WARNING

Taking Cilostazol carries certain risks, which include:

• Cardiovascular Effects: Cilostazol can cause palpitations (rapid or irregular heartbeat) and exacerbate existing heart conditions.
• Bleeding Risk: Due to its antiplatelet effects, Cilostazol increases the risk of bleeding, particularly in patients with a history of bleeding disorders or those taking other blood-thinning medications.
• Adverse Reactions: Common side effects include headache, diarrhea, dizziness, and peripheral edema (swelling of the legs or ankles).
• Liver Effects: Cilostazol can affect liver function and should be used cautiously in patients with liver impairment.
• Other Precautions: It’s important to monitor for any signs of allergic reactions, severe dizziness, or difficulty breathing, which could indicate a serious adverse event.

Patients should be monitored regularly by their healthcare provider to manage these risks effectively while using Cilostazol for the treatment of intermittent claudication or other approved conditions.

Why is this medication prescribed?

Cilostazol is prescribed primarily to improve the symptoms of intermittent claudication, a condition characterized by pain or cramping in the legs due to reduced blood flow. It belongs to a class of medications called phosphodiesterase inhibitors.

How should this medicine be used?

Here’s how Cilostazol is typically used:

• Dosage: The usual recommended dose is 100 mg taken orally twice daily, at least 30 minutes before or 2 hours after breakfast and dinner.
• Administration: Cilostazol tablets should be swallowed whole with a full glass of water.
• Timing: It’s important to take Cilostazol exactly as prescribed by your doctor. Do not change the dosage or frequency without consulting your healthcare provider.
• Duration: Treatment with Cilostazol is often long-term, as it helps improve circulation and reduce symptoms over time. Your doctor will determine the duration based on your individual condition.
• Monitoring: Regular follow-up visits with your healthcare provider are important to monitor the effectiveness of the medication and any potential side effects.
• Precautions: It’s essential to inform your doctor about any other medications you are taking, including over-the-counter drugs and supplements, to avoid potential interactions.

Always follow your doctor’s instructions carefully regarding the use of Cilostazol to achieve the best results and minimize any risks associated with its use. If you have any questions or concerns about how to use Cilostazol, don’t hesitate to discuss them with your healthcare provider.

Other uses for this medicine

• Peripheral Arterial Disease (PAD): Cilostazol is sometimes used to improve symptoms in patients with PAD beyond intermittent claudication.
• Raynaud’s Phenomenon: There is some evidence suggesting Cilostazol may help improve symptoms in individuals with Raynaud’s phenomenon, a condition where blood flow to extremities is reduced in response to cold or stress.
• Platelet Aggregation Inhibition: Cilostazol inhibits platelet aggregation, so it has been studied for its potential role in preventing blood clots, particularly in patients at risk for thrombosis.

What special precautions should I follow?

Special precautions when using Cilostazol include:

• Cardiovascular Effects: Cilostazol may cause palpitations, tachycardia (rapid heartbeat), and other cardiovascular effects. It should be used cautiously in patients with a history of these conditions.
• Bleeding Risk: Due to its antiplatelet effects, Cilostazol can increase the risk of bleeding. Caution should be exercised in patients with a history of bleeding disorders or those taking other medications that affect blood clotting.
• Liver Function: Cilostazol is metabolized in the liver, so it should be used with caution in patients with liver impairment. Liver function tests may be necessary before starting treatment.
• Kidney Function: Adjustments to the dosage may be needed in patients with severe kidney impairment.
• Heart Failure: Cilostazol should not be used in patients with heart failure of any severity.
• Pregnancy and Breastfeeding: The safety of Cilostazol in pregnant or breastfeeding women has not been established. It should be used only if clearly needed and after careful consideration of the potential risks and benefits.
• Drug Interactions: Cilostazol can interact with other medications, including certain antibiotics, antifungals, and drugs used to treat HIV/AIDS. Always inform your healthcare provider about all medications you are taking.
• Monitoring: Regular monitoring of blood pressure, heart rate, and symptoms is recommended during treatment with Cilostazol.

