PrescriptionGiant is a FREE prescription savings program that can save you up to 75% on your prescriptions with or without insurance!

Cafergot Rectal Suppository (Generic Ergotamine and Caffeine)

Actual product appearance may differ slightly.

Click the CARD below to print or take a screenshot on your mobile phone or tablet. There is no need to download another app!

If you would like to personalize your card enter your full name in the member name field below the card at this link and click the Update button.


Cafergot Rectal Suppository contains a combination of caffeine and ergotamine, used primarily to treat migraines. However, like any medication, it carries risks. Some potential risks of taking Cafergot Rectal Suppository include:

  • Cardiovascular Effects: Cafergot can constrict blood vessels, potentially leading to cardiovascular issues such as increased blood pressure or heart complications.
  • Drug Interactions: Cafergot can interact with other medications, particularly those metabolized by the liver, increasing the risk of adverse reactions or reduced effectiveness.
  • Ergotism: This is a rare but serious condition caused by ergotamine toxicity, characterized by symptoms like numbness, tingling, or coldness in extremities, muscle pain, confusion, and hallucinations.
  • Pregnancy Risks: Cafergot is not recommended during pregnancy due to potential risks to the fetus, including restricted blood flow.
  • Dependency: Regular use of Cafergot may lead to dependency or rebound headaches when discontinued, where headaches return more severe than before.
  • Side Effects: Common side effects include nausea, vomiting, dizziness, and weakness.

It’s crucial to use Cafergot only as directed by a healthcare professional and to be aware of these risks. Always discuss any concerns or potential side effects with your doctor.

Why is this medication prescribed?

Cafergot Rectal Suppository is typically prescribed to alleviate acute migraine attacks. It contains a combination of caffeine and ergotamine, which work together to constrict blood vessels in the brain, thus relieving migraine symptoms.

How should this medicine be used?

Here’s a general guideline on how Cafergot Rectal Suppository should be used:

  • Administration: The suppository is inserted into the rectum using the finger or a special applicator provided with the medication.
  • Dosage: The dosage is typically determined by the healthcare provider based on the severity of the migraine and the patient’s response to the medication. It’s essential to follow the prescribed dosage instructions carefully.
  • Timing: It’s best to use Cafergot as soon as possible after the onset of a migraine attack for maximum effectiveness.
  • Frequency: The medication is usually used at the onset of a migraine attack and can be repeated as directed by the healthcare provider. However, it’s important not to exceed the recommended dosage or frequency to avoid potential side effects or complications.
  • Precautions: Cafergot should not be used prophylactically (as a preventive measure) for migraines. It’s meant for acute treatment only. Also, avoid using Cafergot if you have certain medical conditions such as peripheral vascular disease or uncontrolled hypertension unless directed by a doctor.
  • Monitoring: If migraines persist or worsen despite using Cafergot, consult a healthcare provider for further evaluation and management.

Always use Cafergot as prescribed by a healthcare professional and discuss any questions or concerns about its use with them.

Other uses for this medicine

Some of these off-label uses might include:

  • Cluster Headaches: In some cases, Cafergot may be used to treat cluster headaches, another type of severe headache disorder.
  • Vascular Headaches: Certain types of vascular headaches may also be treated with Cafergot under the supervision of a healthcare professional.
  • Post-Dural Puncture Headache: Cafergot has been used off-label to manage post-dural puncture headaches, which can occur after certain medical procedures involving the spinal cord.

What special precautions should I follow?

Regarding special precautions for using Cafergot Rectal Suppository:

  • Medical History: Inform your healthcare provider about any medical conditions you have, especially if you have a history of cardiovascular disease, hypertension, liver or kidney problems, or peripheral vascular disease.
  • Medication Interactions: Cafergot can interact with other medications, including certain antibiotics, antifungal medications, antidepressants, and drugs used to treat HIV/AIDS. Inform your doctor about all the medications, supplements, and herbal products you are currently taking.
  • Pregnancy and Breastfeeding: Cafergot is generally not recommended during pregnancy or breastfeeding due to potential risks to the fetus or infant. Discuss the risks and benefits with your healthcare provider if you are pregnant or breastfeeding.
  • Smoking: Smoking may decrease the effectiveness of Cafergot. If you smoke, discuss this with your doctor.
  • Avoiding Overuse: To prevent medication overuse headaches or rebound headaches, use Cafergot strictly as directed by your healthcare provider. Avoid using it more frequently or at higher doses than recommended.
  • Allergies: Inform your doctor about any allergies you have, especially to ergotamine or similar medications.

