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Calcium, Magnesium, Potassium, and Sodium Oxybate

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WARNING

GHB is also known as calcium, magnesium, potassium, and sodium oxybate, a drug that is frequently marketed and abused illegally, especially by young adults in public places like nightclubs. Inform your doctor if you currently use or have previously used excessive amounts of street drugs, alcohol, or prescription medications. When used by individuals other than the person for whom they were given, calcium, magnesium, potassium, and sodium oxybate may be dangerous. It is illegal to sell or share calcium, magnesium, potassium, and sodium oxybate, thus refrain from doing so. To prevent accidental or intentional theft, keep calcium, magnesium, potassium, and sodium oxybate in a secure location, like a locked cabinet or box. You’ll be able to detect any missing liquid if you keep track of how much is still in your bottle.

Serious side effects with calcium, magnesium, potassium, and sodium oxybate include life-threatening or extremely significant breathing issues. While receiving treatment with calcium, magnesium, potassium, and sodium oxybate, you run a higher risk of developing serious or life-threatening respiratory issues, drowsiness, or fainting if you take certain medications. Describe to your doctor any use of sleeping drugs. If you are taking this drug, your doctor would probably advise you to avoid taking calcium, magnesium, potassium, and sodium oxybate. Moreover, let your doctor know if you use any benzodiazepines, including estazolam, flurazepam, lorazepam (Ativan), oxazepam, clonazepam, chlordiazepoxide (Librium), and alprazolam (Xanax), temazepam (Restoril) and triazolam (Halcion), drugs for nausea, seizures, or mental disease, muscle relaxants, or narcotic painkillers are some examples of these drugs. In addition to closely monitoring you, your doctor might need to adjust the doses of your medications. If you’re taking calcium, magnesium, potassium, and sodium oxybate, avoid drinking alcohol during that time.

Retail pharmacies do not carry calcium, magnesium, potassium, or sodium oxybate. Only a restricted distribution scheme known as the Xywav and Xyrem REMS Program provides access to calcium, magnesium, potassium, and sodium oxybate. It is a unique programme designed to disperse medication and deliver information on medication. You will receive your medication by mail from a central pharmacy after reading the information and speaking with a pharmacist. If you have any concerns about how you will take your prescription, talk to your doctor.

The patient information sheet (Medication Guide) from the manufacturer will be sent to you by your doctor or pharmacist when you start taking calcium, magnesium, potassium, and sodium oxybate as well as every time you get your prescription filled. If you have any questions, carefully read the material and contact your doctor or pharmacist. The Medication Guide is also available on the FDA website.

Keep all of your doctor’s appointments.

The dangers of taking calcium, magnesium, potassium, and sodium oxybate should be discussed with your doctor.

Why is this medication prescribed?

A combination of calcium, magnesium, potassium, and sodium oxybate is used to treat excessive daytime drowsiness in adults and children with narcolepsy as well as cataplexy attacks, which are brief episodes of muscle weakness (a sleep disorder that may cause extreme sleepiness, sudden uncontrollable urge to sleep during daily activities, and cataplexy). The treatment of individuals with idiopathic hypersomnia also includes the use of calcium, magnesium, potassium, and sodium oxybate (IH; a sleep disorder that may cause excessive daytime sleepiness and uncontrollable urge to sleep during daily activities despite adequate or prolonged nighttime sleep). The drugs known as central nervous system depressants include calcium, magnesium, potassium, and sodium oxybate. By lowering brain activity, calcium, magnesium, potassium, and sodium oxybate is effective in treating narcolepsy, cataplexy, and idiopathic hypersomnia.

How should this medicine be used?

Oxybate of calcium, magnesium, potassium, and sodium is available as a solution (liquid) that can be diluted with water and used orally. When calcium, magnesium, potassium, and sodium oxybate is used to treat cataplexy and excessive daytime sleepiness in patients with cataplexy, it is typically taken twice each night because the effects of one dose do not last for the entire night. This is because calcium, magnesium, potassium, and sodium oxybate wears off after a short period of time. It is typical to take calcium, magnesium, potassium, and sodium oxybate once or twice every night when treating idiopathic hypersomnia. The first dose is taken before going to bed, and the second dose is taken between two and four hours later. The initial dose of calcium, magnesium, potassium, and sodium oxybate should be given at least two hours after eating because they must be taken on an empty stomach. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following.

