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Busulphan (Generic Busulfan)

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Your bone marrow’s ability to produce blood cells may suffer significantly if you take busulfan. All of the medications you are taking should be disclosed to your doctor and pharmacist. The negative effects of the medications could be worse if you combine busulfan with other drugs that could lower your blood count. Call your doctor right away if you have any of the following symptoms: Unusual bleeding or bruises; fever, sore throat, persistent cough, and congestion, among other infection-related symptoms.

Keep all of your appointments with your physician and the lab. Before, during, and after your treatment, your doctor will conduct laboratory tests to monitor your body’s response to the medicine busulfan and determine whether it has an impact on your blood cells. If your blood count has fallen too low, your doctor may need to adjust your dose or advise you to temporarily stop taking busulfan so that it can rise again. Ask your doctor if you have any questions about how much busulfan you should be taking and closely adhere to his or her instructions.

Busulfan may make you more likely to get other malignancies. You should discuss the dangers of taking busulfan with your doctor.

Why is this medication prescribed?

A specific variety of chronic myelogenous leukaemia is treated with busulfan (CML; a type of cancer of the white blood cells). Alkylating agents are a class of drugs that includes busulfan. It functions by reducing or halting the development of cancer cells within your body.

How should this medicine be used?

Busulfan is available as a pill to be swallowed once daily. The sort of drugs you are taking, how well your body reacts to them, and the type of cancer you have will all affect how long your treatment will last. Take busulfan every day at about the same time. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Follow the busulfan directions exactly. Never take it in larger or less amounts or more frequently than directed by your doctor.

Depending on how you respond to the medication and any adverse effects you experience, your doctor may change the dose of busulfan you are taking. Discuss your feelings regarding your treatment with your doctor. Without first consulting your doctor, do not discontinue taking busulfan.

Other uses for this medicine

In order to prepare for a bone marrow transplant, cancer cells and bone marrow are also destroyed with busulfan tablets in combination with other medications.

Ask your doctor or pharmacist for more details if you believe this drug should be used for something else.

What special precautions should I follow?

Before taking busulfan,

  • If you have an allergy to busulfan, any other medications, or any of the ingredients in busulfan tablets, let your doctor and pharmacist know right away. Request a list of the components from your pharmacist.
  • Inform your doctor and pharmacist about any vitamins, nutritional supplements, herbal items, and prescription and over-the-counter medicines you are now taking or intend to take. Any of the following should be mentioned: medications for mental illness and nausea, phenytoin (Dilantin), meperidine, acetaminophen (Tylenol), cyclosporine (Sandimmune, Gengraf, Neoral), lomustine (CeeNU), melphalan (Alkeran), procarbazine (Mutalane), temozolomide (Temodar), and/or ifosfamide (Demerol). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for side effects. Tell your doctor about all of the medications you are taking, even any not on this list, as many other drugs may also interact with busulfan.
  • Inform your doctor if you have ever experienced seizures or a head injury, received radiation therapy or other chemotherapeutic treatments in the past. Tell your doctor if you have previously taken busulfan but your cancer did not improve after taking it.
  • You should be aware that busulfan may affect a woman’s regular menstrual cycle and that it may prevent sperm from developing in a man. You shouldn’t, however, presumptuously believe that you or another person cannot become pregnant. Pregnant or nursing women should inform their doctors before starting this medication. While undergoing chemotherapy or for a while after treatments, you shouldn’t intend to get pregnant. (Ask your doctor for more information.) To prevent conception, use a proven birth control method. While taking busulfan, call your doctor right away if you become pregnant. The foetus could suffer from busulfan.

What should I do if I forget a dose?

If you miss a dosage, take it as soon as you recall. If the next dose is soon due, skip the missed one and carry on with your regular dosing plan. To make up for a missing dose, do not take a second one.

What side effects can this medication cause?

Busulfan could have unfavourable effects. Inform your doctor right once if any of these symptoms are severe or persistent:

  • Nausea
  • Diarrhea
  • Appetite loss or weight loss
  • Constipation
  • In the mouth and throat sores
  • Mouth ache
  • Headache
  • Having trouble falling or staying asleep
  • Feeling unusually worried or anxious
  • Dizziness
  • Face, arm, hand, foot, ankle, or lower leg swelling
  • Chest pain
  • Back, joint, or muscle pain
  • Skin rash
  • Dry skin and itching
  • Skin coloration
  • Hair fall

Some adverse effects can be very harmful. Call your doctor right away if you have any of these signs or any of those in the IMPORTANT WARNING section:

  • Tarry, black stools
  • Red faeces
  • Unusual weakness or fatigue
  • Having trouble breathing
  • Alterations to vision
  • Vomiting
  • Abdominal pain
  • Seizures

Busulfan may prevent girls from reaching puberty and lead to ovarian failure. Consult your doctor on the possibility of infertility brought on by busulfan. You should discuss the dangers of using this drug with your doctor.

Other negative effects of busulfan are possible. If you experience any strange issues while taking this medicine, contact your doctor right away.

You or your doctor can submit a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting programme online or by phone if you have a serious side event (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication tightly closed in the original container and out of the reach of children. Store it away from excessive heat and moisture at room temperature (not in the bathroom).

Unused prescriptions must be disposed of carefully to prevent pets, kids, and other people from ingesting them. You should not, however, dispose of this medication in the toilet. Instead, utilising a medicine take-back programme is the easiest approach to get rid of your medication. To find out about take-back programmes in your area, speak with your pharmacist or the garbage/recycling department in your city. If you do not have access to a take-back programme, see the FDA’s Safe Disposal of Medicines website at for additional information.

As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Always lock safety caps and promptly stash medication up and away from young children where it is out of their sight and reach to prevent poisoning.

In case of emergency/overdose

Call the poison control hotline at 1-800-222-1222 in the event of an overdose. Additionally, information can be found online at Call 911 right once if the person has collapsed, experienced a seizure, is having difficulty breathing, or cannot be roused.

Overdose signs could include the following:

  • Tarry, black stools
  • Red faeces
  • Abnormal bleeding or bruising
  • Unusual weakness or fatigue
  • Fever, cough, sore throat, or other infection-related symptoms
  • Nausea
  • Vomiting
  • Diarrhea
  • In the mouth and throat sores

What other information should I know?

No one else should take your medication. Any queries you may have regarding medication refills should be directed to your pharmacist.

You should keep a written record of every medication you take, including any over-the-counter (OTC) items, prescription drugs, and dietary supplements like vitamins and minerals. This list should be brought with you whenever you see a doctor or are admitted to the hospital. You should always have this information with you in case of emergencies.

Brand names

  • Myleran®
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