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Cabazitaxel Injection

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White blood cells, a type of blood cell required to combat infection, may be significantly or even fatally decreased by cabasitaxel injection in your blood. Your chance of getting a serious infection rises as a result. If you are 65 years of age or older, have a fever and a low white blood cell count, have undergone radiation therapy, are unable to consume a balanced diet, or have ever done so, let your doctor know. Before and during therapy, your doctor will conduct laboratory tests to determine the quantity of white blood cells in your blood. Your doctor may lower your dose, stop or postpone therapy, or both if your white blood cell count is low. If your white blood cell count drops, your doctor may also recommend a medicine to assist prevent potentially fatal consequences. Call your doctor right away if you have any of the following symptoms: a sore throat, fever (higher than 100.4°F), chills, muscle pains, a cough, burning while urinating, or other infection-related symptoms.

When you get your first two infusions of cabazitaxel injection, especially, you may experience severe or life-threatening adverse reactions. At least 30 minutes before to receiving the cabazitaxel injection, your doctor will administer drugs to prevent an allergic response. You ought to receive your infusion in a setting that allows for prompt treatment in the event that you experience a negative reaction. Inform your physician if you have any allergies to polysorbate 80 or cabazitaxel injection (an ingredient found in some foods and medications). If you are unsure whether a food or medication to which you are allergic contains polysorbate 80, consult your doctor. The following symptoms may appear if you have an allergic response to cabazitaxel injection within a few minutes of the start of your infusion: rash, skin reddening, itching, lightheadedness, faintness, or tightening of the throat. If you encounter any of these signs, tell your doctor or nurse straight away.

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to the cabazitaxel injection, your doctor will prescribe a number of tests.

You should discuss the dangers of using cabazitaxel injection with your doctor.

Why is this medication prescribed?

Prostate cancer, or cancer of the male reproductive organ, is treated with cabazitaxel injection and prednisone after receiving previous treatments. The drug cabasitaxel injection belongs to the group of drugs known as microtubule inhibitors. It inhibits or stops the development of cancer cells.

How should this medicine be used?

A doctor or nurse will administer the liquid form of capaztaxel injection intravenously (into a vein) over the course of an hour in a medical setting. Typically, it is given once every three weeks.

Prednisone must be taken daily when you receive cabazitaxel injectable therapy. You must take prednisone precisely as directed by your physician. If you have skipped a dose or have not taken your prednisone as directed, let your doctor know right away.

If you have certain serious adverse effects, your doctor may decide to discontinue, postpone, or lower the dose of your medication. During your treatment, be careful to let your doctor know how you are feeling.

For a copy of the manufacturer’s information for the patient, ask your pharmacist or doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before receiving cabazitaxel injection,

  • If you have an allergy to cabazitaxel injection, any other drugs, polysorbate 80, or any of the other ingredients in cabazitaxel injection, inform your doctor and pharmacist right away. Get a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any vitamins, nutritional supplements, and prescription and over-the-counter drugs you are now taking or intend to take. Any of the following should be mentioned: Antiplatelet drugs, aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), clarithromycin (Biaxin), and antifungals such as ketoconazole (Nizoral), itraconazole (Sporanox), and voriconazole (Vfend), as well as anticoagulants (‘blood thinners’); various anti-HIV drugs, including atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); some seizure drugs, including carbamazepine (Carbatrol, Equetro, Tegretol), phenytoin (Dilantin), and phenobarbital; nefazodone; rifabutin (Mycobutin), rifapentine (Priftin); and rifampin (Rimactin, in Rifamate, in Rifater); telithromycin, as well as steroid medications (Ketek). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects. Tell your doctor about all of your current medications, even those not on this list, as many additional drugs may interact with cabazitaxel injection.
  • In particular, mention St. John’s wort to your doctor when you use any herbal remedies.
  • If you have liver illness now or previously, let your doctor know. Most likely, your doctor will advise against getting the cabazitaxel injection.
    Inform your physician if you have or have previously had anaemia or kidney problems (a lower than normal number of red blood cells).
  • You should be aware that men with prostate cancer typically take cabazitaxel injection. Cabazitaxel injection can harm a foetus if used by pregnant women. Receiving the cabazitaxel injection should not be done by women who are, or who may become, pregnant or who are nursing. Call your doctor if you obtain cabazitaxel injection while expecting. Using birth control will help you avoid getting pregnant while receiving cabazitaxel injectable therapy.
  • Inform the surgeon or dentist that you are receiving an injection of cabazitaxel if you are having surgery, including dental surgery.

What special dietary instructions should I follow?

If you plan to consume grapefruits or grapefruit juice while taking this medication, consult your doctor.

What side effects can this medication cause?

Side effects from capaztaxel injection are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Heartburn
  • Alterations in food taste
  • Reduced appetite
  • Slim down
  • Swelling in the mouth’s interior
  • Headache
  • Back or joint ache
  • Tingling, burning, or numbness in the legs, arms, feet, or hands
  • Hair fall

Some adverse effects may be severe. Call your doctor right away if you have any of the following symptoms or any of the ones detailed in the IMPORTANT CAUTION section:

  • Nausea
  • Diarrhea
  • Vomiting
  • Abdominal pain
  • Constipation
  • Edoema of the lower legs, lower arms, hands, feet, ankles, or face
  • Less urinations
  • Urine with blood in it
  • Stool with blood
  • Colour shifts in the stool
  • Dehydration symptoms include dry mouth, dark urine, decreased sweating, dry skin, and other symptoms
  • Unsteady heartbeat
  • Breathing difficulty
  • Light skin
  • Weakness or fatigue
  • Significant bruising or bleeding

Other side effects from capaztaxel injection are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Moreover, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  • Indications of infection include a sore throat, cough, fever, chills, muscle aches, and burning when urinating.
  • Significant bruising or bleeding
  • Light skin
  • Breathing difficulty
  • Extreme fatigue or weakened state
  • Nausea
  • Vomiting
  • Diarrhea

What other information should I know?

Ask your pharmacist any inquiries you may have regarding the injection of cabazitaxel.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Jevtana®
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