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Butorphanol Injection

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WARNING

Injections of butorphanol have the potential to become addictive, especially over time. Follow the injection’s instructions precisely. Use it only as prescribed by your doctor, and don’t take more of it, use it more frequently, or use it in a different way. When using butorphanol injection, be sure to discuss your pain management options, treatment duration, and goals with your doctor. Inform your doctor if you or any members of your family regularly use excessive amounts of alcohol, use illicit drugs, abuse prescription drugs, or have ever experienced depression or another mental disease. If you currently have or have ever had any of these conditions, there is a higher chance that you may overuse butorphanol. If you suspect that you may have an opioid addiction, speak with your doctor right away and ask for advice, or call the U.S. Substance Abuse and Mental Health Services Administration (SAMHSA) National Helpline at 1-800-662-HELP.

Breathing issues from butorphanol injection can be severe or even fatal, especially in the first 24 to 72 hours of treatment and whenever the dose is raised. Throughout your therapy, your doctor will keep a close eye on you. If you have asthma or slow breathing, let your doctor know. Most likely, your doctor will advise against using butorphanol injection. Inform your physician if you have ever experienced lung disease, such as chronic obstructive pulmonary disease (COPD), a group of illnesses that damage the lungs and airways. Also mention any head injuries you may have had, as well as any conditions that cause your brain to become more pressurised. The likelihood that you will experience breathing issues may be increased if you are an older adult, weak, or undernourished as a result of a sickness. Get emergency medical care if you encounter any of the following symptoms, or call your doctor right away: sluggish breathing, protracted breath gaps, or shortness of breath.

The risk of serious or life-threatening respiratory issues may rise when using specific additional drugs along with butorphanol injection. Inform your doctor and pharmacist if you are currently taking or intend to start taking any of the following medications: benzodiazepines such as estazolam, flurazepam, lorazepam (Ativan), oxazepam, temazepam (Restoril), and triazolam (Halcion); muscle relaxants; other narcotic pain medications; sedatives; sleeping pills; or tranquillizers; medications for anxiety, mental illness, or nausea Your prescription doses may need to be adjusted, and your doctor will closely monitor you.

While receiving butorphanol injectable treatment, using illicit substances, drinking alcohol, or taking prescription or over-the-counter medications that include alcohol increases your risk of developing these severe, perhaps fatal adverse effects. Don’t consume alcohol or use illicit substances while receiving treatment.

If you are pregnant or want to become pregnant, let your doctor know. Regular butorphanol injectable use during pregnancy increases the risk that your unborn child will have potentially fatal withdrawal symptoms. If your infant exhibits any of the following symptoms, contact your doctor straight away: irritability, hyperactivity, disturbed sleep, high-pitched crying, excessive shaking of a body part, vomiting, diarrhoea, or failure to gain weight.

The manufacturer’s patient information sheet (Medication Guide) will be provided to you by your doctor or pharmacist when you start butorphanol injection therapy and each time you fill a prescription. If you have any questions, carefully read the material and contact your doctor or pharmacist. The Medication Guide is also available on the manufacturer’s website or the Food and Drug Administration (FDA) website.

Why is this medication prescribed?

Injections of butorphanol are used to treat moderate to severe pain. Additionally, butorphanol injections are used to lessen consciousness and minimise discomfort prior to or during surgery as well as during birth. Butorphanol belongs to a group of drugs known as opioid agonist-antagonists. It functions by altering how the body perceives pain.

How should this medicine be used?

To be injected into a muscle or vein, butorphanol injection is available as a liquid. When butorphanol injection is used to treat pain, it is typically administered as needed once every 3 to 4 hours. Butorphanol injection may be administered 60 to 90 minutes prior to surgery and then as needed throughout the procedure to reduce pain. Butorphanol injections can be given once every four hours to alleviate labour pain, but they shouldn’t be given any earlier than four hours before the planned delivery time.

Butorphanol injection can be administered in a hospital setting, or the drug can be sent to you for use at home. It is crucial that you take the medication exactly as prescribed if you are instructed to administer butorphanol injection at home. Ask your physician, pharmacist, or nurse for clarification if you have any questions about how to proceed after receiving treatment.

If your doctor has instructed you to administer butorphanol injection at home, do not stop doing so without first consulting your physician. You could have withdrawal symptoms like anxiety, agitation, trembling, shakes, diarrhoea, chills, sweats, trouble falling asleep or staying asleep, confusion, loss of coordination, or hallucinations if you suddenly stop using butorphanol injection (seeing things or hearing voices that do not exist). Your dose will likely be gradually reduced by your doctor.

Other uses for this medicine

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before using butorphanol injection,

