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Carfilzomib Injection

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Why is this medication prescribed?

Patients with multiple myeloma (a kind of bone marrow cancer) who have received prior treatment with other medications may receive carfilzomib injection alone or in addition to other medications. A group of drugs known as proteasome inhibitors includes carfilzomib. It operates by delaying or halting the growth of cancer cells within your body.

How should this medicine be used?

When combined with fluids, the powder form of carfilzomib is administered intravenously (into a vein). In a medical office or clinic, carfilzomib is often administered by a doctor or nurse over the course of 10 to 30 minutes. It can be administered twice a week for three weeks, followed by a 12-day break, or once a week for three weeks, then a 13-day break. How effectively your body responds to the drug will determine how long the treatment will last.

After receiving a dose of the drug, you may have severe or life-threatening side effects for up to 24 hours. Before receiving each dose of carfilzomib, you will be given specific drugs to assist prevent an adverse response. After receiving therapy, report any of the following symptoms to your doctor right away: fever, chills, joint or muscle pain, flushing or facial swelling, tightening or swelling of the throat, vomiting, weakness, shortness of breath, disorientation or fainting, or chest tightness or pain.

In order to receive the best care, be sure to communicate your feelings to your doctor. If you develop negative effects from taking carfilzomib, your doctor may shorten the duration of your therapy or reduce your dose.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving carfilzomib injection,

  • If you have an allergy to carfilzomib, any other medications, or any of the ingredients in carfilzomib injection, let your doctor and pharmacist know right away. Get a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products that you are now taking or intend to use. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • If you have or have ever had heart failure, a heart attack, an irregular heartbeat, or any other heart issues, high blood pressure, a herpes infection (cold sores, shingles, or genital sores), seizures, or any other neurological illness, be sure to let your doctor know. Furthermore let your doctor know if you are receiving dialysis or have liver or kidney problems.
  • Inform your doctor if you intend to father a child, are already pregnant, or think you could become pregnant. Pregnancy should not occur while you are taking carfilzomib, either for you or your partner. You must perform a pregnancy test before commencing therapy if you are a female, and you should use birth control to avoid getting pregnant while taking carfilzomib and for six months after your last dose. If you are a man, you should use birth control to avoid getting pregnant while receiving carfilzomib medication and for three months following your last dosage. Call your doctor if you or your partner become pregnant while taking this medicine. The foetus could suffer from carfilzomib.
  • If you are breastfeeding, let your doctor know. Don’t breastfeed for two weeks after your final dose of carfilzomib injection and throughout the whole duration of your treatment.
  • You should be aware that carfilzomib might cause fainting, dizziness, and drowsiness. Until you are certain of how this drug affects you, avoid operating machinery or driving.

What special dietary instructions should I follow?

Be sure to stay hydrated before and throughout your carfilzomib therapy, especially if you vomit or have diarrhoea.

What side effects can this medication cause?

The injection of carfilzomib may have adverse effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Tiredness
  • Headache
  • Weakness
  • Diarrhea
  • Constipation
  • Spasm of muscles
  • Either the arms or legs hurt

Some adverse effects may be severe. Call your physician if you encounter any of these signs or any of the ones detailed in the HOW and SPECIAL PRECAUTIONS sections:

  • Cough
  • Dehydration symptoms include dry mouth, dark urine, decreased sweating, dry skin, and other symptoms.
  • Swelling in the legs’ feet
  • Leg discomfort, soreness, or erythema
  • Respiratory issues or lack of breath
  • Chest ache
  • Hands or foot pain, burning, numbness, or tingling
  • Nausea
  • Unexpected fatigue or weakened state
  • Uncommon bruising or bleeding
  • Not enough energy
  • Reduced appetite
  • Stomach ache in the top right corner
  • Eyes or skin that have a yellow tint
  • Flu-like signs
  • Dark, tarry, or bloody stools
  • Blood in the urine and a rash of tiny reddish-purple dots, commonly on the lower legs.
  • Less urinations
  • Seizures
  • Eyesight alterations or blindness
  • Confusion, memory loss, vertigo or loss of balance, trouble speaking or walking, vision problems, diminished strength or weakness on one side of the body, and confusion with memory

Further negative effects of carfilzomib injection are possible. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  • Chills
  • Dizziness
  • Less urinations

What other information should I know?

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to carfilzomib, your doctor will order specific tests and perform routine blood pressure checks.

Any queries you may have regarding carfilzomib injection, ask your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Kyprolis®
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