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Cabozantinib (thyroid cancer)

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Why is this medication prescribed?

Treatment for a certain type of thyroid cancer that is progressing and has progressed to other body areas involves the drug cabotinib (Cometriq). Tyrosine kinase inhibitors, which include cabozantinib (Cometriq), are a class of drugs. It operates by obstructing the function of an aberrant protein that instructs cancer cells to proliferate. This aids in reducing or halting the growth of cancerous cells.

How should this medicine be used?

Cabozantinib (Cometriq) is available as a capsule to swallow. It is typically taken once daily, at least an hour before and two hours after eating, on an empty stomach. Take Cometriq (cabozantinib) at roughly the same time each day. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Take Cometriq (cabozantinib) exactly as prescribed. Never take it in larger or less amounts or more frequently than directed by your doctor.

With a full glass (8 ounces, 240 mL) of water, swallow the capsules whole. Never open them.

If you develop severe adverse effects, your doctor may lower your dose of cabozantinib (Cometriq) or temporarily or permanently stop your therapy. During your cabozantinib treatment, be sure to discuss your feelings with your doctor (Cometriq).

Your response to the drug and any side effects you encounter will determine how long you need to receive therapy. Even if you feel well, keep taking cabozantinib (Cometriq). Without first seeing your physician, do not discontinue taking cabozantinib (Cometriq).

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking cabozantinib (Cometriq),

  • If you have any allergies, including to cabozantinib (Cabometyx, Cometriq), other medicines, or any of the chemicals in cabozantinib capsules, notify your doctor right away. For a list of the ingredients, consult the Medication Guide or speak with your pharmacist.
  • Inform your doctor and pharmacist about any prescription and over-the-counter drugs, vitamins, and dietary supplements you are currently taking or intend to take. Incorporate any of the following: adefovir (Hepsera); antifungal medications include voriconazole (Vfend), itraconazole (Sporanox), and ketoconazole; dexamethasone, furosemide (Lasix), and clarithromycin (Biaxin, in Prevpac); as well as some HIV/AIDS medications like abacavir (Ziagen), atazanavir (Reyataz), cidofovir, indinavir (Crixivan), and lamivudine (Epivir, in Combivir); tenofovir (Viread), saquinavir (Invirase), and nelfinavir (Viracept); certain seizure medications like carbamazepine (Equetro, Tegretol, Teril), phenobarbital, and phenytoin (Dilantin, Phenytek); and ritonavir (Norvir, in Kaletra); nefazodone, probenecid (Probalan), rifabutin (Mycobutin), rifampin (Rifactin, Rifadin, in Rifamate, in Rifater), rifapentine (Priftin), telithromycin (Ketek), and warfarin are some examples of medications that are mentioned (Coumadin, Jantoven). Tell your doctor about all the drugs you are taking, including any not on this list, since many other drugs may also interact with cabozantinib (Cometriq). Your physician might need to adjust the dosage of your drugs or keep a closer eye on you for adverse effects.
  • Please let your doctor know if you are taking any herbal supplements, especially St. John’s wort.
  • If you have lately experienced any unusual or severe bleeding, such as blood in your cough or vomit or bloody or black tarry stools, let your doctor know. Moreover, let your doctor know if you have an open or healed wound, high blood pressure, liver illness, or any of these conditions in the past.
  • If you are pregnant or plan to become pregnant, let your doctor know. Before beginning cabozantinib therapy, you must get a pregnancy test. During and for four months following your final dose of cabozantinib, you shouldn’t get pregnant. See your physician about birth control options you can take while undergoing therapy. Call your doctor right away if you become pregnant while taking cabozantinib (Cometriq). The foetus could suffer from capazantinib.
  • If you are breastfeeding, let your doctor know. Breastfeeding is not advised during therapy and for four months following the last dose, according to your doctor.
  • You should be aware that both men and women who use this medicine may have decreased fertility. The dangers of taking cabozantinib should be discussed with your doctor (Cometriq).
  • Inform your physician or dentist that you are taking cabozantinib if you are having surgery (Cometriq). At least 21 days prior to your operation, your doctor will likely advise you to stop taking cabozantinib (Cometriq), and they will also advise you when you can resume taking the medicine.
  • You should be aware that the medication cabozantinib (Cometriq) may seriously harm your jaw. Before beginning to take cabozantinib and on a regular basis while undergoing therapy, you should get a dental exam. While using cabozantinib, be careful to properly brush your teeth and care for your mouth (Cometriq). Before getting any dental work done while taking this medication, see your doctor. Most likely, your physician would advise you to stop taking cabozantinib at least 21 days prior to dental surgery.
  • You should be aware that while taking cabozantinib, your blood pressure may rise (Cometriq). Throughout your therapy, your doctor will likely keep an eye on your blood pressure.

What special dietary instructions should I follow?

While using this medication, avoid consuming grapefruit, grapefruit juice, or any other foods, supplements, or grapefruit products.

What should I do if I forget a dose?

If you miss a dosage, take it as soon as you recall. Nevertheless, omit the missed dose and go on with your regular dosing schedule if there are less than 12 hours until your next scheduled dose. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

The drug cometriq (cabozantinib) may have negative effects. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Constipation
  • Hemorrhoids
  • Nausea
  • Vomiting
  • Heartburn
  • Alterations in food taste
  • Difficulties swallowing
  • Redness, swelling, blisters, or pain in the mouth or throat
  • Loss of appetite
  • Slim down
  • Weakness or fatigue
  • Aching joints
  • Muscular aches or cramps
  • Anxiety
  • Tingling, burning, or numbness in the legs, arms, feet, or hands
  • Arid skin
  • Skin that has thickened in patches
  • Hair fall
  • Greying or lightening of the hair
  • Alteration or hoarseness of voice

Some adverse effects may be severe. Get emergency medical care or call your doctor right away if you develop any of the following symptoms or any of those in the IMPORTANT WARNING section:

  • Blood or blood clots being coughed up
  • Vomiting bloody or coffee-ground-looking stuff
  • Thicker than normal menstrual bleedin
  • Black or crimson, tarry stool
  • Any unusually severe bruising or bleeding
  • Diarrhoea
  • Uncomfortable or sensitive abdominal area
  • Swelling or discomfort in the legs or arms
  • Breathing difficulty
  • Feeling dizzy or faint
  • Sweating
  • One side of your body may have numbness or weakness in the face, arm, or leg.
  • Dizziness
  • Abrupt balancing or coordination challenges
  • Uncomfortable or swollen gums
  • An abrupt, bad headache
  • Jaw ache
  • Toothache
  • Seizures
  • Sudden difficulty walking
  • Abrupt issues with vision
  • Confusion
  • Abruptly having trouble speaking or thinking coherently
  • Rash
  • The soles or palms of the hands developing redness, discomfort, swelling, or blisters
  • Mouth sores, nausea, or vomiting that makes it difficult to consume food or liquids

Further adverse effects of cabozantinib (Cometriq) are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Keep it away from excessive heat and moisture at room temperature (not in the bathroom).

Although many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medications website at for additional information.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  • Loss of memory
  • Confusion
  • Slim down

What other information should I know?

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to cabozantinib, your doctor will request specific lab tests (Cometriq).

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Cometriq®
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