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Burosumab-twza Injection

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Why is this medication prescribed?

Burosumab-twza Injection is prescribed to treat X-linked hypophosphatemia (XLH) in adult and pediatric patients 6 months of age and older. XLH is a rare, inherited disorder characterized by low levels of phosphate in the blood, which can lead to bone abnormalities, such as rickets in children and osteomalacia (softening of the bones) in adults. Burosumab-twza works by blocking the action of a protein that regulates phosphate levels in the body, thereby increasing phosphate levels and improving bone mineralization.

How should this medicine be used?

Burosumab-twza Injection is typically administered subcutaneously (under the skin) by a healthcare professional. Here are the general steps for using Burosumab-twza:

  • Preparation: Wash your hands thoroughly with soap and water. Gather all the necessary supplies, including the medication vial, syringe, alcohol swabs, and a sharps disposal container.
  • Inspect the medication: Check the expiration date and visually inspect the medication vial for any signs of damage or particles. Do not use the medication if it appears cloudy or contains particles.
  • Clean the injection site: Choose an injection site, such as the thigh or abdomen, and clean the skin with an alcohol swab. Allow the skin to dry completely before proceeding.
  • Prepare the medication: If the medication needs to be refrigerated, remove it from the refrigerator and let it sit at room temperature for a short period of time as directed by your healthcare provider. Draw up the prescribed dose of Burosumab-twza into the syringe.
  • Administer the injection: Pinch a fold of skin at the cleaned injection site. Insert the needle into the skin at a 45 to 90-degree angle, depending on the length of the needle and your healthcare provider’s instructions. Slowly inject the medication, then withdraw the needle and release the skin fold.
  • Dispose of used supplies: Safely dispose of the used syringe and needle in a sharps disposal container. Do not recap the needle. Wash your hands again thoroughly after handling the injection supplies.
  • Follow-up: Keep track of your injection schedule and attend all follow-up appointments with your healthcare provider. They may adjust your dosage or frequency of injections based on your response to the medication and any changes in your condition.

Always follow the specific instructions provided by your healthcare provider for using Burosumab-twza. If you have any questions or concerns about the administration process, don’t hesitate to ask your healthcare provider or pharmacist for clarification.

Other uses for this medicine

Burosumab-twza Injection is primarily used for the treatment of X-linked hypophosphatemia (XLH), a rare genetic disorder characterized by low levels of phosphate in the blood. While its primary use is for XLH, there may be ongoing research or off-label uses being explored. However, it’s essential to use the medication only as prescribed by your healthcare provider.

What special precautions should I follow?

Regarding special precautions for Burosumab-twza Injection, here are some important considerations:

  • Allergies: Inform your healthcare provider if you have any allergies, particularly to medications or any ingredients in Burosumab-twza Injection. This medication contains ingredients that may cause allergic reactions in some individuals.
  • Medical history: Provide your healthcare provider with your complete medical history, including any other medical conditions you have, especially kidney or liver problems, as well as any medications you are currently taking, including over-the-counter drugs, supplements, or herbal remedies.
  • Pregnancy and breastfeeding: If you are pregnant or planning to become pregnant, or if you are breastfeeding, discuss the risks and benefits of using Burosumab-twza Injection with your healthcare provider. It’s essential to weigh the potential risks to the fetus or infant against the potential benefits of treatment.
  • Monitoring: Your healthcare provider will likely monitor your phosphate levels, bone health, and kidney function regularly while you are receiving Burosumab-twza Injection. This monitoring helps ensure the medication is working effectively and that any potential side effects or complications are detected early.
  • Injection site reactions: Like with any injectable medication, Burosumab-twza Injection may cause injection site reactions, such as pain, redness, or swelling at the injection site. If you experience any persistent or severe reactions, notify your healthcare provider.
  • Potential side effects: Be aware of potential side effects associated with Burosumab-twza Injection, such as headache, nausea, joint pain, or changes in kidney function. Contact your healthcare provider if you experience any concerning symptoms.

Always follow your healthcare provider’s instructions and advice regarding the use of Burosumab-twza Injection, including any precautions or special considerations specific to your individual situation. If you have any questions or concerns, don’t hesitate to discuss them with your healthcare provider.

