PrescriptionGiant is a FREE prescription savings program that can save you up to 75% on your prescriptions with or without insurance!

Butorphanol Injection

Actual product appearance may differ slightly.

Click the CARD below to print or take a screenshot on your mobile phone or tablet. There is no need to download another app!

If you would like to personalize your card enter your full name in the member name field below the card at this link and click the Update button.


Butorphanol injection is a medication primarily used for pain relief, particularly in surgical and obstetric settings. However, like all medications, it carries certain risks. Here are some of the potential risks associated with taking Butorphanol injection:

  • Respiratory Depression: Butorphanol can suppress breathing, especially when taken in high doses or in combination with other respiratory depressants like alcohol or benzodiazepines. This risk is particularly heightened in individuals with respiratory disorders.
  • Sedation and Dizziness: Butorphanol can cause drowsiness, dizziness, and impaired coordination. This can increase the risk of accidents, falls, and other injuries, particularly in activities that require mental alertness, such as driving.
  • Addiction and Dependence: Like other opioids, Butorphanol has the potential for addiction and dependence, especially with prolonged use or misuse. Individuals with a history of substance abuse or addiction may be at higher risk.
  • Withdrawal Symptoms: Abrupt discontinuation of Butorphanol after prolonged use can lead to withdrawal symptoms such as anxiety, agitation, sweating, muscle aches, and insomnia.
  • Hypotension: Butorphanol can cause low blood pressure, particularly when administered rapidly or in high doses. This can result in dizziness, fainting, and an increased risk of falls.
  • Nausea and Vomiting: These are common side effects of Butorphanol use, particularly when starting treatment or when doses are increased.
  • Allergic Reactions: Some individuals may experience allergic reactions to Butorphanol, which can range from mild skin reactions to severe anaphylaxis.
  • Interaction with Other Medications: Butorphanol can interact with other medications, such as certain antidepressants, antipsychotics, and sedatives, leading to potentially dangerous effects or reduced efficacy of either medication.

It’s crucial to use Butorphanol under the supervision of a healthcare professional who can monitor for these risks and adjust treatment as necessary. Patients should also be educated about the potential risks and advised to report any concerning symptoms to their healthcare provider promptly.

Why is this medication prescribed?

Butorphanol injection is prescribed primarily for the relief of moderate to severe pain, such as post-operative pain, labor pain, or pain associated with certain medical procedures. It belongs to a class of medications called opioid analgesics, which work by binding to opioid receptors in the brain and spinal cord to alleviate pain.

How should this medicine be used?

Here’s how Butorphanol injection should typically be used:

  • Dosage: The dosage of Butorphanol injection varies depending on the severity of pain, individual response to the medication, and other factors such as age and medical condition. It is usually administered by a healthcare professional in a clinical setting.
  • Administration: Butorphanol injection is typically given intravenously (IV) or intramuscularly (IM). The choice of administration route depends on factors such as the urgency of pain relief and the patient’s condition.
  • Frequency: The frequency of Butorphanol injections depends on the duration and intensity of pain. It is usually given as needed, with careful monitoring for effectiveness and potential side effects.
  • Caution: Butorphanol should be used with caution in certain populations, such as the elderly, those with respiratory disorders, and individuals with a history of substance abuse or addiction. Dosage adjustments may be necessary in these cases.
  • Avoiding Alcohol and Sedatives: Patients should avoid alcohol and other central nervous system depressants while taking Butorphanol, as these substances can increase the risk of respiratory depression and other adverse effects.
  • Gradual Discontinuation: If Butorphanol is used for an extended period, it should be tapered gradually to avoid withdrawal symptoms.
  • Storage: Butorphanol injection should be stored according to the manufacturer’s instructions, usually at room temperature away from light and moisture.

It’s essential to follow the prescribing healthcare provider’s instructions carefully and report any concerning symptoms or side effects promptly. Butorphanol should only be used under medical supervision and as prescribed to minimize the risk of adverse effects.

Other uses for this medicine

Butorphanol injection, primarily prescribed for pain relief, may also be used for other purposes under the guidance of a healthcare professional. These alternate uses might include:

  • Migraine Treatment: Butorphanol has been used off-label for the treatment of migraines, particularly when other medications have proven ineffective. It can help alleviate severe headache pain associated with migraines.
  • Anesthesia Adjunct: In some cases, Butorphanol may be used as an adjunct to anesthesia during surgical procedures to help manage pain and reduce the need for other anesthetic agents.
  • Labor Pain: Butorphanol may be used during labor to provide pain relief, particularly for women who prefer to avoid or minimize the use of epidural anesthesia.

What special precautions should I follow?

