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Your bone marrow may produce fewer blood cells as a result of chlorambucil. Before, during, and after your treatment, your doctor will request laboratory tests to see whether this medication has had an impact on your blood cells. Be on time for all appointments with the lab.

Chlorambucil may make you more likely to get other cancers. Your doctor should be informed of this danger.

Chlorambucil may disrupt a woman’s regular menstrual cycle and may prevent sperm from developing in a man. Although chlorambucil has the potential to induce permanent infertility (difficulty getting pregnant), this does not mean that you cannot become pregnant or that you cannot help another person become pregnant. Pregnant women should inform their doctors before starting this medication. When undergoing chemotherapy or for a while after treatments, you shouldn’t intend to get pregnant. (Ask your doctor for more information.) To prevent conception, use a proven birth control method. Call your doctor right away if you become pregnant while taking chlorambucil. The foetus could suffer from chlorambucil.

Why is this medication prescribed?

Chronic lymphocytic leukaemia of a specific type is treated with chlorambucil (CLL; a type of cancer of the white blood cells). Moreover, non-Hodgkin lymphoma (NHL) and Hodgkin’s disease are both managed with chlorambucil (types of cancer that begin in certain white blood cells that normally fight infection). Alkylating agents are a class of drugs that includes chlorambucil. It functions by reducing or halting the development of cancer cells within your body.

How should this medicine be used?

Chlorambucil is available as an oral tablet. It is often taken once a day for three to six weeks, however it can also be given only occasionally, as a single dose once every two weeks or once a month. The sort of drugs you are taking, how well your body reacts to them, and the type of cancer you have will all affect how long your treatment will last. Take chlorambucil every day at roughly the same time. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Just as prescribed, take chlorambucil. Never take it in larger or less amounts or more frequently than directed by your doctor.

Depending on how you respond to the medication and any adverse effects you experience, your doctor may change the dosage of chlorambucil you are taking. Discuss your feelings regarding your treatment with your doctor. Without consulting your doctor, do not discontinue taking chlorambucil.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking chlorambucil,

  • Inform your doctor and pharmacist if you have any allergies to chlorambucil, other alkylating agents like cyclophosphamide (Cytoxan), ifosfamide (Ifex), lomustine (CeeNU), melphalan (Alkeran), procarbazine (Mutalane), or temozolomide (Temodar), any other medications, or any of the ingredients in chlorambucil. Get an ingredient list from your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are now taking or intend to use.
  • If you have previously taken chlorambucil but your cancer did not improve, let your doctor know. Most likely, your doctor will advise against using chlorambucil.
  • If you have had chemotherapy or radiation therapy within the last four weeks, let your doctor know.
  • If you’ve ever experienced seizures or a head injury, let your doctor know.
  • Inform your doctor if you are nursing a baby.
  • Avoid getting any shots without first consulting your doctor.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

There may be negative effects from chlorambucil. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Nausea
  • Vomiting
  • Mouth- and throat-related sores
  • Tiredness
  • Missing menstrual cycles (in girls and women)

Some adverse effects may be severe. Call your doctor right away if you notice any of these signs:

  • Body rash
  • Significant bruising or bleeding
  • Tarry, black stools
  • Red faeces
  • Cough
  • Unwell throat
  • Congestion
  • Fever
  • Having trouble breathing
  • Seizures
  • Eyes or skin that have a yellow tint
  • Stomach ache in the top right corner
  • Urine with a dark colour
  • Excessive urination
  • Odd mounds or lumps

Further negative effects of chlorambucil are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. It should be kept in the fridge.

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

Keep all of your doctor’s appointments.

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Leukeran®
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