What special dietary instructions should I follow?

Burosumab-twza Injection may affect phosphate levels in the body, so it’s essential to maintain a balanced diet. Your healthcare provider may recommend dietary adjustments, including foods rich in phosphate, such as dairy products, meat, fish, nuts, and whole grains. Follow any dietary recommendations provided by your healthcare provider.

What should I do if I forget a dose?

If you miss a dose of Burosumab-twza Injection, take it as soon as you remember. However, if it’s almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.

If you’re unsure about what to do if you miss a dose or if you have any concerns about your treatment regimen, contact your healthcare provider for guidance.

What side effects can this medication cause?

Burosumab-twza Injection, like any medication, can cause side effects, although not everyone may experience them. Common side effects may include:

  • Injection site reactions: Pain, redness, bruising, or swelling at the injection site are common.
  • Headache: Some individuals may experience headaches after receiving Burosumab-twza Injection.
  • Nausea: Nausea or stomach discomfort may occur in some patients.
  • Muscle or joint pain: Pain or discomfort in muscles or joints may be reported.
  • Hypersensitivity reactions: Rarely, severe allergic reactions may occur, characterized by symptoms such as rash, itching, swelling of the face, tongue, or throat, difficulty breathing, or severe dizziness. Seek immediate medical attention if you experience any signs of a severe allergic reaction.
  • Kidney problems: In some cases, Burosumab-twza Injection may affect kidney function. Your healthcare provider may monitor your kidney function regularly while you are receiving treatment.
  • Increased risk of hyperphosphatemia: Burosumab-twza Injection works by increasing phosphate levels in the blood, which may lead to hyperphosphatemia (elevated phosphate levels). Your healthcare provider will monitor your phosphate levels to avoid complications associated with high phosphate levels, such as soft tissue calcification.

It’s essential to report any side effects or adverse reactions you experience while receiving Burosumab-twza Injection to your healthcare provider. They can provide guidance on managing side effects and adjust your treatment plan if necessary.

Remember, this list of side effects is not exhaustive, and other side effects may occur. If you have any concerns about potential side effects or reactions to Burosumab-twza Injection, discuss them with your healthcare provider.

What should I know about storage and disposal of this medication?

Storage and Disposal:

  • Storage: Store Burosumab-twza Injection in the refrigerator at a temperature between 2°C to 8°C (36°F to 46°F). Do not freeze. Keep the medication in its original carton to protect it from light. If necessary, Burosumab-twza can be kept at room temperature (up to 30°C or 86°F) for a single period of up to 30 days. Once removed from the refrigerator, do not put it back in the refrigerator.
  • Disposal: Dispose of used needles and syringes in a puncture-resistant sharps disposal container. Do not throw them in the household trash. Follow your local regulations for the proper disposal of sharps containers. If you have any unused or expired Burosumab-twza Injection, consult your healthcare provider or pharmacist for proper disposal instructions.

In case of emergency/overdose

In case of an emergency or suspected overdose of Burosumab-twza Injection, seek immediate medical attention or contact your local poison control center at 1-800-222-1222 (United States). Overdose symptoms may include an excessive increase in phosphate levels, which could lead to symptoms such as nausea, vomiting, diarrhea, muscle weakness, or seizures.

What other information should I know?

  • Follow-up appointments: Attend all scheduled follow-up appointments with your healthcare provider to monitor your response to Burosumab-twza Injection and adjust your treatment plan as needed.
  • Laboratory tests: Your healthcare provider may perform regular blood tests to monitor your phosphate levels, kidney function, and overall health while you are receiving Burosumab-twza Injection.
  • Travel considerations: If you need to travel with Burosumab-twza Injection, take appropriate measures to ensure the medication remains within the recommended temperature range. Consider using a travel cooler with ice packs for refrigerated medications during transit.
  • Keep out of reach of children: Store Burosumab-twza Injection and all medications out of the reach of children and pets.
  • Additional information: If you have any questions or concerns about Burosumab-twza Injection, including its administration, dosage, or potential side effects, don’t hesitate to discuss them with your healthcare provider or pharmacist.

As always, follow your healthcare provider’s instructions and advice regarding the use of Burosumab-twza Injection and any additional precautions or recommendations specific to your individual situation.

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