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Captopril and Hydrochlorothiazide

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If you are pregnant, avoid using hydrochlorothiazide and captopril. Call your doctor right away if you get pregnant while taking hydrochlorothiazide and captopril. The foetus could be harmed by captopril and hydrochlorothiazide.

Why is this medication prescribed?

Captopril and hydrochlorothiazide are combined to treat high blood pressure. Angiotensin-converting enzyme (ACE) inhibitors, which include captopril, are a group of drugs. By lowering specific molecules that stiffen blood arteries, it increases blood flow. Diuretics, also known as “water pills,” include hydrochlorothiazide. It works by encouraging the kidneys to excrete extra salt and water from the body into the urine.

Captopril and hydrochlorothiazide are combined to treat high blood pressure. Angiotensin-converting enzyme (ACE) inhibitors, which include captopril, are a group of drugs. By lowering specific molecules that stiffen blood arteries, it increases blood flow. Diuretics, also known as “water pills,” include hydrochlorothiazide. It works by encouraging the kidneys to excrete extra salt and water from the body into the urine.

How should this medicine be used?

The oral tablet containing captopril and hydrochlorothiazide is available. It is often taken once or twice daily, an hour before meals, on an empty stomach. Use the same time(s) every day to help you remember to take hydrochlorothiazide and captopril. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Use hydrochlorothiazide and captopril exactly as prescribed. Never take it in larger or less amounts or more frequently than directed by your doctor.

Your doctor may prescribe you a modest dose of hydrochlorothiazide and captopril to start, and then gradually raise it not more than once every 6 to 8 weeks.

Although they can help manage high blood pressure, captopril and hydrochlorothiazide do not cure it. Even if you feel better, keep taking captopril and hydrochlorothiazide. Without consulting your doctor, do not stop taking hydrochlorothiazide with captopril.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking captopril and hydrochlorothiazide,

  • Angiotensin-converting enzyme (ACE) inhibitors such benazepril (Lotensin, in Lotrel), enalapril (Vasotec, in Vaseretic), and fosinopril should be avoided if you have allergies to captopril (Capoten), hydrochlorothiazide (HCTZ; Microzide, Oretic), and hydrochlorothiazide (Monopril), lisinopril (in Prinzide, in Zestoretic), moexipril (in Uniretic), perindopril (in Aceon), quinapril (in Accuretic, in Quinaretic), ramipril (in Altace), and trandolapril (in Tarka); sulfa drugs; other medications; or any of the components in captopril and hydrochlorothiazide pills. Get an ingredient list from your pharmacist.
  • If you are currently using valsartan and sacubitril (Entresto), or if you have just stopped taking it, let your doctor or pharmacist know. If you also take valsartan and sacubitril, your doctor will likely advise against using captopril and hydrochlorothiazide. Moreover, let your physician know if you have diabetes and are on aliskiren (Tekturna, in Amturnide, in Tekamlo, in Tekturna HCT). If you have diabetes and are also on aliskiren, your doctor generally won’t let you take captopril and hydrochlorothiazide.
  • Inform your physician and pharmacist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are taking. Incorporate any of the following: amphotericin B (Amphotec, Ambisome); warfarin (Coumadin, Jantoven) and other anticoagulants (also known as “blood thinners”), aspirin and other NSAIDs like indomethacin (Indocin, Tivorbex), calcium supplements, cancer chemotherapy drugs, cholestyramine (Prevalite), as well as calcium supplements; Digoxin (Lanoxin), lithium (Lithobid), probenecid (Probalan) for gout, methenamine (Hiprex, Urex), colestipol (Colestid), insulin or oral diabetes medications; lithium; colestipol (Colestid); digoxin (Lanoxin); insulin or oral diabetes medications; probenecid (Probalan) for gout; digoxin (Lanoxin); digoxin (Lanoxin); nitrates such as isosorbide dinitrate (Isordil, in Bidil), isosorbide mononitrate (Monoket), and nitroglycerin (Nitro-Dur, Nitrostat, other brands); monoamine oxidase (MAO) inhibitors such as phenelzine (Nardil) and tranylcypromine (Parnate); dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos) are examples of oral steroids. Other diuretics, various drugs for high blood pressure, pain relievers, phenobarbital (Luminal), and potassium supplements are more examples. Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your doctor if you have or have had had lupus, scleroderma, heart failure, diabetes, allergy, asthma, liver disease, or renal illness. Scleroderma is a disorder where excess tissue forms on the skin and several organs.
  • Inform your doctor if you are nursing a child.
  • Inform your doctor or dentist that you are taking captopril and hydrochlorothiazide if you are having surgery, including dental surgery.
  • While taking hydrochlorothiazide and captopril, consult your doctor about whether it is safe to consume alcohol. The adverse effects of hydrochlorothiazide and captopril may be exacerbated by alcohol.
  • You should be aware that low blood pressure can lead to dizziness and fainting. This might happen when you have diarrhoea, vomit, are dehydrated, or are sweating excessively.

What special dietary instructions should I follow?

Before using potassium-containing salt replacements, consult your doctor. If your doctor advises a low-sodium (low-salt) diet, carefully follow their instructions.

What should I do if I forget a dose?

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

Side effects are possible with captopril plus hydrochlorothiazide. If any of these symptoms are severe or do not go away, consult your doctor:

  • Cough
  • Feeling unsteady or lightheaded
  • Changing tastes
  • Rash
  • Itching

Some adverse effects may be severe. Call your doctor right away if you notice any of these signs:

  • Edoema of the hands, feet, ankles, lower legs, cheeks, neck, tongue, lips, and eyes
  • Hoarseness
  • Breathing or swallowing challenges
  • Infection symptoms such a fever, sore throat, chills, and others
  • Eyes or skin that have a yellow tint
  • Mouth ache
  • Thirst
  • Weakness
  • Not enough energy
  • Restlessness
  • Cramping or aching muscles
  • Sporadic urination
  • Uneasy stomach
  • Vomiting
  • Fainting
  • Chest pain
  • Irregular, hammering, or quick heartbeat

Hydrochlorothiazide with captopril may also have additional adverse effects. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Keep it away from excessive heat and moisture at room temperature (not in the bathroom).

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at for additional information.

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  • Drowsiness
  • Coma
  • Having trouble breathing
  • Abdominal pain

What other information should I know?

Keep all of your appointments with your physician and the lab. Regular blood pressure checks will help you determine how well captopril and hydrochlorothiazide are working for you. To determine how your body is responding to captopril and hydrochlorothiazide, your doctor may request specific lab tests.

Inform the lab staff and your doctor that you are taking hydrochlorothiazide and captopril prior to any laboratory test.

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names of combination products

  • Capozide®
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