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Camzyos (Generic Mavacamten)

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Heart failure may be brought on by mavacamten. If your doctor has ever told you that you have heart failure or that you have poor ejection fraction, please let them know (how well your left ventricle pumps blood). Any drugs you are taking, including over-the-counter remedies like St. John’s Wort, omeprazole, esomeprazole, or cimetidine, should be disclosed to your doctor and pharmacist before beginning therapy with mavacamten. Call your doctor right away or get medical attention if you have any of the following symptoms: Breathlessness, chest pain, exhaustion, limb swelling, a racing feeling in your heart, and rapid weight gain.

Keep all of your doctor’s appointments. Before beginning and throughout your mavacamten medication, your doctor will request an echocardiography.

If you need a prescription refill for mavacamten, your doctor or pharmacist will provide you the manufacturer’s patient information leaflet (Medication Guide). If you have any questions, carefully read the material and contact your doctor or pharmacist. To obtain the Medication Guide, you can also go to or the Food and Drug Administration (FDA) website (

Discuss the potential risks of taking mavacamten with your doctor.

A programme called CAMZYOS Risk Evaluation and Mitigation Strategy (CAMZYOS REMS) has been established due to the danger of heart failure to ensure that the proper monitoring for heart failure is carried out while receiving therapy with mavacamten. Your doctor will sign you up for CAMZYOS REMS, and you’ll have to buy mavacamten from a particular pharmacy.

Why is this medication prescribed?

Adults with symptomatic obstructive hypertrophic cardiomyopathy are treated with mavacamten. Mavacamten belongs to the group of drugs known as cardiac myosin inhibitors. It functions by lessening the contact between actin and myosin, the proteins that cause the heart to contract, resulting in a softer squeezing.

How should this medicine be used?

Mavacamten is available as an oral capsule. Once a day, it is typically taken with or without food. Mavacamten should be taken every day at around the same time. Ask your doctor or pharmacist to explain any instructions on your prescription label that you do not understand, and carefully follow their instructions. Just as prescribed, take mavacamten. Never take it in quantities or frequencies other than those recommended by your doctor.

Do not split, chew, or crush the tablets or capsules; instead, swallow them whole.

Mavacamten will likely be prescribed to you at a low dosage by your doctor, who will then progressively adjust it based on how you react to it and how you feel.

Symptomatic obstructive hypertrophic cardiomyopathy is not cured by mavacamten, however it can be controlled. Even if you feel good, keep taking mavacamten. Without consulting your doctor, do not discontinue taking mavacamten.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking mavacamten,

  • If you have an allergy to mavacamten, any other drugs, or any of the substances in mavacamten capsules, notify your doctor right away. For a list of the ingredients, consult the Medication Guide or speak with your pharmacist.
  • Mavacamten should not be taken with some medications, while other medications may need a dose adjustment or special supervision when using mavacamten. Before beginning mavacamten, make sure your doctor and pharmacist are aware of any medications you are taking or intend to take. Always with your doctor or pharmacist before starting, stopping, or changing any medications while using mavacamten. In addition to prescription and over-the-counter medications, make sure to let your doctor or pharmacist know about all vitamins, dietary supplements, and herbal products.
  • You should be aware that mavacamten can lessen how well hormonal contraceptives work (birth control pills, patches, rings, and injections). While taking mavacamten, for four months after quitting mavacamten, and while using an intrauterine device or condom, you must use another method of contraception to avoid getting pregnant. When taking this drug, discuss alternate birth control options with your doctor.
  • If you have or have ever had an infection or an arrhythmia, let your doctor know (problem with rate or rhythm of your heart).
  • Mavacamten can be bad for your unborn child. Inform your doctor if you are expecting, intend to get pregnant, or are nursing a baby. Mavacamten can cause pregnancy, so call your doctor right once if it does. Before you begin taking Mavacamten, your doctor will perform a pregnancy test on any female patients. Throughout your mavacamten treatment and for four months after it ends, you should use a reliable method of birth control, such as condoms or an intrauterine device.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. Never double up on a dose to make up for a forgotten one.

What side effects can this medication cause?

Mavacamten could have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Dizziness
  • Fainting

Certain adverse effects can be very harmful. Call your doctor right away or seek emergency medical attention if you develop any of the symptoms mentioned in the IMPORTANT WARNING section.

Further negative effects of mavacamten are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Keep it away from excessive heat and moisture at room temperature (not in the bathroom).

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

What other information should I know?

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Camzyos®
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