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Chlotride (Generic Chlorothiazide)

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Why is this medication prescribed?

To treat high blood pressure, chlorothiazide may be taken either on its own or in conjunction with other drugs. Chlorothiazide is used to treat edoema (fluid retention; excess fluid trapped in bodily tissues) brought on by a variety of illnesses, such as heart, kidney, and liver disease, as well as edoema brought on by the use of specific drugs, such as corticosteroids and oestrogen. Chlorothiazide belongs to the group of drugs known as diuretics, also known as “water pills”. It functions by causing the kidneys to excrete salt and water from the body through the urine.

High blood pressure is a common illness that, if left untreated, can harm the kidneys, brain, heart, blood vessels, and other organs. Heart disease, a heart attack, heart failure, a stroke, renal failure, eyesight loss, and other issues may result from damage to these organs. Making lifestyle modifications will help you control your blood pressure in addition to taking medication. These adjustments include quitting smoking, drinking alcohol in moderation, eating a diet low in fat and salt, keeping a healthy weight, and exercising for at least 30 minutes most days.

How should this medicine be used?

Chlorothiazide is available as a liquid and tablet for oral use. Typically, it is consumed once or twice a day. Use chlorothiazide at the same time(s) each day to manage hypertension. Chlorothiazide may be taken every day or just on particular days of the week when treating edoema. When taking this medication, eat a snack or a meal. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. When indicated, take chlorothiazide as prescribed. Never take it in larger or less amounts or more frequently than directed by your doctor.

Chlorothizide reduces edoema and high blood pressure but does not treat either condition. Even if you feel good, keep taking chlorothiazide. Avoid stopping chlorothiazide use without first consulting your doctor.

Other uses for this medicine

Chlorothiazide may also be used to avoid kidney stones in patients with excessive blood calcium levels, treat people with diabetes insipidus, treat some electrolyte imbalances, and treat patients with diabetes insipidus. Discuss the potential dangers of using this medicine for your illness with your doctor.

Ask your doctor or pharmacist for more details if you’re interested in using this drug for any other conditions.

What special precautions should I follow?

Before taking chlorothiazide,

  • If you have any allergies, including to penicillin, sulfonamide antibiotics, chlorothiazide, other drugs, or any of the substances in chlorothiazide tablets or suspension, inform your doctor and pharmacist right away. For a list of the ingredients, consult the patient information or speak with your pharmacist.
  • Inform your doctor and pharmacist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products that you are now taking or intend to use. Incorporate any of the following: Benzodiazepines like phenobarbital and secobarbital (Seconal); corticosteroids like betamethasone (Celestone), budesonide (Entocort), cortisone (Cortone), dexamethasone (Decadron, Dexpak, Dexasone, and others); fludrocortisone (Floriner), and hydrocortisone; and barbiturates such phenobarbit (Cortef, Hydrocortone), methylprednisolone (Medrol), prednisolone (Prelone, others), prednisone (Deltasone, Meticorten, Sterapred, others), and triamcinolone (Aristocort, Azmacort); corticotropin (ACTH H.P., Acthar Gel); digoxin (Lanoxin); insulin and oral diabetes medications; lithium (Lithobid); drugs for high blood pressure or pain; and (Aleve, Naprosyn, others). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Take cholestyramine or colestipol an hour before or four hours after taking chlorothiazide if you also take those medications.
  • In case you have kidney illness, let your doctor know. You could be advised by your doctor not to take chlorothiazide.
  • Inform your doctor if you have or have previously had any of the following conditions: gout, liver, parathyroid, high cholesterol, systemic lupus erythematosus (SLE), asthma, diabetes, or high cholesterol.
  • Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. Call your doctor right away if you get pregnant while taking chlorothiazide.
  • Have a plan to limit your time spent in the sun and to use sunscreen, sunglasses, and protective clothes. Your skin may become sun-sensitive when using chlorothiazide.
  • You should be aware that if you stand up too rapidly from a laying position while taking chlorothiazide, you could have dizziness, lightheadedness, and fainting. When you initially start taking chlorothiazide, this happens more frequently. Get out of bed gradually, resting your feet on the floor for a few minutes before standing up, to avoid this issue. These negative effects may be exacerbated by alcohol.

What special dietary instructions should I follow?

Follow these directions carefully if your doctor advises you to eat or drink more potassium-rich foods (such as bananas, prunes, raisins, and orange juice) or to follow a low-salt or low-sodium diet.

What should I do if I forget a dose?

As soon as you recall, take the missed dose. Skip the missed dose and carry on with your regular dosing plan, though, if it is almost time for your next dose. Never take two doses at once to make up for missing ones.

What side effects can this medication cause?

If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Excessive urination
  • Muscles cramping
  • Fuzzy vision
  • Constipation
  • Diarrhoea
  • Vomiting
  • Reduced appetite
  • Headache
  • Hair fall

Certain adverse effects can be very harmful. Call your doctor right away if you develop any of these symptoms, or go to the hospital for emergency care:

  • Symptoms of dehydration and electrolyte imbalance include a dry mouth, thirst, nausea, vomiting, weakness, fatigue, drowsiness, restlessness, confusion, muscle weakness, soreness, or cramps, and a rapid heartbeat.
  • Fever
  • Flaking or blistering skin
  • Breathing or swallowing challenges
  • Hives
  • Rash
  • Itching
  • Eyes or skin that have a yellow tint

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Keep it away from excessive heat and moisture at room temperature (not in the bathroom). The oral suspension shouldn’t freeze.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at for additional information.

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your appointments with your physician and the lab. Blood tests should be performed occasionally, and your blood pressure should be checked often.

Inform the lab staff and your doctor that you are taking chlorothiazide prior to any laboratory test.

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Chlotride®
  • Diuril®
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