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Cafatine Rectal Suppository (Generic Ergotamine and Caffeine)

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Cafatine Rectal Suppository contains a combination of ergotamine and caffeine and is primarily used for the treatment of migraine headaches. However, like any medication, it comes with certain risks and potential side effects. Some of the risks associated with taking Cafatine Rectal Suppository include:

  • Medication Overuse Headaches: Using Cafatine Rectal Suppository too frequently or for an extended period can lead to medication-overuse headaches. This can occur if the medication is used more than the recommended dosage or frequency.
  • Cardiovascular Effects: Ergotamine, one of the main ingredients in Cafatine, can constrict blood vessels. In some individuals, this can lead to cardiovascular side effects such as increased blood pressure, chest pain, or even rare but severe complications like heart attack or stroke.
  • Gastrointestinal Effects: Some people may experience nausea, vomiting, or abdominal discomfort after using Cafatine Rectal Suppository.
  • Central Nervous System Effects: Caffeine, another ingredient in Cafatine, can cause stimulation of the central nervous system, leading to side effects such as restlessness, anxiety, or insomnia.
  • Allergic Reactions: While rare, some individuals may experience allergic reactions to the components of Cafatine Rectal Suppository, which can manifest as rash, itching, swelling, or difficulty breathing.

It’s essential to use Cafatine Rectal Suppository only as directed by a healthcare provider and to be aware of these potential risks. If you experience any concerning symptoms or side effects while using Cafatine, it’s important to seek medical attention promptly. Additionally, always discuss any concerns or questions about the medication with your healthcare provider.

Why is this medication prescribed?

Cafatine Rectal Suppository is typically prescribed for the relief of moderate to severe pain, particularly when oral administration of medication is not feasible, such as in cases of nausea, vomiting, or difficulty swallowing. It contains a combination of caffeine and acetaminophen, which work together to provide pain relief.

How should this medicine be used?

Cafatine Rectal Suppository is typically used to relieve pain, reduce fever, and alleviate inflammation. Here’s a general guideline on how to use it:

  • Wash Hands: Before handling the suppository or administering it, wash your hands thoroughly with soap and water.
  • Prepare Suppository: Remove the suppository from its packaging. If it’s too soft, you can chill it in the refrigerator for a few minutes to make it easier to handle. Avoid excessive handling, as it may melt due to body heat.
  • Assume a Comfortable Position: Lie on your side with your lower leg slightly bent. Alternatively, you can kneel and bend forward, or lie on your stomach with your knees drawn up.
  • Insert Suppository: Gently insert the suppository into your rectum with your finger. Push it in as far as it comfortably goes. Try to relax your muscles during insertion to make it easier.
  • Remain in Position: Stay in the same position for a few minutes to prevent the suppository from coming out before it has a chance to dissolve.
  • Dispose of Packaging: Properly dispose of the packaging and wash your hands again.
  • Avoid Certain Actions: Avoid having a bowel movement for at least one hour after inserting the suppository to allow it to be fully absorbed.
  • Dosage: Follow the dosage instructions provided by your healthcare provider or as indicated on the packaging. Do not exceed the recommended dosage unless instructed by a healthcare professional.
  • Storage: Store the suppositories in a cool, dry place away from direct sunlight.

Remember, it’s essential to consult your healthcare provider before using any medication, including suppositories, to ensure it’s suitable for your condition and to get proper dosage instructions.

Other uses for this medicine

Cafatine Rectal Suppository, besides its primary use for pain relief, may also have other off-label uses. Some healthcare providers may prescribe it for conditions such as migraine headaches or menstrual cramps, but it’s essential to follow your doctor’s specific instructions regarding its use for any condition.

What special precautions should I follow?