Take your calcium, magnesium, potassium, and sodium oxybate nighttime doses only after you or your child is in bed and prepared to sleep for the night. Within 5 to 15 minutes of ingesting it, calcium, magnesium, potassium, and sodium oxybate starts to function very quickly. Place your second dose of calcium, magnesium, potassium, and sodium oxybate in a secure location close to your bed (or in a secure location to give to your kid) before going to sleep if your doctor has instructed you to do so. To ensure that you will awaken in time to take the second dose, set an alarm. Take your second dose, turn off the alarm, and go back to bed if you or your kid wake up before the alarm goes off and it has been at least 2 1/2 hours since your first dose.

A low amount of calcium, magnesium, potassium, and sodium oxybate will likely be prescribed by your doctor, who will then likely gradually increase it up to once a week.

It’s possible for calcium, magnesium, potassium, and sodium oxybate to become habits. Never take it in larger or more frequent doses than recommended by your doctor. Seizures, slowed or stopped breathing, loss of consciousness, and coma are just a few of the life-threatening symptoms that can occur if you take too much calcium, magnesium, potassium, and sodium oxybate. Also possible are cravings for calcium, magnesium, potassium, and sodium oxybate, the need to take ever-increasing amounts, and the desire to keep taking the medication even in the face of severe side effects. You may experience withdrawal symptoms like trouble falling asleep or staying asleep, restlessness, anxiety, strange thinking, losing touch with reality, sleepiness, upset stomach, shaking of a part of your body that you cannot control, sweating, muscle cramps, and a rapid heartbeat if you suddenly stop taking calcium, magnesium, potassium, and sodium oxybate.

The combination of calcium, magnesium, potassium, and sodium oxybate may help you manage your symptoms but won’t make your problem go away. Even if you feel better, keep taking sodium oxybate, potassium, magnesium, and calcium supplements. Stop using calcium, magnesium, potassium, and sodium oxybate only after consulting your doctor. Your doctor will likely want to progressively reduce your dose. If you abruptly stop taking calcium, magnesium, potassium, and sodium oxybate, you can experience more cataplexy spells, anxiety, and trouble sleeping or staying asleep.

The methods below should be followed to prepare dosages of calcium, magnesium, potassium, and sodium oxybate:

  • Take the drug bottle and the measuring equipment out of the carton your medication was packaged in.
  • Take the measuring instrument out of its packaging.
  • Pushing down on the cap while simultaneously rotating it in a anticlockwise direction (to the left) will allow you to open the bottle.
  • On a table, position the open bottle upright.
  • With one hand, support the bottle vertically. Using your other hand, insert the measuring tool’s tip into the bottle’s centre opening. Firmly insert the tip into the opening.
  • With one hand, hold the bottle and measurement tool. Pull the plunger back with your other hand until it is level with the marking that corresponds to the dosage your doctor prescribed. To ensure that the medication flows into the measurement instrument, keep the bottle upright.
  • Take off the measuring cap from the bottle’s top. In one of the dosing cups that came with the drug, insert the measurement tool’s tip.
  • To release the drug into the dosage cup, depress the plunger.
  • Fill the dosing cup with 2 ounces (60 millilitres, 1/4 cup, or around 4 teaspoons) of tap water. Avoid combining the drug with any liquid, including fruit juice and soft drinks.
  • Put the dosage cup’s cap on. Cap should be turned clockwise (to the right) until a locking click can be heard.
  • Repeat steps 5 through 10 to make a second dose of sodium oxybate, potassium, calcium, and magnesium in a second dosing cup.
  • Wash the measurement tool in water.
  • Place the measurement equipment and the calcium, magnesium, potassium, and sodium oxybate bottle in a secure location that is out of the reach of children and animals. Put the cap on the bottle. Put the prepared medication dosing cup(s) in a secure location near your bed or in a secure location to give your child that is out of the reach of kids and dogs.
  • Put pressure on the cap and spin it anticlockwise when it’s time to take the first dose of calcium, magnesium, potassium, and sodium oxybate (to the left). Sit on your bed and down the entire bottle of liquid. Right away, lie down after replacing the cup’s cap and locking it in place by turning it clockwise (to the right).
  • If you are taking a second dose, follow step 14 again when you get up 2 1/2 to 4 hours later to take the second dose.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking calcium, magnesium, potassium, and sodium oxybate,