Always follow your healthcare provider’s instructions and ask any questions you have about the proper use and precautions of Cafergot Rectal Suppository.

What special dietary instructions should I follow?

Regarding special dietary instructions, there are no specific dietary restrictions associated with Cafergot Rectal Suppository. However, maintaining a healthy diet and staying hydrated may help in managing migraine symptoms.

What should I do if I forget a dose?

If you forget a dose of Cafergot Rectal Suppository, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up. If you are unsure about what to do, consult your healthcare provider or pharmacist for advice.

What side effects can this medication cause?

Cafergot Rectal Suppository, like any medication, can cause side effects. Common side effects of Cafergot Rectal Suppository may include:

  • Nausea
  • Vomiting
  • Dizziness
  • Weakness
  • Tingling or numbness in the fingers or toes
  • Itching
  • Headache
  • Muscle pain
  • Leg cramps
  • Unpleasant taste in the mouth

These side effects are usually temporary and may improve as your body adjusts to the medication. However, if any of these side effects persist or worsen, contact your healthcare provider.

In addition to the common side effects, Cafergot Rectal Suppository may also cause more serious side effects in some individuals. These can include:

  • Signs of ergotism, such as severe stomach pain, rapid heartbeat, chest pain, confusion, hallucinations, seizures, or loss of consciousness.
  • Signs of circulation problems, such as coldness, numbness, or color changes in your fingers or toes.
  • Signs of a serious allergic reaction, including rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing.

If you experience any serious side effects or signs of an allergic reaction, seek immediate medical attention.

It’s essential to discuss any concerns about potential side effects with your healthcare provider before starting Cafergot Rectal Suppository. They can provide you with more information about the risks and benefits of this medication based on your individual medical history and condition.

What should I know about storage and disposal of this medication?

When it comes to storage and disposal of Cafergot Rectal Suppository:

  • Storage:
    • Store Cafergot Rectal Suppository at room temperature away from moisture, heat, and light.
    • Keep it out of reach of children and pets to prevent accidental ingestion.
  • Disposal:
    • Dispose of unused or expired Cafergot Rectal Suppository properly according to local regulations or guidelines.
    • Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Check with your pharmacist or local waste disposal company for proper disposal methods.

In case of emergency/overdose

  • Seek Medical Attention: If you suspect an overdose or experience severe symptoms such as chest pain, confusion, hallucinations, seizures, or loss of consciousness, seek immediate medical attention by calling your local emergency services or poison control center.
  • Symptomatic Treatment: Emergency medical professionals will provide supportive care to manage symptoms and may administer medications or treatments as needed to counteract the effects of the overdose.

What other information should I know?

  • Avoid Alcohol: Alcohol consumption while taking Cafergot may increase the risk of side effects such as dizziness or drowsiness.
  • Driving and Machinery: Cafergot may cause dizziness or drowsiness. Avoid driving or operating machinery until you know how this medication affects you.
  • Regular Follow-ups: Keep follow-up appointments with your healthcare provider to monitor your response to Cafergot Rectal Suppository and to make any necessary adjustments to your treatment plan.
  • Inform Healthcare Providers: Inform all healthcare providers involved in your care, including dentists and pharmacists, about all the medications you are taking, including over-the-counter medications, supplements, and herbal products.
  • Consistency: Try to take Cafergot Rectal Suppository at the same times each day to maintain a consistent level of medication in your body.

By following these guidelines and staying informed about the proper use, storage, disposal, and potential risks associated with Cafergot Rectal Suppository, you can use this medication safely and effectively under the guidance of your healthcare provider.

Copyright © 2023