Special precautions should be observed when using Butorphanol injection. Here are some key considerations:

  • Respiratory Depression: Butorphanol can cause respiratory depression, especially in high doses or in individuals with preexisting respiratory conditions. Patients should be closely monitored for signs of respiratory depression, particularly during the initial stages of treatment.
  • Dependency and Withdrawal: Like other opioid medications, Butorphanol has the potential for dependence and withdrawal symptoms with prolonged use. Patients should be monitored for signs of addiction and withdrawal, and the medication should be tapered gradually when discontinuing treatment.
  • Sedation and Dizziness: Butorphanol can cause drowsiness, dizziness, and impaired cognitive function. Patients should avoid driving or operating machinery until they know how the medication affects them.
  • Hypotension: Butorphanol can cause low blood pressure, particularly when administered rapidly or in high doses. Patients should be monitored for signs of hypotension, and cautious dosing should be exercised, especially in individuals prone to hypotension.
  • Drug Interactions: Butorphanol can interact with other medications, including certain antidepressants, antipsychotics, and sedatives. Patients should inform their healthcare provider about all medications they are taking to avoid potential interactions.
  • Pregnancy and Breastfeeding: The safety of Butorphanol use during pregnancy and breastfeeding has not been established definitively. The potential risks and benefits should be carefully weighed, and the medication should only be used if the benefits outweigh the risks.
  • Allergic Reactions: Patients should be monitored for signs of allergic reactions, including rash, itching, swelling, or difficulty breathing. If an allergic reaction occurs, medical attention should be sought immediately.

Overall, Butorphanol injection should be used with caution and under the supervision of a healthcare professional. Patients should be informed about the potential risks and benefits of treatment and encouraged to report any concerning symptoms or side effects promptly.

What special dietary instructions should I follow?

Regarding dietary instructions, there are no specific dietary restrictions associated with Butorphanol injection. However, it’s always essential to maintain a balanced diet and stay hydrated, particularly when recovering from surgery or managing pain.

What should I do if I forget a dose?

If you forget a dose of Butorphanol injection, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you’re unsure about what to do, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Butorphanol injection, like any medication, can cause side effects. Common side effects may include:

  • Nausea and Vomiting: These are among the most common side effects of Butorphanol injection.
  • Dizziness and Drowsiness: Butorphanol can cause feelings of dizziness or drowsiness, which may impair your ability to perform certain tasks safely.
  • Headache: Some individuals may experience headaches as a side effect of Butorphanol.
  • Sweating: Excessive sweating can occur in some people using Butorphanol.
  • Flushing: Some individuals may experience flushing or reddening of the skin.
  • Constipation: Opioid medications like Butorphanol can slow down bowel movements, leading to constipation.
  • Weakness or Fatigue: Feeling weak or tired is another possible side effect.
  • Dry Mouth: Butorphanol may cause a dry sensation in the mouth.
  • Itching: Some individuals may experience itching or skin irritation.
  • Respiratory Depression: In rare cases, Butorphanol can cause respiratory depression, particularly in high doses or in individuals with respiratory conditions.
  • Hypotension: Butorphanol can cause low blood pressure, leading to symptoms such as dizziness or fainting.
  • Allergic Reactions: Although rare, allergic reactions to Butorphanol can occur, leading to symptoms such as rash, itching, swelling, or difficulty breathing. If you experience any signs of an allergic reaction, seek medical attention immediately.

It’s important to note that this is not a complete list of all possible side effects. Some individuals may experience other side effects not listed here. If you experience any concerning or persistent side effects while taking Butorphanol injection, contact your healthcare provider for further guidance.

What should I know about storage and disposal of this medication?

Here’s what you should know about the storage and disposal of Butorphanol injection:


  • Store Butorphanol injection at room temperature, away from light and moisture.
  • Keep it out of reach of children and pets.
  • Do not freeze Butorphanol injection.
  • Follow any specific storage instructions provided by your healthcare provider or pharmacist.


  • Dispose of Butorphanol injection properly according to local regulations or guidelines.
  • Do not flush Butorphanol injection down the toilet or pour it down the drain unless instructed to do so.
  • Consult your pharmacist or healthcare provider for information on safe disposal methods, such as medication take-back programs or local medication disposal services.

In case of emergency/overdose

  • If you suspect an overdose or experience severe symptoms such as difficulty breathing, extreme drowsiness, unconsciousness, or seizures, seek emergency medical attention immediately.
  • Contact your local poison control center or emergency services for further assistance.
  • Be prepared to provide information about the amount of Butorphanol injection taken, the time it was taken, and any symptoms experienced.

What other information should I know?

  • Keep all appointments with your healthcare provider while using Butorphanol injection. Your doctor may need to monitor your response to the medication and adjust your dosage accordingly.
  • Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with Butorphanol injection.
  • Avoid consuming alcohol or using other central nervous system depressants while taking Butorphanol injection, as this can increase the risk of side effects such as respiratory depression and drowsiness.
  • Do not share Butorphanol injection with others, even if they have similar symptoms or conditions.
  • If you have any questions or concerns about Butorphanol injection, talk to your healthcare provider or pharmacist for more information and guidance.
Copyright © 2023