  • If you have an allergy to calcium, magnesium, potassium, or sodium oxybate, any other drugs, or any of the ingredients in calcium, magnesium, potassium, or sodium oxybate solution, let your doctor and pharmacist know right once. For a list of the ingredients, consult the Medication Guide or speak with your pharmacist.
  • Inform your doctor and pharmacist about any additional prescription and over-the-counter drugs, vitamins, herbal items, and nutritional supplements you are taking. Mention the following things: divalproex (Depakote). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects.
  • Inform your doctor if you have succinic semialdehyde dehydrogenase deficiency or have ever had it (an inherited condition in which certain substances build up in the body and cause retardation and developmental delays). Most likely, your physician will advise against taking calcium, magnesium, potassium, and sodium oxybate.
  • Inform your doctor if you snore, have trouble breathing, sleep apnea (a sleeping problem that causes breathing to stop for brief periods throughout sleep), seizures, depression or another mental illness, liver disease, or if you have ever thought about, plotted, or attempted to injure or kill yourself.
  • Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. Call your doctor if you get pregnant while taking calcium, magnesium, potassium, and sodium oxybate.
  • Inform your doctor or dentist that you are taking calcium, magnesium, potassium, and sodium oxybate if you are undergoing surgery, including dental surgery.
  • You should be aware that taking calcium, magnesium, potassium, and sodium oxybate will make you feel extremely sleepy for at least 6 hours. You may also feel sleepy during the day. For at least 6 hours after taking your prescription, avoid using machinery, piloting a vehicle, or engaging in any other risky activity. Until you are certain of how calcium, magnesium, potassium, and sodium oxybate impacts you, stay away from risky situations at all costs.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

If you forget to take your second calcium, magnesium, potassium, and sodium oxybate dose, skip it and resume your regular dosing plan the following evening. To make up for a missing dose, do not take a second one. The interval between dosages of calcium, magnesium, potassium, and sodium oxybate should always be at least 2 1/2 hours.

What side effects can this medication cause?

Side effects are possible with calcium, magnesium, potassium, and sodium oxybate. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Bedwetting
  • Headache
  • Dizziness
  • Your body trembles in a part that you can’t control.
  • Skin sensations such as tingling, burning, prickling, or creeping
  • Unable to move whether awake or while asleep
  • Nausea
  • Vomiting
  • Diarrhea
  • Dry mouth
  • Irritability
  • Weakness
  • Muscle spasms
  • Sweating

Certain adverse effects can be very harmful. Even though the following signs and symptoms are unusual, if you experience any of them or any of the warning signs detailed in the IMPORTANT WARNING section, call your doctor right once or seek emergency care:

  • Sleepwalking
  • Strange dreams
  • Agitation
  • Aggression
  • Anxiety
  • Depression
  • Uncertainty or issues with memory
  • Alterations in appetite or weight
  • Sense of guilt
  • Considering hurting or killing oneself
  • Sense like someone is out to get you
  • Hallucinations (seeing objects or hearing voices that do not exist)
  • Lack of awareness of reality
  • Issues with breathing, snoring, or sleep apnea
  • Daytime tiredness that is too severe

Further negative effects could be brought on by calcium, magnesium, potassium, and sodium oxybate. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this prescription tightly wrapped in the container it came in, out from the reach of children and animals. Keep it away from excessive heat and moisture at room temperature (not in the bathroom). If the drug has been prepared more than 24 hours ago, flush any leftover dose down the sink. Mark the bottle’s label with a marker and then throw it away along with the empty container. If you have concerns about how to properly dispose of your medication if it is no longer needed or is old, speak to your doctor or contact the central pharmacy.

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning. http://www.upandaway.org

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at http://goo.gl/c4Rm4p for additional information.

In case of emergency/overdose

Call 1-800-222-1222 to reach the poison control hotline in the event of an overdose. You can get information online at https://www.poisonhelp.org/help. Call emergency services at 911 right away if the sufferer has fallen, experienced a seizure, is having problems breathing, or cannot be roused.

Overdose symptoms could include:

  • Confusion
  • Difficulty coordinating
  • Agitation
  • Consciousness is lost
  • Coma
  • Breathing that is erratic, shallow, or rapid
  • Bladder control issues
  • Vomiting
  • Sweating
  • Headache
  • Blurred vision
  • Muscle jerks or twitches
  • Seizure
  • Slow heartbeat
  • Low body temperature
  • Weak muscles

What other information should I know?

If you have any inquiries regarding refilling your medication, contact the central pharmacy or ask your doctor.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Xywav®
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