Regarding special precautions:

  • Allergies: Inform your doctor if you are allergic to caffeine, acetaminophen, or any other medications before using Cafatine Rectal Suppository.
  • Medical Conditions: Inform your doctor about any medical conditions you have, such as liver disease, kidney disease, or any gastrointestinal problems, as these may affect the use of Cafatine Rectal Suppository.
  • Other Medications: Inform your doctor about any other medications, including over-the-counter drugs and supplements, you are taking, as they may interact with Cafatine Rectal Suppository.
  • Pregnancy and Breastfeeding: If you are pregnant or breastfeeding, consult your doctor before using Cafatine Rectal Suppository, as its safety during these periods may not be established.
  • Children and Elderly: Special caution should be taken when using Cafatine Rectal Suppository in children and elderly individuals. Dosage adjustments may be necessary, and it’s best to follow your doctor’s recommendations closely.
  • Driving and Operating Machinery: Cafatine Rectal Suppository may cause dizziness or drowsiness. Avoid driving or operating machinery until you know how this medication affects you.
  • Alcohol: Limit or avoid alcohol consumption while using Cafatine Rectal Suppository, as it may increase the risk of liver damage when combined with acetaminophen.

Always follow your healthcare provider’s instructions and read the medication label carefully. If you have any questions or concerns about using Cafatine Rectal Suppository, don’t hesitate to consult your doctor or pharmacist.

What special dietary instructions should I follow?

Regarding special dietary instructions, there are typically no specific dietary restrictions associated with Cafatine Rectal Suppository. However, it’s generally advisable to maintain a healthy, balanced diet while using any medication. If you have concerns about diet and medication interactions, consult your healthcare provider or pharmacist for personalized advice.

What should I do if I forget a dose?

If you forget a dose of Cafatine Rectal Suppository, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up. If you have any concerns or questions about missed doses, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Cafatine Rectal Suppository, like any medication, may cause side effects, although not everyone experiences them. Common side effects associated with Cafatine Rectal Suppository may include:

  • Gastrointestinal Disturbances: This can include nausea, vomiting, or stomach upset.
  • Rectal Discomfort: Mild irritation or discomfort in the rectal area where the suppository was inserted may occur.
  • Headache: Some individuals may experience headaches as a side effect of caffeine.
  • Dizziness or Drowsiness: These side effects may occur, particularly if you are sensitive to caffeine or acetaminophen.
  • Allergic Reactions: While rare, some people may experience allergic reactions such as rash, itching, swelling, or difficulty breathing. Seek immediate medical attention if you experience any signs of an allergic reaction.
  • Liver Damage: High doses or prolonged use of acetaminophen, one of the active ingredients in Cafatine Rectal Suppository, can lead to liver damage. It’s essential to adhere to the recommended dosage and duration of use.
  • Increased Heart Rate or Palpitations: Caffeine, another active ingredient, can sometimes cause palpitations or an increased heart rate in sensitive individuals.
  • Trouble Sleeping: Due to the stimulating effects of caffeine, some individuals may experience difficulty falling asleep or staying asleep.

If you experience any severe or persistent side effects while using Cafatine Rectal Suppository, contact your healthcare provider promptly. Additionally, if you have any concerns about side effects, it’s essential to discuss them with your doctor or pharmacist for further guidance.

What should I know about storage and disposal of this medication?

When it comes to storage and disposal of Cafergot:


  • Store Cafatine Rectal Suppository at room temperature, away from moisture and heat.
  • Keep it out of reach of children and pets.
  • Avoid storing it in the bathroom, as moisture can degrade the suppositories.


  • Dispose of unused or expired Cafatine Rectal Suppository properly according to local regulations or medication take-back programs.
  • Do not flush medications down the toilet unless instructed to do so.
  • Consult your pharmacist or healthcare provider for guidance on safe disposal methods.

In case of emergency/overdose

  • In case of an overdose or emergency, such as accidental ingestion of too much Cafatine Rectal Suppository, seek immediate medical attention or contact a poison control center.
  • Symptoms of overdose may include severe nausea, vomiting, abdominal pain, sweating, confusion, or liver damage.

What other information should I know?

  • Keep track of your medication usage, including dosage and frequency, to avoid accidental overdose.
  • Do not exceed the recommended dosage or duration of use without consulting your healthcare provider.
  • Inform any healthcare provider treating you that you are using Cafatine Rectal Suppository, as it may interact with other medications or treatments.
  • Avoid alcohol consumption while using Cafatine Rectal Suppository, as it may increase the risk of liver damage.
  • If you have any questions or concerns about Cafatine Rectal Suppository, consult your doctor or pharmacist for further information and guidance.

Following these guidelines can help ensure the safe and effective use of Cafatine Rectal Suppository. If you have any specific concerns or need further information, don’t hesitate to reach out to your healthcare provider or pharmacist.

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