  • If you have an allergy to butorphanol, any other drugs, or any of the ingredients in butorphanol injection, tell your doctor and pharmacist right away. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any vitamins, nutritional supplements, herbal items, and prescription and over-the-counter medicines you are now taking or intend to take. Any of the following should be mentioned: Barbiturates as butabarbital (Butisol), pentobarbital (Nembutal), phenobarbital, or secobarbital (Seconal), antidepressants, antihistamines, cyclobenzaprine (Amrix), dextromethorphan (found in many cough medicines; in Nuedexta), erythromycin (E.E.S., Eryc, Erythrocin, etc); pharmaceuticals to treat seizures; lithium (Lithobid); drugs to treat migraines like almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), rizatriptan (Maxalt), sumatriptan (Alsuma, Imitrex, in Treximet), and zolmitriptan (Zomig); mirtazapine (Remeron); and 5HT3 seroton (Anzemet), selective serotonin-reuptake inhibitors like citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Prozac, Pexeva), and sertraline (Zoloft); granisetron (Kytril), ondansetron (Zofran, Zuplenz), tricylic antidepressants, also known as “mood lifts,” include amitriptyline and clomipramine. Serotonin and norepinephrine reuptake inhibitors include duloxetine (Cymbalta), desvenlafaxine (Khedezla, Pristiq), milnacipran (Savella), and venlafaxine (Effexor) (Anafranil), nortriptyline (Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); theophylline (Theochron, Uniphyl, and others); and trazodone are examples of medications (Oleptro). Also let your physician or pharmacist know if you are receiving any of the following monoamine oxidase (MAO) inhibitors, or if you have stopped taking them within the previous two weeks: methylene blue, isocarboxazid (Marplan), linezolid (Zyvox), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate). Telling your doctor about all of the medications you are taking, even those not on this list, is important because many other drugs may also interact with butorphanol. The dosage of your drugs may need to be adjusted, and your health may need to be closely watched for any negative effects.
  • If you use any herbal supplements, especially St. John’s wort or tryptophan, let your doctor know.
  • Inform your physician if you experience or have ever experienced urinary incontinence, heart attacks, high blood pressure, or liver, renal, or cardiac disease.
  • Inform your doctor if you are nursing a child. Some women who take butorphanol injection may have higher levels of the drug in their breast milk, which can have detrimental or fatal effects on the infants who are nursed. Additionally, if your baby is sleeping more than normal, has problems breathing or breastfeeding, or starts to limp, you should phone the doctor or seek emergency assistance.
  • You should be aware that this medicine may lower both male and female fertility. The dangers of using butorphanol should be discussed with your doctor.
  • Inform the surgeon or dentist that you are using butorphanol injection if you are having surgery, including dental surgery.
  • The injection of butorphanol may cause you to feel sleepy and lightheaded. For at least one hour after receiving a dose, avoid operating machinery or driving a car. After one hour, refrain from driving until you are certain you are not feeling lightheaded, sleepy, or less alert than usual.

What special dietary instructions should I follow?

Keep eating normally unless your doctor instructs you otherwise.

What should I do if I forget a dose?

When necessary, butorphanol injection is typically employed. Use the missed dose as soon as you remember it if your doctor has instructed you to regularly administer butorphanol injection. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

Side effects from butorphanol injection are possible. If any of these symptoms are severe or do not go away, let your doctor know right once:

  • Excessive fatigue
  • Having trouble falling or staying asleep
  • Strange dreams
  • Headache
  • Constipation
  • Abdominal pain
  • Feel heated
  • Flushing
  • Numbness, tingling, burning, or pain in the hands or feet
  • Uncontrollable trembling in a bodily portion
  • Nervousness
  • Hostility
  • Extremely content
  • Floating sensation
  • Gloomy attitude
  • Distorted vision
  • An earache that ringers
  • An earache
  • Unappealing flavour
  • Mouth ache
  • Having trouble urinating

Some adverse effects can be very harmful. Call your doctor right away or seek emergency medical help if you encounter any of these signs or any of the ones detailed in the IMPORTANT WARNINGS section:

  • Hallucinations (seeing or hearing objects or voices that aren’t there), agitation, sweating excessively, confusion, rapid heartbeat, shivering, extremely rigid or twitching muscles, loss of coordination, nausea, vomiting, or diarrhoea
  • Nnausea, vomiting, appetite loss, exhaustion, or lightheadedness
  • Failure to achieve or maintain erection
  • Abnormal menstruation
  • Reduced sexual arousal
  • Having trouble breathing
  • Alterations in heartbeat
  • Fainting
  • Rash
  • Hives

Other negative consequences from butorphanol injection are possible. If you experience any strange issues while taking this drug, call your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

If you use butorphanol injection at home, keep the medication tightly closed in the original container and away from children. Store it away from light, excessive heat, and moisture at room temperature (not in the bathroom). Medication that has expired or is no longer required should be thrown away. Consult your pharmacist for advice on how to properly dispose of your medications.

To prevent unauthorised or intentional use, store butorphanol injection in a secure location. To find out if any medication is missing, keep track of how much is still in the bottle.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning. http://www.upandaway.org

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at https://www.poisonhelp.org/help. Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

If you use butorphanol injection, your doctor might advise you to keep naloxone, a life-saving drug, on hand at all times (e.g., home, office). Naloxone is used to undo an overdose’s potentially fatal consequences. To treat harmful symptoms brought on by excessive levels of opiates in the blood, it functions by inhibiting the effects of opiates. If you overdose on opiates, you probably won’t be able to heal yourself. Make sure your family, carers, or those who spend time with you are aware of the signs of an overdose, how to administer naloxone, and what to do until emergency assistance arrives. You and your family members will be shown how to use the medication by your doctor or pharmacist. For the directions, speak to your pharmacist or go to the manufacturer’s website. If someone notices that you are exhibiting overdose symptoms, they should provide your initial dose of naloxone, dial 911 right away, and stay by your side while keeping a careful eye on you until emergency medical assistance comes. After receiving naloxone, your symptoms can come back a short while later. The person should administer you another dose of naloxone if your symptoms come back. If symptoms reappear before receiving medical attention, more doses may be given every 2 to 3 minutes.

Overdose signs could include the following:

  • Shallow or sluggish breathing
  • Coma (loss of consciousness for a period of time)
  • Death

What other information should I know?

Keep all of your appointments with your physician and the lab. To monitor your body’s reaction to butorphanol, your doctor will request specific lab tests.

Inform your doctor and the lab staff that you are taking butorphanol before undergoing any laboratory tests (particularly those that use methylene blue).

Keep your meds to yourself. Call your doctor if you experience pain after the butorphanol injection is finished.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Stadol®
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