Injections of caplacizumab-yhdp are used in conjunction with plasma exchange therapy and immunosuppressive drugs to treat acquired thrombotic thrombocytopenic purpura (aTTP; a condition in which the body attacks itself and results in clots, low levels of platelets and red blood cells, and may cause other serious complications). Antithrombotic agents are a class of drugs that includes caplacizumab-yhdp. It functions by preventing a certain chemical from acting in the body and causing the symptoms of aTTP.

Caplacizumab-yhdp is a powder that must be dissolved in a liquid before being injected intravenously or subcutaneously. It is typically administered twice on the first day of treatment: once as a subcutaneous injection after plasma exchange and once as an intravenous infusion at least 15 minutes before plasma exchange. It is typically administered as a once-day subcutaneous injection after plasma exchange for as long as you get plasma exchange therapy, and then once daily for an additional 30 to 58 days after stopping plasma exchange therapy, starting on the second day of treatment. Use caplacizumab-yhdp every day at roughly the same time. If there is anything you do not understand about the instructions on your prescription label, contact your doctor or pharmacist to clarify it. Follow the caplacizumab-yhdp directions exactly. Use only as directed by your doctor, either in the recommended amount or frequency.

Your doctor could approve of having an assistant administer the injections for you. In order to prepare and administer caplacizumab-yhdp, ask your doctor or pharmacist to demonstrate the process to you or the person administering the injections. Read the enclosed written instructions before administering caplacizumab-yhdp injection for the first time. For a copy of the manufacturer’s directions for use information for the patient, ask your pharmacist or doctor.

Caplacizumab-Yhdp injection should be administered subcutaneously in the abdomen (stomach) region; however, you should avoid injecting into your navel or the area 2 inches (5.1 cm) around it. Don’t use the same injection site back-to-back days.

Put used needles, syringes, and vials in a container that won’t puncture. How to get rid of the puncture-resistant container should be discussed with your doctor or pharmacist.

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

Before receiving caplacizumab-yhdp,

• If you have any allergies, including to any inactive substances in caplacizumab-yhdp injection, tell your doctor right away. Get a list of the components from your pharmacist.
• Inform your doctor and pharmacist about all prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products that you are now taking or intend to use. If you use any of the following medications, make sure to include them: apixaban (Eliquis), clopidogrel (Plavix), dabigatran (Pradaxa), dipyrimadole (Persantine, in Aggrenox), edoxaban (Savaysa), enoxaparin (Lovenox), fondaparinux (Arixtra), heparin, prasugrel (Effient (Coumadin, Jantoven). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
• Inform your doctor if you have or have had had liver illness, any bleeding issues, haemophilia (a genetic abnormality in which the body cannot stop bleeding correctly), or any other bleeding issues.
• Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Call your doctor if you conceive while taking caplacizumab-yhdp.
• Inform your doctor or dentist that you are using caplacizumab-yhdp if you are having surgery, including dental surgery. You could be instructed to stop using caplacizumab-yhdp seven days before to surgery by your doctor or dentist.

Keep eating normally unless your doctor instructs you otherwise.

The missed dose should be taken as soon as you remember. If, however, more than 12 hours have passed since the missed dose and you are no longer getting plasma exchange therapy, skip the missing dose and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

Side effects from caplacizumab-yhdp are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

• Headache
• Extreme fatigue
• Back ache
• Muscular ache
• Skin sensations of tingling, prickling, or numbness
• Itching close to where the injection site was
• Breathing difficulty
• Fever

Certain adverse effects can be very harmful. Call your doctor right away if you encounter any of these symptoms, or seek emergency care:

• Hives
• Bleeding from the mouth, nose, rectum, vagina, or the injection site, among other places, that won’t stop
• Throwing up blood
• Black or crimson tarry stools
• Urinary blood
• Abrupt vomiting, nausea, and a strong headache
• Abrupt, severe stomach pain, nausea, and vomiting
• Frequent, uncomfortable, or necessary urinating

Injections of caplacizumab-yhdp may result in additional adverse effects. If you have any strange side effects while taking this medicine, call your doctor right away.

You or your doctor can report a significant side effect to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme by phone or online at http://www.fda.gov/Safety/MedWatch (1-800-332-1088).

Keep this medication tightly closed in the original container and out of the reach of children. Keep it out of the light and in the refrigerator. Avoid freezing. The injection of caplacizumab-yhdp may be stored at room temperature for up to two months, however it should be protected from light by remaining in its original carton. Once caplacizumab-yhdp has been kept at room temperature, it shouldn’t be put back in the fridge.

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning. http://www.upandaway.org

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at http://goo.gl/c4Rm4p for additional information.

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose symptoms could include:

• Bleeding

Keep all of your appointments with your physician and the lab. In order to determine if caplacizumab-yhdp medication should be continued, your doctor will request a number of lab tests.

Do not share your medication with anybody else. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.