It’s crucial to discuss any medical conditions you have and all medications you are taking with your healthcare provider before starting Cilostazol. This helps ensure safe and effective use of the medication tailored to your individual needs.

What special dietary instructions should I follow?

There are no specific dietary restrictions for Cilostazol. However, it’s generally advisable to maintain a healthy diet low in saturated fats and rich in fruits, vegetables, and whole grains. This type of diet can help support cardiovascular health, which complements the effects of Cilostazol in managing intermittent claudication.

What should I do if I forget a dose?

If you forget to take a dose of Cilostazol, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

What side effects can this medication cause?

Cilostazol, like any medication, can cause side effects. Not everyone will experience these side effects, and their severity can vary. Common side effects of Cilostazol include:

• Headache: This is one of the most commonly reported side effects.
• Diarrhea: Gastrointestinal disturbances such as diarrhea can occur.
• Palpitations: Some people may experience irregular or rapid heartbeat.
• Abnormal stools: Changes in stool consistency or color may occur.
• Flushing: A sensation of warmth or flushing of the skin can happen.
• Swelling of the legs or ankles: Peripheral edema may occur in some individuals.
• Dizziness: Feeling dizzy or lightheaded can occur, especially when standing up quickly.
• Abnormal heart rhythms: This includes tachycardia (rapid heartbeat) or arrhythmias in some cases.
• Headache: Occasional headaches have been reported.
• Other less common side effects: These may include nausea, vomiting, blurred vision, and low blood pressure.

Serious side effects are rare but can include severe allergic reactions, severe liver problems, and worsening heart conditions. If you experience any unusual symptoms or serious side effects while taking Cilostazol, it’s important to contact your healthcare provider immediately.

As with any medication, the benefits of Cilostazol in managing your condition should be weighed against the potential risks of side effects. Your healthcare provider can provide guidance on managing side effects and adjusting your treatment plan if necessary.

What should I know about storage and disposal of this medication?

Storage and Disposal of Cilostazol:

• Storage: Store Cilostazol tablets at room temperature between 20°C to 25°C (68°F to 77°F). Keep the medication in its original container, tightly closed, and out of reach of children and pets.
• Disposal: Dispose of any unused or expired Cilostazol tablets according to local regulations or guidelines. Do not flush them down the toilet or pour them into a drain unless specifically instructed to do so. Consult your pharmacist or local waste disposal company for proper disposal methods.

In case of emergency/overdose

• Emergency: If you suspect an overdose of Cilostazol or experience severe symptoms such as severe dizziness, fainting, or difficulty breathing, seek immediate medical attention or call your local emergency services.
• Overdose: Symptoms of overdose may include severe headache, dizziness, rapid heartbeat, and possibly low blood pressure. Treatment will focus on supportive measures to manage symptoms and may include monitoring of vital signs.

What other information should I know?

• Regular Follow-Up: Attend regular follow-up appointments with your healthcare provider to monitor your response to Cilostazol and any potential side effects.
• Missed Dose: If you forget to take a dose of Cilostazol, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
• Interactions: Inform your healthcare provider about all medications you are taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements. Some medications may interact with Cilostazol and affect its effectiveness or increase the risk of side effects.
• Medical Conditions: Inform your doctor about any medical conditions you have, especially heart conditions, liver or kidney problems, and bleeding disorders.
• Pregnancy and Breastfeeding: Discuss the risks and benefits of using Cilostazol if you are pregnant, planning to become pregnant, or breastfeeding.
• Driving and Activities: Cilostazol may cause dizziness or lightheadedness. Use caution when driving or operating machinery until you know how Cilostazol affects you.
• Alcohol: Limit alcohol consumption while taking Cilostazol, as alcohol can exacerbate certain side effects such as dizziness.

Following these guidelines will help ensure safe and effective use of Cilostazol as prescribed by your healthcare provider. If you have any questions or concerns about Cilostazol or your treatment plan, do not hesitate to discuss them with your doctor or pharmacist.