1-esterase inhibitor may have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Headache
  • Nausea
  • Vomiting
  • An unpleasant aftertaste
  • Cold or fever
  • Discomfort or redness at the injection site
  • Sore throat, watery eyes, a runny nose, or sneezing
  • Dizziness

Certain adverse effects can be very harmful. Call your doctor right away if you develop any of these symptoms, or seek emergency medical attention:

  • Sweating, hoarseness, lightheadedness, or fainting; hives; rash; itching; difficulty breathing or swallowing; blue lips and skin; swelling of your face,
  • Tongue, or throat
  • Warming, discomfort, discolouration, or swelling in a single arm or leg
  • Quick heartbeat
  • Chest ache
  • Breathing difficulty
  • Bodily weakness or numbness on one side

Human C1-esterase inhibitor may have additional negative consequences. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly wrapped, away from children, and in the original container it came in. Unmixed pharmaceutical vials should be kept at room temperature or in the refrigerator away from excess heat and moisture (not in the bathroom). Use medication that has been mixed within 8 hours (Berinert, Haegarda) or 3 hours after storing it at room temperature (Cinryze). Keep the drug from freezing.

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning. 

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose symptoms could include:

  • Warming, discomfort, discolouration, or swelling in a single arm or leg
  • Chest ache
  • Breathing difficul

What other information should I know?

Keep all of your appointments with your physician and the lab.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Berinert®
  • Cinryze®
  • Haegarda®
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