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Chlorodeoxyadenosine (Generic Cladribine Injection)

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Cladribine injection must be administered in a hospital or other healthcare institution under the guidance of a physician with training in administering chemotherapy drugs for cancer.

Your blood may contain significantly fewer blood cells of all sorts as a result of cladribine. This could result in specific symptoms and raise your risk of getting a serious infection or bleeding. Call your doctor right away if you have any of the following symptoms: The following symptoms of infection should be looked for: fever, sore throat, chills, or other infection-related symptoms; unusual bleeding or bruising; black and tarry stools; red blood in stools; bloody vomit; or vomited material that resembles coffee grounds.

Cladribine may seriously harm your nerves. More than a month after receiving a cladribine injection, nerve damage could develop. Call your doctor right away if you have any of the following symptoms: Hands or feet experiencing pain, burning, numbness, or tingling; arms or legs becoming weak; or losing the ability to move your arms or legs.

Serious kidney issues could result from cladribine use. Inform your doctor if you currently have kidney disease or have ever had it. Inform your physician and pharmacist if you are taking any aminoglycoside antibiotics, including amikacin (Amikin), gentamicin (Garamycin), or tobramycin (Tobi, Nebcin), as well as amphotericin B (Amphotec, Fungizone); medications that block the action of the angiotensin-converting enzyme (ACE), such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril); or non-steroidal anti-inflammatory drugs (NSAIDs), such as sulindac, naproxen (Aleve, Naprosyn), and diclofenac (Cataflam, Voltaren) (Clinoril). Call your doctor right away if you have any of the following symptoms: reduced urination, face, arm, hand, foot, ankle, or lower leg edoema, unusual fatigue, or weakness.

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to cladribine, your doctor will prescribe a number of tests prior to, during, and after therapy.

Why is this medication prescribed?

Hairy cell leukaemia is treated with cladribine (cancer of a certain type of white blood cell). Cladribine belongs to a group of drugs called purine analogues. By delaying or halting the growth of cancer cells, it combats cancer.

How should this medicine be used?

In a medical setting, a doctor or nurse will provide cladribine injection intravenously (into a vein) using a solution (liquid). It is typically injected continuously into the vein over the course of 7 days.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving cladribine,

  • If you have an allergy to cladribine, any other drugs, or any of the ingredients in cladribine injection, let your doctor and pharmacist know right once. Get a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use. Mention any immunosuppressants, such as azathioprine (Imuran), cyclosporine (Neoral, Sandimmune), methotrexate (Rheumatrex), sirolimus (Rapamune), and tacrolimus, as well as the drugs specified in the IMPORTANT WARNING section (Prograf). You’ll need to be closely watched by your doctor for any negative effects. Tell your doctor about all of your current medications, even those not on this list, as many additional drugs may interact with cladribine.
  • If you have liver illness now or previously, let your doctor know.
  • Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Pregnancy should not occur while you are using cladribine. Call your doctor if you get pregnant while taking cladribine. The foetus could suffer from cladribine.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What side effects can this medication cause?

Side effects from cladribine are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Constipation
  • Reduced appetite
  • Body rash
  • Headache
  • Excessive perspiration
  • Pain, swelling, redness, or blisters where the injection site for the medicine was

Some adverse effects may be severe. Call your doctor right away if you have any of the following symptoms or any of the ones detailed in the IMPORTANT CAUTION section:

  • Light skin
  • Extreme fatigue
  • Breathing difficulty
  • Dizziness
  • Rapid heart rate

There could be more negative consequences from cladribine. If you have any strange side effects while taking this medicine, contact your doctor right away.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  • Less urinations
  • Edoema of the lower legs, lower arms, hands, feet, ankles, or face
  • Unexpected fatigue or weakened state
  • Uncommon bruising or bleeding
  • Bloody or dark-colored stools
  • Vomit that has blood in it or looks like coffee grounds
  • Fever, chills, a sore throat, or other symptoms of infection
  • Hands or foot pain, burning, numbness, or tingling
  • Legs or arms are feeble.
  • Lack of arm or leg movement.

What other information should I know?

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Leustatin®
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